Doxorubicin (CID 443939) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(675)
 
 
Top Targets:
Bcl-2 like(10)
 
 
NR LBD TR(6)
 
 
NR LBD ROR li..(6)
 
 
LRR RI(4)
 
 
Peptidase S9(4)
 
 
BioAssay Types:
Literature(213)
 
 
Screening(141)
 
 
Confirmatory(136)
 
 
BioActivity Types:
IC50(142)
 
 
Potency(84)
 
 
EC50(15)
 
 
AC50(7)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 480    Data Row: 675   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234257]
IC50 0.006Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay [AID673199, Type: Literature]
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2
[SID104234257]
IC50 0.01Antiproliferative activity against human K562 cells after 48 hrs [AID494501, Type: Literature]
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3
[SID104234257]
IC50 0.01Cell growth inhibition of human K562 cells after 48 hrs [AID494520, Type: Literature]
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4
[SID104234257]
IC50 0.01Antiproliferative activity against human K562 cells after 48 hrs [AID303684, Type: Literature]
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5
[SID104234257]
IC50 0.01Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID333312, Type: Literature]
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6
[SID104234257]
IC50 0.012Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay [AID333313, Type: Literature]
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7
[SID104234257]
IC50 0.017In vitro inhibitory activity against cancerous P388 cell line [AID150546, Type: Literature]
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8
[SID104234257]
EC50 0.02Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay [AID334278, Type: Literature]
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9
[SID104234257]
EC50 0.02Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay [AID334279, Type: Literature]
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10
[SID104234257]
EC50 0.02Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID334276, Type: Literature]
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11
[SID49718188]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID49718188]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID49718188]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID104234257]
EC50 0.04Antiproliferative activity against human A549 cells after 72 hrs by MTT assay [AID334277, Type: Literature]
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15
[SID104234257]
GI50 0.06Antitumor activity against human A549 cells after 72 hrs by SRB assay [AID613198, Type: Literature]
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16
[SID104234257]
IC50 0.08Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID478255, Type: Literature]
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17
[SID104234257]
IC50 0.08Cytotoxicity against human topotecan-resistant MCF7 cells after 72 hrs by MTT assay in presence of 1.2 mM BCRP inhibitor fumitremorgin C [AID478263, Type: Literature]
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18
[SID144205614]
Potency 0.0841qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID144205614]
Potency 0.0841qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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20
[SID144205614]
Potency 0.0841qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID104234257]
IC50 0.086Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay [AID478102, Type: Literature]
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22
[SID104234257]
GI50 0.09Antitumor activity against human MDA-MB-231 cells after 72 hrs by SRB assay [AID613196, Type: Literature]
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23
[SID855944]
Potency 0.0928Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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24
[SID104234257]
IC50 0.1Antiproliferative activity against mouse Colon 26-L5 cells assessed as cell viability after 72 hrs by MTT assay [AID357611, Type: Literature]
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25
[SID104234257]
ED50 0.1In vitro cytotoxicity against Leukemia L1210 cell line [AID246830, Type: Literature]
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26
[SID104234257]
GI50 0.1Cytotoxicity against human DWD cells by sulforhodamine B method [AID592935, Type: Literature]
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27
[SID104234257]
GI50 0.1Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID512055, Type: Literature]
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28
[SID104234257]
GI50 0.1Cytotoxicity against human A2780 cells after 48 hrs by SRB assay [AID512160, Type: Literature]
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29
[SID104234257]
GI50 0.1Anticancer activity against human ZR-75-1 cells after 48 hrs by SRB assay [AID512238, Type: Literature]
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30
[SID104234257]
GI50 0.1Anticancer activity against human A2780 cells after 48 hrs by SRB assay [AID512239, Type: Literature]
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31
[SID104234257]
IC50 0.1Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID566779, Type: Literature]
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32
[SID104234257]
GI50 0.1Cytotoxicity against human COLO205 cells after 48 hrs by sulforhoamine B based ELISA [AID592697, Type: Literature]
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33
[SID104234257]
GI50 0.1Cytotoxicity against human A549 cells after 48 hrs by sulforhoamine B based ELISA [AID592698, Type: Literature]
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34
[SID104234257]
GI50 0.1Cytotoxicity against human A2780 cells after 48 hrs by sulforhoamine B based ELISA [AID592699, Type: Literature]
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35
[SID104234257]
IC50 0.1Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID478254, Type: Literature]
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36
[SID104234257]
GI50 0.1Cytotoxicity against human A549 cells after 48 hrs by SRB assay [AID512017, Type: Literature]
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37
[SID104234257]
GI50 0.1Cytotoxicity against human DWD cells after 48 hrs by SRB assay [AID484659, Type: Literature]
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38
[SID49681823]
EC50 0.104Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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39
[SID144205614]
Potency 0.1059qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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40
[SID144205614]
Potency 0.1059qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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41
[SID144205614]
Potency 0.1059qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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42
[SID104234257]
EC50 0.11Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID334275, Type: Literature]
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43
[SID104234257]
GI50 0.12Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay [AID512019, Type: Literature]
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44
[SID104234257]
IC50 0.12Cytotoxicity against human 518A2 cells after 72 hrs by MTT assay [AID478252, Type: Literature]
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45
[SID104234257]
GI50 0.12Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay [AID512159, Type: Literature]
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46
[SID104234257]
GI50 0.12Cytotoxicity against human DWD cells after 48 hrs by SRB assay [AID512164, Type: Literature]
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47
[SID104234257]
GI50 0.13Cytotoxicity against human KB cells after 48 hrs by SRB assay [AID512161, Type: Literature]
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48
[SID104234257]
GI50 0.13Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay [AID569465, Type: Literature]
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49
[SID104234257]
IC50 0.13Cytotoxicity against human HL60 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay [AID592422, Type: Literature]
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50
[SID104234257]
GI50 0.13Cytotoxicity against human MCF7 cells after 48 hrs by sulforhoamine B based ELISA [AID592695, Type: Literature]
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