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CHEMBL2203703 (CID 44241710) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(1)
 
 
Inconclusive(1)
 
 
Unspecified(6)
 
 
Top Targets:
7tm 4(3)
 
 
BioAssay Types:
Literature(24)
 
 
 
 
 
BioActivity Types:
Ki(10)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 24    Data Row: 24   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID163339174]
Ki 0.0007Displacement of radioligand [3H]osanetant at human NK3 Y315F6.51 mutant expressed in HEK293 cells [AID715705, Type: Literature]
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2
[SID163339174]
Ki 0.0007Binding affinity at human NK1 receptor [AID715896, Type: Literature]Substance-P receptor [gi:128359]
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3
[SID163339174]
Ki 0.0007Displacement of radioligand [3H]SP from wild type human NK1 receptor expressed in HEK293 cells [AID715708, Type: Literature]Substance-P receptor [gi:128359]
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4
[SID163339174]
Ki 0.0011Displacement of radioligand [3H]SP from human NK1 F264Y6.51 mutant expressed in HEK293 cells [AID715707, Type: Literature]
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5
[SID163339174]
Ki 0.0029Binding affinity to wild type human NK3 receptor [AID715671, Type: Literature]Neuromedin-K receptor [gi:128364]
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6
[SID163339174]
Ki 0.0029Displacement of [3H]osanetant from wild type human NK3 receptor expressed in HEK293 cells [AID715706, Type: Literature]Neuromedin-K receptor [gi:128364]
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7
[SID163339174]
Ki 0.0034Displacement of radioligand [3H]osanetant at human NK3 Y247W mutant expressed in HEK293 cells [AID715683, Type: Literature]
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8
[SID163339174]
Ki 0.0039Displacement of radioligand [3H]osanetant at human NK3 Y247F mutant expressed in HEK293 cells [AID715685, Type: Literature]
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9
[SID163339174]
Ki 0.0125Displacement of radioligand [3H]osanetant at human NK3 H316F mutant expressed in HEK293 cells [AID715682, Type: Literature]
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10
[SID163339174]
Kd 0.02884Partial noncompetitive inhibition of human F264Y6.51 mutant expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins [AID715899, Type: Literature]
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11
[SID163339174]
Ki 2.01Displacement of radioligand [3H]osanetant at human NK3 H316W mutant expressed in HEK293 cells [AID715680, Type: Literature]
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12
[SID163339174]
Noncompetitive inhibition at human NK3 Y315F6.51 mutant expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715713, Type: Literature]
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13
[SID163339174]
Antagonist activity at human NK3 Y315F6.51 mutant expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation at 10 nM after 20 mins [AID715703, Type: Literature]
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14
[SID163339174]
Noncompetitive inhibition at human NK3 Y247F5.38 mutant expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715709, Type: Literature]
View
15
[SID163339174]
Noncompetitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 mins [AID715901, Type: Literature]Substance-P receptor [gi:128359]
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16
[SID163339174]
Noncompetitive inhibition at wild type human NK3 expressed in HEK293 cells assessed as decrease in [MePhe7]NKB-induced [3H]IP accumulation after 20 mins [AID715714, Type: Literature]Neuromedin-K receptor [gi:128364]
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17
[SID163339174]
Selectivity ratio of Ki for wild type human NK3 receptor expressed in HEK293 cells to Ki for human NK3 Y315F6.51 mutant expressed in HEK293 cells [AID715704, Type: Literature]
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18
[SID163339174]
Inhibition of foot tapping response in po dosed gerbil [AID715668, Type: Literature]
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19
[SID163339174]
Selectivity ratio of Ki for human NK3 H316W mutant expressed in HEK293 cells to Ki for wild type human NK3 receptor expressed in HEK293 cells [AID715673, Type: Literature]
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20
[SID163339174]
Selectivity ratio of Ki for human NK3 H316F mutant expressed in HEK293 cells to Ki for wild type human NK3 receptor expressed in HEK293 cells [AID715674, Type: Literature]
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