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MLS002554296 (CID 44237404) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(2)
 
 
Active(23)
 
 
Inactive(187)
 
 
Inconclusive(5)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
 
7TM GPCR Srx(7)
 
 
ZnMc TACE lik..(6)
 
 
 
NR LBD ROR li..(6)
 
 
 
 
RasGEF(4)
 
 
 
BioAssay Types:
Screening(164)
 
 
 
 
Confirmatory(39)
 
 
 
 
Literature(9)
 
 
Summary(2)
 
 
BioActivity Types:
Potency(38)
 
 
 
 
EC50(2)
 
 
IC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 196    Data Row: 217   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85257298]
Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]nuclear receptor ROR-alpha isoform a [Homo sapiens] [gi:19743903]
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2
[SID85257298]
Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]nuclear receptor ROR-gamma isoform a [Homo sapiens] [gi:19743909]
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3
[SID85257298]
RORA (IC50) 2.47Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_1, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
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4
[SID99495593]
AbsAC40_uM 5.39Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_Dose_CherryPick_Activity [AID652053, Type: confirmatory]
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5
[SID99495593]
Potency 12.5893qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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6
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID99495593]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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9
[SID99455316]
Potency 18.1754VP16 selectivity assay for inhibitors of ROR gamma transcriptional activity [AID489036, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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10
[SID99455316]
Potency 18.1754ROR alpha selectivity assay for inhibitors of ROR gamma transcriptional activity [AID489039, Type: confirmatory]RAR-related orphan receptor alpha [Mus musculus] [gi:151357867]
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11
[SID99495593]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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12
[SID99495593]
Potency 19.9526qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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13
[SID99455316]
Potency 20.3931Secondary confirmation assay for inhibitors of ROR gamma transcriptional activity [AID489037, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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14
[SID99495593]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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15
[SID99495593]
Potency 35.4813qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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16
[SID99495593]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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17
[SID85257298]
Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_6, Type: screening]glucose-6-phosphatase [Homo sapiens] [gi:4557599]
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18
[SID99495593]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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19
[SID99495593]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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20
[SID99495593]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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