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SureCN1675159 (CID 44223952) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(2)
 
 
Active(32)
 
 
Inactive(6)
 
 
Inconclusive(3)
 
 
Unspecified(3)
 
 
Top Targets:
PKc like(25)
 
 
 
STKc ERK1 2 l..(2)
 
 
WW(1)
 
 
PIPKc(1)
 
 
PLDc mTdp1 2(1)
 
 
BioAssay Types:
Confirmatory(20)
 
 
 
 
Literature(15)
 
 
 
Summary(5)
 
 
 
BioActivity Types:
Potency(14)
 
 
 
 
AC50(6)
 
 
 
IC50(6)
 
 
Kd(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 40    Data Row: 46   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85239750]
qHTS for Inhibitors of CDC-like Kinase 1 and 4: Summary [AID488887, Type: summary]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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2
[SID85239750]
qHTS for Inhibitors of CDC-like Kinase 1 and 4: Summary [AID488887, Type: summary]dual specificity protein kinase CLK1 isoform 1 [Homo sapiens] [gi:67551261]
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3
[SID124896713]
Potency 0.025Reaction Biology data for inhibitors of CLK4: Probe SAR [AID624034, Type: confirmatory]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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4
[SID124896713]
Potency 0.0304Reaction Biology data for inhibitors of CLK1: Probe SAR [AID624047, Type: confirmatory]dual specificity protein kinase CLK1 isoform 1 [Homo sapiens] [gi:67551261]
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5
[SID124896713]
Potency 0.0333Reaction Biology data for inhibitors of DYRK1A: Probe SAR [AID624045, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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6
[SID124360140]
AC50_uM 0.0354MLPCN Dyrk1A - CLK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-05_Inhibitor_Dose_CherryPick_Activity [AID588811, Type: confirmatory]CDC-like kinase 1, isoform CRA_c [Homo sapiens] [gi:119590623]
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7
[SID131279827]
IC50 0.04Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594050, Type: Literature]
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8
[SID131279827]
Kd 0.043Binding affinity to human Clk4 [AID594082, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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9
[SID85239750]
Potency 0.0475Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay) [AID1970, Type: confirmatory]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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10
[SID131279827]
Kd 0.05Binding affinity to human Clk1 [AID594080, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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11
[SID131279827]
Kd 0.082Binding affinity to human Dyrk1A [AID594083, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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12
[SID131279827]
IC50 0.096Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594076, Type: Literature]
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13
[SID124360140]
AC50_uM 0.168MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-03_Inhibitor_Dose_CherryPick_Activity [AID588449, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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14
[SID124896713]
Potency 0.1763Reaction Biology data for inhibitors of DYRK1B: Probe SAR [AID624046, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
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15
[SID124896713]
Potency 0.1868Reaction Biology data for inhibitors of CLK2: Probe SAR [AID624048, Type: confirmatory]dual specificity protein kinase CLK2 [Homo sapiens] [gi:47717134]
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16
[SID131279827]
IC50 0.206Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594049, Type: Literature]
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17
[SID131279827]
Kd 0.28Binding affinity to human PIP5K2C [AID594086, Type: Literature]Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [gi:317373532]
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18
[SID85239750]
Potency 0.2919Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay) [AID2705, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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19
[SID131279827]
Kd 0.38Binding affinity to human Clk2 [AID594081, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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20
[SID124896713]
Potency 1.264Reaction Biology data for inhibitors of CLK3: Probe SAR [AID624049, Type: confirmatory]dual specificity protein kinase CLK3 isoform a [Homo sapiens] [gi:194097436]
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21
[SID131279827]
IC50 1.327Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594077, Type: Literature]
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22
[SID131279827]
IC50 1.51Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594079, Type: Literature]
View
23
[SID131279827]
IC50 7.448Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594078, Type: Literature]
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24
[SID85239750]
Potency 79.4328qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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25
[SID85239750]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK3 isoform a [Homo sapiens] [gi:194097436]
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26
[SID131279827]
Chemical solubility of the compound [AID594094, Type: Literature]
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27
[SID85239750]
qHTS for Inhibitors of DYRK1B: Summary [AID488883, Type: summary]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
View
28
[SID85239750]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
View
29
[SID85239750]
qHTS for Inhibitors of DYRK1A: Summary [AID488872, Type: summary]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
View
30
[SID85239750]
qHTS for Inhibitors of CDC-like Kinase 4: Summary [AID1997, Type: summary]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
View
31
[SID85239750]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
View
32
[SID85239750]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
View
33
[SID85239750]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK2 [Homo sapiens] [gi:47717134]
View
34
[SID85239750]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity protein kinase CLK1 isoform 1 [Homo sapiens] [gi:67551261]
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35
[SID131279827]
Apparent permeability from apical to basolateral side in human Caco2 cells [AID594095, Type: Literature]
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36
[SID131279827]
Apparent permeability from basolateral to apical side in human Caco2 cells [AID594096, Type: Literature]
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37
[SID131279827]
Aqueous stability of the compound in DPBS buffer at pH 7.4 after 48 hrs [AID594097, Type: Literature]
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38
[SID124360140]
AC50_uM MLPCN Dyrk1A - CDK2 selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-06_Inhibitor_Dose_CherryPick_Activity [AID602127, Type: confirmatory]cdk2 [Homo sapiens] [gi:312803]
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39
[SID85239750]
Potency Secondary Assay for Inhibitors of Human Cdc-like kinase 4 (Clk4): HEK-293 Cell Viability Assay [AID504534, Type: confirmatory]
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40
[SID85239750]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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41
[SID124360140]
AC50_uM MLPCN Dyrk1A Artifact Assay Measured in Biochemical System Using Plate Reader - 2124-04_Inhibitor_Dose_CherryPick_Activity [AID588432, Type: confirmatory]
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42
[SID124360140]
AC50_uM MLPCN Dyrk1A - ERK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-07_Inhibitor_Dose_CherryPick_Activity_Set2 [AID602295, Type: confirmatory]mitogen-activated protein kinase 3 isoform 1 [Homo sapiens] [gi:91718899]
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43
[SID124360140]
AC50_uM MLPCN Dyrk1A - ERK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-07_Inhibitor_Dose_CherryPick_Activity [AID602348, Type: confirmatory]mitogen-activated protein kinase 3 isoform 1 [Homo sapiens] [gi:91718899]
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44
[SID85239750]
Potency 29.0929Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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45
[SID85239750]
Potency 50.1187qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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46
[SID85239750]
Potency 56.2341qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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