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SureCN1675195 (CID 44223970) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(42)
 
 
Inactive(6)
 
 
Inconclusive(2)
 
 
Unspecified(3)
 
 
Top Targets:
PKc like(27)
 
 
 
STKc ERK1 2 l..(2)
 
 
PKc MKK5(1)
 
 
PI3Kc C2 gamm..(1)
 
 
PI3Kc C2 beta(1)
 
 
BioAssay Types:
Literature(23)
 
 
 
Confirmatory(20)
 
 
 
 
Summary(5)
 
 
 
BioActivity Types:
Potency(14)
 
 
 
 
Kd(13)
 
 
AC50(6)
 
 
 
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 48    Data Row: 54   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85239768]
qHTS for Inhibitors of DYRK1B: Summary [AID488883, Type: summary]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
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2
[SID124360162]
AC50_uM 0.00195MLPCN Dyrk1A - CLK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-05_Inhibitor_Dose_CherryPick_Activity [AID588811, Type: confirmatory]CDC-like kinase 1, isoform CRA_c [Homo sapiens] [gi:119590623]
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3
[SID131275786]
Kd 0.005Binding affinity to human Clk4 [AID594082, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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4
[SID124896715]
Potency 0.0052Reaction Biology data for inhibitors of DYRK1A: Probe SAR [AID624045, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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5
[SID124896715]
Potency 0.0093Reaction Biology data for inhibitors of CLK1: Probe SAR [AID624047, Type: confirmatory]dual specificity protein kinase CLK1 isoform 1 [Homo sapiens] [gi:67551261]
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6
[SID131275786]
IC50 0.011Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594050, Type: Literature]
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7
[SID131275786]
Kd 0.013Binding affinity to human Dyrk1A [AID594083, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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8
[SID131275786]
IC50 0.014Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594049, Type: Literature]
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9
[SID124896715]
Potency 0.0159Reaction Biology data for inhibitors of CLK4: Probe SAR [AID624034, Type: confirmatory]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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10
[SID124896715]
Potency 0.0164Reaction Biology data for inhibitors of DYRK1B: Probe SAR [AID624046, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
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11
[SID131275786]
Kd 0.018Binding affinity to human Clk1 [AID594080, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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12
[SID131275786]
IC50 0.02Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594076, Type: Literature]
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13
[SID124360162]
AC50_uM 0.0208MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-03_Inhibitor_Dose_CherryPick_Activity [AID588449, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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14
[SID131275786]
IC50 0.025Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594079, Type: Literature]
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15
[SID85239768]
Potency 0.0336Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay) [AID1970, Type: confirmatory]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
View
16
[SID131275786]
Kd 0.04Binding affinity to human PIK3C2G [AID594088, Type: Literature]Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [gi:313104205]
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17
[SID85239768]
Potency 0.0412Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay) [AID2705, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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18
[SID124896715]
Potency 0.04482Reaction Biology data for inhibitors of CLK2: Probe SAR [AID624048, Type: confirmatory]dual specificity protein kinase CLK2 [Homo sapiens] [gi:47717134]
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19
[SID131275786]
Kd 0.047Binding affinity to human Mek5 [AID594092, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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20
[SID131275786]
Kd 0.059Binding affinity to human Clk2 [AID594081, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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21
[SID131275786]
IC50 0.186Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594077, Type: Literature]
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22
[SID131275786]
Kd 0.19Binding affinity to human Ysk4 [AID594093, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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23
[SID131275786]
Kd 0.3Binding affinity to human Dyrk1B [AID594084, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1B [gi:9296963]
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24
[SID131275786]
Kd 0.34Binding affinity to human PIK3C2B [AID594087, Type: Literature]Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [gi:73920246]
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25
[SID131275786]
Kd 0.36Binding affinity to human PIP5K2C [AID594086, Type: Literature]Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [gi:317373532]
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26
[SID131275786]
Kd 0.37Binding affinity to human PIK3CG [AID594089, Type: Literature]Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [gi:92090623]
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27
[SID124896715]
Potency 0.4031Reaction Biology data for inhibitors of CLK3: Probe SAR [AID624049, Type: confirmatory]dual specificity protein kinase CLK3 isoform a [Homo sapiens] [gi:194097436]
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28
[SID131275786]
Kd 0.43Binding affinity to human Erk8 [AID594091, Type: Literature]Mitogen-activated protein kinase 15 [gi:74760462]
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29
[SID131275786]
Kd 0.48Binding affinity to human Dyrk2 [AID594085, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 2 [gi:148887370]
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30
[SID131275786]
IC50 1.924Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594078, Type: Literature]
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31
[SID85239768]
Potency 28.0703Secondary Assay for Inhibitors of Human Cdc-like kinase 4 (Clk4): HEK-293 Cell Viability Assay [AID504534, Type: confirmatory]
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32
[SID85239768]
Potency 89.1251qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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33
[SID85239768]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK3 isoform a [Homo sapiens] [gi:194097436]
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34
[SID85239768]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
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35
[SID131275786]
Chemical solubility of the compound [AID594094, Type: Literature]
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36
[SID85239768]
qHTS for Inhibitors of CDC-like Kinase 1 and 4: Summary [AID488887, Type: summary]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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37
[SID85239768]
qHTS for Inhibitors of CDC-like Kinase 4: Summary [AID1997, Type: summary]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
View
38
[SID85239768]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
View
39
[SID85239768]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
View
40
[SID85239768]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK2 [Homo sapiens] [gi:47717134]
View
41
[SID85239768]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK1 isoform 1 [Homo sapiens] [gi:67551261]
View
42
[SID85239768]
qHTS for Inhibitors of CDC-like Kinase 1 and 4: Summary [AID488887, Type: summary]dual specificity protein kinase CLK1 isoform 1 [Homo sapiens] [gi:67551261]
View
43
[SID85239768]
qHTS for Inhibitors of DYRK1A: Summary [AID488872, Type: summary]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
View
44
[SID131275786]
Apparent permeability from apical to basolateral side in human Caco2 cells [AID594095, Type: Literature]
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45
[SID131275786]
Apparent permeability from basolateral to apical side in human Caco2 cells [AID594096, Type: Literature]
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46
[SID131275786]
Aqueous stability of the compound in DPBS buffer at pH 7.4 after 48 hrs [AID594097, Type: Literature]
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47
[SID124360162]
AC50_uM MLPCN Dyrk1A - CDK2 selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-06_Inhibitor_Dose_CherryPick_Activity [AID602127, Type: confirmatory]cdk2 [Homo sapiens] [gi:312803]
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48
[SID85239768]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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49
[SID124360162]
AC50_uM MLPCN Dyrk1A Artifact Assay Measured in Biochemical System Using Plate Reader - 2124-04_Inhibitor_Dose_CherryPick_Activity [AID588432, Type: confirmatory]
View
50
[SID85239768]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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