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AGN-PC-00IQUF (CID 4425) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(7)
 
 
Unspecified(4)
 
 
Top Targets:
Myc N(1)
 
 
P53(1)
 
 
PTZ00435(1)
 
 
RHD-n NFkB1(1)
 
 
STAT bind(1)
 
 
BioAssay Types:
Screening(7)
 
 
Literature(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85209397]
Ligands of peptide (Class A) GPCRs [AID2063, Type: other]
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2
[SID103734615]
Partition coefficient (logP) [AID23717, Type: Literature]
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3
[SID103734615]
Binding constant for the agonist state was measured for its ability to displace [3H]naloxone from opioid mu 1 receptor buffered homogenate of rat brain membranes [AID151584, Type: Literature]
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4
[SID103734615]
Binding constant for the antagonist state was measured for its ability to displace [3H]naloxone from opioid mu 1 receptor buffered homogenate of rat brain membranes [AID151914, Type: Literature]
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5
[SID103734615]
pKa (acid-base dissociation constant) as determined by Luan ref: Pharm. Res. 2005 [AID781328, Type: Literature]
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6
[SID85788605]
Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based System Using Plate Reader - 7124-01_Inhibitor_SinglePoint_HTS_Activity [AID1053188, Type: screening]
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7
[SID85788605]
SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]signal transducer and activator of transcription 3 isoform 1 [Homo sapiens] [gi:21618340]
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8
[SID85788605]
NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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9
[SID85788605]
Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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10
[SID85788605]
SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]myc proto-oncogene protein [Homo sapiens] [gi:71774083]
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11
[SID85788605]
mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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12
[SID85788605]
Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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