MLS002554296 (CID 44237404) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(17)
 
 
Inactive(139)
 
 
Inconclusive(4)
 
 
Top Targets:
7TM GPCR Srx(8)
 
 
NR LBD ROR li..(6)
 
 
 
 
7TM GPCR Srsx(4)
 
 
Peptidase M27(2)
 
 
NR DBD CAR(2)
 
 
BioAssay Types:
Screening(125)
 
 
 
 
Confirmatory(29)
 
 
 
 
Literature(3)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(28)
 
 
 
 
EC50(2)
 
 
IC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 155    Data Row: 161   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85257298]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
View
2
[SID85257298]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
View
3
[SID85257298]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
View
4
[SID85257298]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
View
5
[SID85257298]
IC50 2.47Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_1, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
6
[SID85257298]
IC50 2.47Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_1, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
7
[SID85257298]
IC50 2.47Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_1, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
8
[SID85257298]
IC50 2.47Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_1, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
9
[SID99495593]
AbsAC40_uM 5.39Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_Dose_CherryPick_Activity [AID652053, Type: confirmatory]
View
10
[SID99495593]
Potency 12.5893qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
11
[SID99495593]
Potency 12.5893qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
12
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
13
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
14
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
15
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
16
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
17
[SID99495593]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
18
[SID99495593]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
View
19
[SID99455316]
Potency 18.1754ROR alpha selectivity assay for inhibitors of ROR gamma transcriptional activity [AID489039, Type: confirmatory]RAR-related orphan receptor alpha [Mus musculus] [gi:151357867]
View
20
[SID99455316]
Potency 18.1754VP16 selectivity assay for inhibitors of ROR gamma transcriptional activity [AID489036, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
21
[SID99495593]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
22
[SID99495593]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
23
[SID99495593]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
24
[SID99495593]
Potency 19.9526qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
25
[SID99455316]
Potency 20.3931Secondary confirmation assay for inhibitors of ROR gamma transcriptional activity [AID489037, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
26
[SID99495593]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
27
[SID99495593]
Potency 35.4813qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
View
28
[SID99495593]
 Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
View
29
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_6, Type: screening]glucose-6-phosphatase [Homo sapiens] [gi:4557599]
View
30
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_6, Type: screening]glucose-6-phosphatase [Homo sapiens] [gi:4557599]
View
31
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_6, Type: screening]glucose-6-phosphatase [Homo sapiens] [gi:4557599]
View
32
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_6, Type: screening]glucose-6-phosphatase [Homo sapiens] [gi:4557599]
View
33
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
34
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
35
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
36
[SID85257298]
 Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117, Type: screening]retinoid-related orphan receptor alpha [Homo sapiens] [gi:216409696]
View
37
[SID99495593]
 Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
View
38
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_4, Type: screening]NR1H4 gene product [Homo sapiens] [gi:4826980]
View
39
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_4, Type: screening]NR1H4 gene product [Homo sapiens] [gi:4826980]
View
40
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_4, Type: screening]NR1H4 gene product [Homo sapiens] [gi:4826980]
View
41
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_4, Type: screening]NR1H4 gene product [Homo sapiens] [gi:4826980]
View
42
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_3, Type: screening]NR1H2 gene product [Homo sapiens] [gi:85362735]
View
43
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_3, Type: screening]NR1H2 gene product [Homo sapiens] [gi:85362735]
View
44
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_3, Type: screening]NR1H2 gene product [Homo sapiens] [gi:85362735]
View
45
[SID85257298]
EC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_3, Type: screening]NR1H2 gene product [Homo sapiens] [gi:85362735]
View
46
[SID85257298]
IC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_2, Type: screening]retinoid-related orphan receptor gamma [Homo sapiens] [gi:216409700]
View
47
[SID85257298]
IC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_2, Type: screening]retinoid-related orphan receptor gamma [Homo sapiens] [gi:216409700]
View
48
[SID85257298]
IC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_2, Type: screening]retinoid-related orphan receptor gamma [Homo sapiens] [gi:216409700]
View
49
[SID85257298]
IC50 20Late stage results from the probe development effort to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2117_2, Type: screening]retinoid-related orphan receptor gamma [Homo sapiens] [gi:216409700]
View
50
[SID99495593]
 S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
View