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CHEMBL1088508 (CID 44246387) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(28)
 
 
Unspecified(2)
 
 
Top Targets:
GH31 MGAM SI..(4)
 
 
 
PLDc mTdp1 2(3)
 
 
ANK(2)
 
 
Pyr redox dim(2)
 
 
PIN FEN1(1)
 
 
BioAssay Types:
Confirmatory(30)
 
 
 
 
Screening(2)
 
 
Literature(1)
 
 
BioActivity Types:
Potency(30)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 32    Data Row: 33   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85267327]
Potency 7.9433Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase Using an Alternate Red Fluorescent Susbtrate [AID2110, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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2
[SID85267327]
Potency 31.6228Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate Using an Alternate Red Fluorescent Susbtrate [AID2111, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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3
[SID85267327]
Potency 31.6228Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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4
[SID85267327]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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5
[SID103755008]
Activation of purified human recombinant acid alpha-glucosidase using resorufin alpha-D-glucopyranoside as substrate at 100 uM after 45 mins relative to basal [AID478973, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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6
[SID85267327]
Potency Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease: Glucocerebrosidase Counter Screen [AID540341, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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7
[SID85267327]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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8
[SID85267327]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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9
[SID85267327]
Potency qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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10
[SID85267327]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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11
[SID85267327]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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12
[SID85267327]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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13
[SID85267327]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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14
[SID85267327]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID85267327]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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16
[SID85267327]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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17
[SID85267327]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID85267327]
Potency qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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19
[SID85267327]
Potency HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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20
[SID85267327]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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