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lyngbyastatin 3 (CID 44246697) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(157)
 
 
Inconclusive(9)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srsx(6)
 
 
RasGEF(4)
 
 
MH2 SMAD 2 3(4)
 
 
 
RING(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Confirmatory(101)
 
 
 
 
 
Screening(86)
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(93)
 
 
 
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 180    Data Row: 192   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85272968]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID85272968]
Potency 0.0326qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID85272968]
Potency 0.2909qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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4
[SID85272968]
Potency 0.3162qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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5
[SID85272968]
Potency 0.3663qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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6
[SID85272968]
Potency 0.5623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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7
[SID85272968]
Potency 0.8199qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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8
[SID85272968]
Potency 1.0323qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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9
[SID85272968]
Potency 1.0323Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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10
[SID85272968]
Potency 1.122qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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11
[SID85272968]
Potency 1.4581A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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12
[SID85272968]
Potency 1.4581Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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13
[SID85272968]
Potency 1.8356Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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14
[SID85272968]
Potency 22.3872qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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15
[SID85272968]
Potency 35.4813qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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16
[SID85272968]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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17
[SID85272968]
Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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18
[SID85272968]
Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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19
[SID85272968]
Single concentration confirmation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651995, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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20
[SID85272968]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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