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ochratoxin A (CID 442530) - Compound BioActivity Data
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BioActivity Outcomes:
Active(27)
 
 
Inactive(57)
 
 
Inconclusive(24)
 
 
Unspecified(25)
 
 
Top Targets:
MFS(13)
 
 
 
NR LBD TR(6)
 
 
 
 
NR LBD PPAR(5)
 
 
 
 
KAZAL SLC21(5)
 
 
NR LBD VDR(3)
 
 
 
 
BioAssay Types:
Confirmatory(74)
 
 
 
 
Screening(17)
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(71)
 
 
 
 
IC50(3)
 
 
 
Ki(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 118    Data Row: 133   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103724058]
EC50 0.06Induction of apoptosis in human HepG2 cells assessed as caspase 3 activation after 24 hrs by fluorescence assay [AID456116, Type: Literature]
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2
[SID103724058]
IC50 0.3Cytotoxicity against human HepG2 cells after 48 hrs by WST8 assay [AID456115, Type: Literature]
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3
[SID26755748]
Potency 0.8913qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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4
[SID26755748]
Potency 0.8913qHTS assay for small molecule antagonists of glucocorticoid receptor signaling [AID588533, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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5
[SID26755748]
Potency 1.9953qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling [AID588537, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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6
[SID103724058]
Ki 6.30957Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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7
[SID26755747]
Potency 22.3872VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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8
[SID26755748]
Potency 39.8107qHTS assay for small molecule agonists of peroxisome proliferator-activated receptor delta signaling [AID588534, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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9
[SID26755748]
Potency 44.6684qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling [AID588545, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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10
[SID26755748]
Potency 44.6684qHTS assay for small molecule agonists of vitamin D receptor signaling [AID588543, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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11
[SID26755748]
Potency 44.6684qHTS assay for small molecule agonists of farnesoid X receptor signaling [AID588527, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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12
[SID26755748]
Potency 44.6684qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID26755748]
Potency 44.6684qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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14
[SID103724058]
Ki 48.9779Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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15
[SID48414248]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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16
[SID48414248]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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17
[SID48414248]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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18
[SID48414248]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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19
[SID85844004]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway [AID2313, Type: screening]
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20
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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21
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
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22
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
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23
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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24
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
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25
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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26
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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27
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
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28
[SID103724058]
Km 0.42TP_TRANSPORTER: uptake in OAT1-expressing S2 cells [AID679378, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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29
[SID103724058]
Km 0.57TP_TRANSPORTER: uptake in OAT1-expressing S1 cells [AID681744, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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30
[SID103724058]
Km 0.739TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678967, Type: other]Solute carrier family 22 member 8 [gi:81872813]
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31
[SID103724058]
Km 0.75TP_TRANSPORTER: uptake in OAT3-expressing S2 cells [AID681030, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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32
[SID103724058]
Km 2TP_TRANSPORTER: uptake in Oat5-expressing oocytes [AID678844, Type: other]Putative organic anion transporter 5 [gi:81891297]
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33
[SID103724058]
Km 2.1TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681739, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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34
[SID103724058]
Km 5.6TP_TRANSPORTER: uptake in OAT-K1-expressing MDCK cells [AID681578, Type: other]Solute carrier organic anion transporter family member 1A3 [gi:27735248]
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35
[SID103724058]
Km 16.6TP_TRANSPORTER: uptake in OAT-K2-expressing MDCK cells [AID681577, Type: other]Solute carrier organic anion transporter family member 1A3 [gi:27735248]
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36
[SID103724058]
Km 16.6TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID680235, Type: other]Solute carrier organic anion transporter family member 1A1 [gi:1171883]
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37
[SID103724058]
Km 22.9TP_TRANSPORTER: uptake in OAT4-expressing S2 cells [AID680163, Type: other]Solute carrier family 22 member 11 [gi:74734337]
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38
[SID103724058]
Km 29TP_TRANSPORTER: uptake in Oatp1-expressing CHO-03 cell [AID682135, Type: other]Solute carrier organic anion transporter family member 1A1 [gi:1171883]
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39
[SID103724058]
IC50 58TP_TRANSPORTER: inhibition of PAH uptake (PAH: 0.1uM) in membrane vesicles from MRP2-expressing HEK cells [AID679666, Type: other]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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40
[SID103724058]
IC50 2500Inhibition of Mycobacterium tuberculosis recombinant MBP-tagged MshC assessed as formation of fluorescently labeled Cys-GlcN-Ins by HPLC [AID590639, Type: Literature]L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase [gi:54042274]
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41
[SID103724058]
Activity of mouse Oat6 expressed in Xenopus oocytes assessed as drug uptake [AID360152, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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42
[SID103724058]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681141, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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43
[SID103724058]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678971, Type: other]Solute carrier family 22 member 11 [gi:74734337]
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44
[SID103724058]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681371, Type: other]Solute carrier family 22 member 7 [gi:81879627]
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45
[SID103724058]
Activity of mouse Oat1 expressed in Xenopus oocytes assessed as drug uptake [AID360153, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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46
[SID103724058]
Km TP_TRANSPORTER: uptake in membrane vesicles from MRP2-expressing HEK cells [AID679663, Type: other]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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47
[SID103724058]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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48
[SID103724058]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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49
[SID103724058]
TP_TRANSPORTER: inhibition of Taurocholate uptake (Taurocholate: 0.25 uM, OTA: 100 uM) in OAT-K1-expressing MDCK cells [AID679695, Type: other]Solute carrier organic anion transporter family member 1A3 [gi:27735248]
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50
[SID26755748]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View