CHEMBL66247 (CID 44306093) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inconclusive(4)
 
 
Unspecified(11)
 
 
Top Targets:
FKBP C(1)
 
 
BioAssay Types:
Literature(18)
 
 
 
 
BioActivity Types:
IC50(2)
 
 
EC50(1)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 18    Data Row: 18   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103257848]
IC50 0.0002The compound was tested for its inhibitory activity against T-cell proliferation using murine splenic T-cells [AID142575, Type: Literature]
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2
[SID103257848]
EC50 0.0009Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506 [AID69104, Type: Literature]Peptidyl-prolyl cis-trans isomerase FKBP1A [gi:51702264]
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3
[SID103257848]
EC50 0.0009Effective concentration against FK506 binding protein 12 using [3H]-dihydro FK-506 [AID69104, Type: Literature]Peptidyl-prolyl cis-trans isomerase FKBP1A [gi:51702264]
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4
[SID103257848]
IC50 0.0148Inhibitory activity against Calcineurin (CaN phosphatase) [AID45444, Type: Literature]
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5
[SID103257848]
 In vivo immunosuppression in murine models by splenic T-cell proliferation assay after peroral administration [AID142574, Type: Literature]
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6
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for plasma drug level after intravenous administration at dose 5 mg/kg [AID188429, Type: Literature]
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7
[SID103257848]
 The compound was tested for % reduction of nephrotoxicity in rat after intravenous administration at dose 1.7 mg/kg [AID189527, Type: Literature]
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8
[SID103257848]
 Ratio of hypothermia (ED50) by Murine (ED50) in vivo [AID235600, Type: Literature]
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9
[SID103257848]
 In vivo immunosuppression in murine models by splenic T-cell proliferation assay after intravenous administration [AID142478, Type: Literature]
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10
[SID103257848]
 Cytotoxicity was determined by hypothermia induction after intravenous administration in rat [AID176525, Type: Literature]
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11
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for blood urea nitrogen levels after intravenous administration at dose 10 mg/kg [AID188414, Type: Literature]
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12
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for blood urea nitrogen levels after intravenous administration at dose 2.5 mg/kg [AID188415, Type: Literature]
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13
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for blood urea nitrogen levels after intravenous administration at dose 5 mg/kg [AID188421, Type: Literature]
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14
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for plasma drug level after intravenous administration at dose 10 mg/kg [AID188422, Type: Literature]
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15
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for plasma drug level after intravenous administration at dose 2.5 mg/kg [AID188423, Type: Literature]
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16
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for plasma drug level after intravenous administration at dose 20 mg/kg; ND denotes not determined [AID188426, Type: Literature]
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17
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for plasma drug level after intravenous administration at dose 40 mg/kg; ND denotes not determined [AID188428, Type: Literature]
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18
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for blood urea nitrogen levels after intravenous administration at dose 20 mg/kg; ND denotes not determined [AID188418, Type: Literature]
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19
[SID103257848]
 Tested for nephrotoxicity in Dawley rats and measured for blood urea nitrogen levels after intravenous administration at dose 40 mg/kg; ND denotes not determined [AID188420, Type: Literature]
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