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MLS002639482 (CID 44229066) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(195)
 
 
Inconclusive(2)
 
 
Unspecified(3)
 
 
Top Targets:
7tm 4(17)
 
 
 
NACHT(7)
 
 
 
 
RasGEF(4)
 
 
NR DBD CAR(3)
 
 
Anthrax-tox M(3)
 
 
BioAssay Types:
Screening(148)
 
 
 
Confirmatory(43)
 
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(34)
 
 
 
IC50(12)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 193    Data Row: 207   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85248362]
IC50 2.481SAR analysis of NF-kB dependent luciferase using DAP as an inducer [AID2264, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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2
[SID85248362]
IC50_Mean 2.65SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID160698641]
IC50 2.7Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
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4
[SID85248362]
IC50_Mean 3.13SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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5
[SID99495607]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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6
[SID99495607]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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7
[SID99495607]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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8
[SID160698641]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
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9
[SID160698641]
IC50 20Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
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10
[SID160698641]
Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay [AID655846, Type: Literature]
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11
[SID85248362]
IC50_Mean 5SAR analysis of tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells. [AID2245, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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12
[SID85248362]
IC50_Mean 5SAR analysis of muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells. [AID2260, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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13
[SID85248362]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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14
[SID85248362]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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15
[SID85248362]
IC50 25SAR analysis of NF-kB dependent luciferase using Doxorucibin as an inducer [AID2255, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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16
[SID85248362]
IC50 25SAR analysis of NF-kB dependent luciferase using PMA/Ionomycin as an inducer [AID2261, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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17
[SID99495607]
Potency 50.1187qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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18
[SID99495607]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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19
[SID99495607]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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20
[SID99495607]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
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