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l-Isoprenaline (CID 443372) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(394)
 
 
Inconclusive(84)
 
 
Unspecified(8)
 
 
Top Targets:
p450(36)
 
 
 
 
HSD10-like SD..(16)
 
 
 
7TM GPCR Srx(13)
 
 
 
 
PLN02808(10)
 
 
BRCT(8)
 
 
BioAssay Types:
Confirmatory(450)
 
 
 
 
Literature(17)
 
 
 
 
Screening(2)
 
 
 
BioActivity Types:
Potency(362)
 
 
 
 
EC50(6)
 
 
Ki(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 188    Data Row: 514   Total Pages: 26   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103760809]
EC50 0.0022Activity for Beta-1 adrenergic receptor was assessed from ability to stimulate contractions in isolated guinea pig atrium. [AID42046, Type: Literature]
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2
[SID103760809]
EC50 0.003Activity for Beta-2 adrenergic receptor was assessed from effect on relaxation of guinea pig trachea. [AID40844, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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3
[SID103760809]
EC50 0.00794Agonist activity at human beta1 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay [AID1073602, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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4
[SID103760809]
EC50 0.02Agonist activity at adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells assessed as stimulation of cAMP accumulation by radioimmunoassay in presence of 1 uM DPCPX [AID391616, Type: Literature]Beta-2 adrenergic receptor [gi:114766]
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5
[SID103760809]
EC50 0.03981Agonist activity at human beta3 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay [AID1073601, Type: Literature]Beta-3 adrenergic receptor [gi:461604]
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6
[SID103760809]
EC50 0.03981Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay [AID1073604, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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7
[SID11114195]
Potency 0.0631qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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8
[SID103760809]
Ki 0.136Displacement of [125I](-)-iodopindolol from adrenergic beta2 receptor in Syrian hamster DDT1 MF2 cells [AID391614, Type: Literature]Beta-2 adrenergic receptor [gi:114766]
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9
[SID11111324]
Potency 0.1995qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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10
[SID11112573]
Potency 0.3162qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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11
[SID11111323]
Potency 0.3162qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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12
[SID11111324]
Potency 0.3162qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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13
[SID11111323]
Potency 0.5012qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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14
[SID11114195]
Potency 3.9811qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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15
[SID124880426]
Potency 4.7318qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID90340747]
Potency 5.0119qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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17
[SID124880426]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID90341495]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID11114195]
Potency 9.9763qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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20
[SID11112573]
Potency 10qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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