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Doxorubicin (CID 443939) - Compound BioActivity Data
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BioActivity Outcomes:
Active(802)
 
 
Inactive(807)
 
 
Inconclusive(189)
 
 
Unspecified(100)
 
 
Top Targets:
NR LBD PPAR(37)
 
 
 
 
7TM GPCR Srx(25)
 
 
 
7TM GPCR Srsx(25)
 
 
NR LBD AR(25)
 
 
 
 
NR LBD ER(25)
 
 
 
 
BioAssay Types:
Confirmatory(637)
 
 
 
 
 
Screening(627)
 
 
 
 
 
Literature(354)
 
 
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(535)
 
 
 
 
 
IC50(226)
 
 
 
 
 
EC50(24)
 
 
 
 
AC50(12)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1412    Data Row: 1898   Total Pages: 38   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144209681]
Potency-Replicate_1 0.0031qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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2
[SID104234257]
IC50 0.006Antiproliferative activity against human MV4-11 cells after 72 hrs by MTT assay [AID673199, Type: Literature]
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3
[SID144209681]
Potency-Replicate_1 0.0097qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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4
[SID104234257]
IC50 0.01Cytotoxicity against human KB cells after 48 hrs by MTT assay [AID718784, Type: Literature]
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5
[SID104234257]
IC50 0.01Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay [AID718786, Type: Literature]
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6
[SID104234257]
IC50 0.01Antiproliferative activity against human K562 cells after 48 hrs [AID494501, Type: Literature]
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7
[SID104234257]
IC50 0.01Cell growth inhibition of human K562 cells after 48 hrs [AID494520, Type: Literature]
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8
[SID104234257]
IC50 0.01Antiproliferative activity against human K562 cells after 48 hrs [AID303684, Type: Literature]
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9
[SID104234257]
IC50 0.01Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID333312, Type: Literature]
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10
[SID144205614]
Potency-Replicate_1 0.0106qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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11
[SID104234257]
IC50 0.012Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay [AID333313, Type: Literature]
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12
[SID104234257]
IC50 0.017In vitro inhibitory activity against cancerous P388 cell line [AID150546, Type: Literature]
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13
[SID104234257]
EC50 0.02Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID334276, Type: Literature]
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14
[SID104234257]
EC50 0.02Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay [AID334278, Type: Literature]
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15
[SID104234257]
EC50 0.02Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay [AID334279, Type: Literature]
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16
[SID49718188]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID144209681]
Potency-Replicate_1 0.0243qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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18
[SID104234257]
EC50 0.04Antiproliferative activity against human A549 cells after 72 hrs by MTT assay [AID334277, Type: Literature]
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19
[SID104234257]
GI50 0.06Antitumor activity against human A549 cells after 72 hrs by SRB assay [AID613198, Type: Literature]
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20
[SID104234257]
GI50 0.0603Growth inhibition of human A549 cells after 72 hrs by SRB assay [AID699781, Type: Literature]
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21
[SID104234257]
GI50 0.0655Growth inhibition of human SKBR3 cells after 72 hrs by SRB assay [AID699783, Type: Literature]
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22
[SID144205614]
Potency-Replicate_1 0.0668qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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23
[SID104234257]
IC50 0.08Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID478255, Type: Literature]
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24
[SID104234257]
IC50 0.08Cytotoxicity against human topotecan-resistant MCF7 cells after 72 hrs by MTT assay in presence of 1.2 mM BCRP inhibitor fumitremorgin C [AID478263, Type: Literature]
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25
[SID144205614]
Potency-Replicate_1 0.0841qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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26
[SID144205614]
Potency 0.0841qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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27
[SID104234257]
IC50 0.086Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay [AID478102, Type: Literature]
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28
[SID144209681]
Potency-Replicate_1 0.0862qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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29
[SID104234257]
GI50 0.09Antitumor activity against human MDA-MB-231 cells after 72 hrs by SRB assay [AID613196, Type: Literature]
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30
[SID855944]
Potency 0.0928Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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31
[SID104234257]
IC50 0.1Antiproliferative activity against mouse Colon 26-L5 cells assessed as cell viability after 72 hrs by MTT assay [AID357611, Type: Literature]
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32
[SID104234257]
ED50 0.1In vitro cytotoxicity against Leukemia L1210 cell line [AID246830, Type: Literature]
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33
[SID104234257]
GI50 0.1Cytotoxicity against human COLO205 cells after 48 hrs by sulforhoamine B based ELISA [AID592697, Type: Literature]
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34
[SID104234257]
GI50 0.1Cytotoxicity against human A549 cells after 48 hrs by sulforhoamine B based ELISA [AID592698, Type: Literature]
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35
[SID104234257]
GI50 0.1Cytotoxicity against human A2780 cells after 48 hrs by sulforhoamine B based ELISA [AID592699, Type: Literature]
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36
[SID104234257]
GI50 0.1Cytotoxicity against human DWD cells by sulforhodamine B method [AID592935, Type: Literature]
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37
[SID104234257]
IC50 0.1Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID566779, Type: Literature]
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38
[SID104234257]
IC50 0.1Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID478254, Type: Literature]
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39
[SID104234257]
GI50 0.1Cytotoxicity against human A549 cells after 48 hrs by SRB assay [AID512017, Type: Literature]
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40
[SID104234257]
GI50 0.1Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID512055, Type: Literature]
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41
[SID104234257]
GI50 0.1Cytotoxicity against human A2780 cells after 48 hrs by SRB assay [AID512160, Type: Literature]
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42
[SID104234257]
GI50 0.1Anticancer activity against human ZR-75-1 cells after 48 hrs by SRB assay [AID512238, Type: Literature]
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43
[SID104234257]
GI50 0.1Anticancer activity against human A2780 cells after 48 hrs by SRB assay [AID512239, Type: Literature]
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44
[SID104234257]
GI50 0.1Cytotoxicity against human DWD cells after 48 hrs by SRB assay [AID484659, Type: Literature]
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45
[SID49681823]
EC50_uM 0.104Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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46
[SID144205614]
Potency 0.1059qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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47
[SID104234257]
EC50 0.11Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay [AID334275, Type: Literature]
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48
[SID104234257]
IC50 0.11Cytotoxicity against human LoVo cells after 72 hrs by SRB assay [AID689429, Type: Literature]
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49
[SID104234257]
GI50 0.11Growth inhibition against human IGROV cells after 72 hrs by inverted microscopy [AID734086, Type: Literature]
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50
[SID104234257]
GI50 0.12Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay [AID512159, Type: Literature]
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