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l-Isoprenaline (CID 443372) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(392)
 
 
Inconclusive(84)
 
 
Unspecified(8)
 
 
Top Targets:
p450(36)
 
 
 
 
HSD10-like SD..(16)
 
 
 
7TM GPCR Srx(12)
 
 
 
PLN02808(10)
 
 
BRCT(8)
 
 
BioAssay Types:
Confirmatory(448)
 
 
 
 
Literature(14)
 
 
 
 
Screening(2)
 
 
 
BioActivity Types:
Potency(360)
 
 
 
 
EC50(3)
 
 
Ki(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 184    Data Row: 509   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103760809]
EC50 0.0022Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium. [AID42046, Type: Literature]
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2
[SID103760809]
EC50 0.003Activity for Beta-2 adrenergic receptor was assessed from effect on relaxation of guinea pig trachea. [AID40844, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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3
[SID103760809]
EC50 0.02Agonist activity at adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells assessed as stimulation of cAMP accumulation by radioimmunoassay in presence of 1 uM DPCPX [AID391616, Type: Literature]Beta-2 adrenergic receptor [gi:114766]
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4
[SID11114195]
Potency 0.0631qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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5
[SID103760809]
Ki 0.136Displacement of [125I](-)-iodopindolol from adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells [AID391614, Type: Literature]Beta-2 adrenergic receptor [gi:114766]
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6
[SID11111324]
Potency 0.1995qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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7
[SID11112573]
Potency 0.3162qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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8
[SID11111323]
Potency 0.3162qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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9
[SID11111324]
Potency 0.3162qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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10
[SID11111323]
Potency 0.5012qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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11
[SID11114195]
Potency 3.9811qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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12
[SID124880426]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID90340747]
Potency 5.0119qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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14
[SID124880426]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID90341495]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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16
[SID11114195]
Potency 9.9763qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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17
[SID11112573]
Potency 10qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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18
[SID90340747]
Potency 18.8876qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID11114195]
Potency 39.8107qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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20
[SID90340747]
Potency 39.8107Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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21
[SID11114195]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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22
[SID11114195]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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23
[SID11111324]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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24
[SID11114195]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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25
[SID11111323]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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26
[SID103760809]
Selectivity ratio, Ki for adrenergic beta2 receptor to EC50 for adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells [AID391626, Type: Literature]Beta-2 adrenergic receptor [gi:114766]
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27
[SID11114195]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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28
[SID103760809]
Change in Gibb's free energy at Low affinity beta-2-adrenoreceptor in the membranes of bovine skeletal muscle preparation [AID218845, Type: Literature]
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29
[SID103760809]
Change in Gibb's free energy at High affinity beta2- adrenoceptor in Chang living cells. [AID218847, Type: Literature]
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30
[SID103760809]
Change in Gibb's free energy at Low affinity beta-2-adrenoreceptor in the Chang living cells [AID218848, Type: Literature]
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31
[SID11112573]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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32
[SID11111323]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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33
[SID11111324]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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34
[SID90340747]
Potency 0.0095Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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35
[SID11111323]
Potency 5.0119qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
36
[SID90340747]
Potency 11.2202qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay [AID743205, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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37
[SID90340747]
Potency 11.2202qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay [AID743205, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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38
[SID11111323]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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39
[SID11111323]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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40
[SID90340747]
Potency 25.1189qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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41
[SID90341495]
Potency 31.6228qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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42
[SID11114195]
Potency 31.6228qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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43
[SID11114195]
Potency 39.8107qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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44
[SID11111324]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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45
[SID11112573]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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46
[SID11112573]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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47
[SID11112573]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
48
[SID124880426]
Potency qHTS for inhibitors of Vif-A3G interactions: Validation [AID588379, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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49
[SID90340747]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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50
[SID90341495]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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