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Staurosporine (CID 44299148) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(1347)
 
 
Inactive(25)
 
 
Inconclusive(34)
 
 
Unspecified(735)
 
 
Top Targets:
PKc(153)
 
 
 
 
PKc like(135)
 
 
 
 
 
STKc AGC(69)
 
 
 
PTKc Abl(36)
 
 
 
CYCLIN(30)
 
 
 
BioAssay Types:
Literature(1580)
 
 
 
 
 
BioActivity Types:
Kd(883)
 
 
 
 
IC50(525)
 
 
 
 
 
EC50(15)
 
 
 
Ki(10)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2005    Data Row: 2141   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103243222]
IC50 4e-06Cytotoxicity against human HeLa cells after 48 hrs by MTT assay [AID600820, Type: Literature]
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2
[SID103243222]
IC50 4e-06Cytotoxicity against human HeLa cells after 48 hrs by MTT assay [AID595221, Type: Literature]
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3
[SID103243222]
Kd 2e-05Average Binding Constant for SLK ; NA=Not Active at 10 uM [AID256578, Type: Literature]STE20-like serine/threonine-protein kinase [gi:74762732]
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4
[SID103243222]
Kd 2.4e-05Binding constant for SLK kinase domain [AID625086, Type: Literature]STE20-like serine/threonine-protein kinase [gi:74762732]
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5
[SID103243222]
Kd 2.4e-05Binding constant for SLK kinase domain [AID435832, Type: Literature]STE20-like serine/threonine-protein kinase [gi:74762732]
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6
[SID103243222]
Kd 3e-05Average Binding Constant for STK10 ; NA=Not Active at 10 uM [AID256604, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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7
[SID103243222]
Kd 3.7e-05Binding constant for LOK kinase domain [AID435677, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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8
[SID103243222]
Kd 3.7e-05Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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9
[SID103243222]
Kd 3.9e-05Binding constant for CAMKK1 kinase domain [AID625143, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 1 [gi:56404620]
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10
[SID103243222]
Kd 3.9e-05Binding constant for CAMKK1 kinase domain [AID435521, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 1 [gi:56404620]
View
11
[SID103243222]
Kd 5e-05Average Binding Constant for CAMKK1 ; NA=Not Active at 10 uM [AID256583, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 1 [gi:56404620]
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12
[SID103243222]
Kd 5e-05Average Binding Constant for CAMKK2 ; NA=Not Active at 10 uM [AID256580, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 2 [gi:317373374]
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13
[SID103243222]
IC50 7e-05Inhibition of ROS1 by HotSpot assay relative to control [AID429341, Type: Literature]
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14
[SID103243222]
IC50 8e-05Inhibition Protein kinase C (PKC) [AID165147, Type: Literature]
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15
[SID103243222]
Kd 8.6e-05Binding constant for SNARK kinase domain [AID625139, Type: Literature]NUAK family SNF1-like kinase 2 [gi:74761376]
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16
[SID103243222]
Kd 8.6e-05Binding constant for SNARK kinase domain [AID435559, Type: Literature]NUAK family SNF1-like kinase 2 [gi:74761376]
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17
[SID103243222]
Kd 0.0001Average Binding Constant for MARK2 ; NA=Not Active at 10 uM [AID256608, Type: Literature]Serine/threonine-protein kinase MARK2 [gi:62510922]
View
18
[SID103243222]
Kd 0.0001Average Binding Constant for CAMK2A ; NA=Not Active at 10 uM [AID256621, Type: Literature]Calcium/calmodulin-dependent protein kinase type II subunit alpha [gi:296434552]
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19
[SID103243222]
IC50 0.0001Inhibition of CAMK2B [AID350254, Type: Literature]
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20
[SID103243222]
IC50 0.0001Inhibition of CHK1 [AID350257, Type: Literature]
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21
[SID103243222]
IC50 0.0001Inhibition of PDGFRalpha [AID350286, Type: Literature]
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22
[SID103243222]
IC50 0.0001Inhibition of PHKgamma2 [AID350287, Type: Literature]
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23
[SID103243222]
IC50 0.0001Inhibition of RSK1 [AID350294, Type: Literature]
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24
[SID103243222]
IC50 0.0001Inhibition of SYK [AID350295, Type: Literature]
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25
[SID103243222]
Kd 0.00014Binding constant for PHKG2 kinase domain [AID435930, Type: Literature]Phosphorylase b kinase gamma catalytic chain, liver/testis isoform [gi:125536]
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26
[SID103243222]
Kd 0.00014Binding constant for PHKG2 kinase domain [AID624797, Type: Literature]Phosphorylase b kinase gamma catalytic chain, liver/testis isoform [gi:125536]
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27
[SID103243222]
IC50 0.00015Inhibition of JAK3 [AID350278, Type: Literature]
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28
[SID103243222]
Kd 0.00015Average Binding Constant for STK3_m ; NA=Not Active at 10 uM [AID256574, Type: Literature]Serine/threonine-protein kinase 3 [gi:46577548]
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29
[SID103243222]
Kd 0.00016Binding constant for CAMK2A kinase domain [AID624730, Type: Literature]Calcium/calmodulin-dependent protein kinase type II subunit alpha [gi:296434552]
View
30
[SID103243222]
Kd 0.00016Binding constant for CAMK2A kinase domain [AID435520, Type: Literature]Calcium/calmodulin-dependent protein kinase type II subunit alpha [gi:296434552]
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31
[SID103243222]
Kd 0.00016Binding constant for CAMKK2 kinase domain [AID625060, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 2 [gi:317373374]
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32
[SID103243222]
Kd 0.00016Binding constant for CAMKK2 kinase domain [AID435648, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 2 [gi:317373374]
View
33
[SID103243222]
Kd 0.00018Binding constant for MST2 kinase domain [AID625054, Type: Literature]Serine/threonine-protein kinase 3 [gi:46577700]
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34
[SID103243222]
Kd 0.00018Binding constant for MST2 kinase domain [AID435662, Type: Literature]Serine/threonine-protein kinase 3 [gi:46577700]
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35
[SID103243222]
IC50 0.00018Inhibition of FLT3 by colorimetric analysis [AID642585, Type: Literature]
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36
[SID103243222]
Kd 0.00019Binding constant for MST1 kinase domain [AID625055, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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37
[SID103243222]
Kd 0.00019Binding constant for full-length MST1 [AID435433, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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38
[SID103243222]
Kd 0.0002Average Binding Constant for STK4 ; NA=Not Active at 10 uM [AID256586, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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39
[SID103243222]
Kd 0.00022Binding constant for TAOK3 kinase domain [AID625101, Type: Literature]Serine/threonine-protein kinase TAO3 [gi:78099183]
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40
[SID103243222]
Kd 0.00022Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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41
[SID103243222]
Kd 0.00024Binding constant for ROCK2 kinase domain [AID624969, Type: Literature]Rho-associated protein kinase 2 [gi:269849761]
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42
[SID103243222]
Kd 0.00025Binding constant for PFCDPK1(P.falciparum) kinase domain [AID624759, Type: Literature]Calcium-dependent protein kinase 1 [gi:50401836]
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43
[SID103243222]
Kd 0.00025Binding constant for PRKCE kinase domain [AID435320, Type: Literature]Protein kinase C epsilon type [gi:400135]
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44
[SID103243222]
Kd 0.00025Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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45
[SID103243222]
Kd 0.00028Binding constant for ROCK1 kinase domain [AID625015, Type: Literature]Rho-associated protein kinase 1 [gi:47605999]
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46
[SID103243222]
IC50 0.00031Inhibition of PKA [AID350289, Type: Literature]
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47
[SID103243222]
Kd 0.00032Binding constant for CAMK2D kinase domain [AID435647, Type: Literature]Calcium/calmodulin-dependent protein kinase type II subunit delta [gi:116242602]
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48
[SID103243222]
Kd 0.00032Binding constant for CAMK2D kinase domain [AID624770, Type: Literature]Calcium/calmodulin-dependent protein kinase type II subunit delta [gi:116242602]
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49
[SID103243222]
Kd 0.00035Binding constant for EGFR(L858R,T790M) kinase domain [AID625004, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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50
[SID103243222]
IC50 0.00036Inhibition of CDK2/cyclinA [AID350256, Type: Literature]
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