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Staurosporine (CID 44299148) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Unspecified(9)
 
 
Top Targets:
STKc CDK5(9)
 
 
 
CDK5 activato..(6)
 
 
 
STKc MST4(2)
 
 
PTKc VEGFR2(1)
 
 
BioAssay Types:
Literature(22)
 
 
 
BioActivity Types:
Kd(5)
 
 
IC50(5)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 22   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103243222]
IC50 0.0012Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured after 90 mins by P33-radiolabeled assay [AID745524, Type: Literature]Cyclin-dependent kinase 5 activator 1 [gi:2498217]
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2
[SID103243222]
IC50 0.0012Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured after 90 mins by P33-radiolabeled assay [AID745524, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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3
[SID103243222]
EC50 0.02975NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: Literature]
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4
[SID103243222]
EC50 0.0547NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: Literature]
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5
[SID103243222]
Kd 0.084Binding constant for full-length CDK5 [AID436010, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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6
[SID103243222]
Kd 0.084Binding constant for CDK5 kinase domain [AID624970, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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7
[SID103243222]
Kd 0.089Average Binding Constant for CDK5; NA=Not Active at 10 uM [AID256616, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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8
[SID103243222]
IC50 0.1Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate after 20 mins by scintillation counting analysis in presence of 33P-ATP [AID767307, Type: Literature]Cyclin-dependent kinase 5 activator 1 [gi:2498217]
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9
[SID103243222]
IC50 0.1Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate after 20 mins by scintillation counting analysis in presence of 33P-ATP [AID767307, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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10
[SID103243222]
IC50 0.115Inhibition of Vascular endothelial growth factor receptor 2 (KDR) [AID241651, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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11
[SID103243222]
Kd 0.14Binding constant for full-length MST4 [AID435663, Type: Literature]Serine/threonine-protein kinase 26 [gi:73621232]
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12
[SID103243222]
Kd 0.14Binding constant for MST4 kinase domain [AID625103, Type: Literature]Serine/threonine-protein kinase 26 [gi:73621232]
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13
[SID103243222]
CC50 0.355NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: Literature]
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14
[SID103243222]
NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: Literature]
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15
[SID103243222]
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720063, Type: Literature]Cyclin-dependent kinase 5 activator 1 [gi:2498217]
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16
[SID103243222]
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720064, Type: Literature]Cyclin-dependent kinase 5 activator 1 [gi:2498217]
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17
[SID103243222]
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720065, Type: Literature]Cyclin-dependent kinase 5 activator 1 [gi:2498217]
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18
[SID103243222]
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720066, Type: Literature]Cyclin-dependent kinase 5 activator 1 [gi:2498217]
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19
[SID103243222]
Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720063, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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20
[SID103243222]
Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA [AID720064, Type: Literature]Cyclin-dependent-like kinase 5 [gi:4033704]
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