KUC103479N (CID 44216842) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(19)
 
 
Unspecified(1)
 
 
Top Targets:
Ras like GTPa..(6)
 
 
Rac1 like(4)
 
 
Rab7(3)
 
 
Cdc42(1)
 
 
GST N Mu(1)
 
 
BioAssay Types:
Confirmatory(13)
 
 
 
BioActivity Types:
EC50(13)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 18    Data Row: 26   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85231413]
EC50 0.332SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 [Homo sapiens] [gi:4757952]
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2
[SID85231413]
EC50 0.332SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 [Homo sapiens] [gi:4757952]
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3
[SID85231413]
EC50 0.507SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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4
[SID85231413]
EC50 5.495Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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5
[SID85231413]
EC50 10.471Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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6
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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7
[SID85231413]
 Actin Polymerization inhibition by compounds from Cdc42 Probe Extension Project [AID652107, Type: other]ACTB gene product [Homo sapiens] [gi:4501885]
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8
[SID85231413]
 Early assessment of compound stability in 1x PBS [AID493010, Type: other]
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9
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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10
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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11
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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12
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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13
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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14
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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15
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2 [gi:46577642]
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16
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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17
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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18
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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19
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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20
[SID85231413]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2041, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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21
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588393, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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22
[SID85231413]
 Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 1 [AID602137, Type: other]glutathione S-transferase [Homo sapiens] [gi:31933]
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23
[SID85231413]
 Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 1 [AID602137, Type: other]glutathione S-transferase [Homo sapiens] [gi:31933]
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24
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_8, Type: other]GTPase [Homo sapiens] [gi:407699]
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25
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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26
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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27
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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28
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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29
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
30
[SID85231413]
EC50 SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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31
[SID85231413]
 Cellular toxicity assessed by Trypan Blue for compounds in active Cdc42 Probe Extension Project [AID651732, Type: other]
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32
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_3, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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33
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_6, Type: other]ras protein [Homo sapiens] [gi:190938]
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34
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_7, Type: other]ras protein [Homo sapiens] [gi:190938]
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35
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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36
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_5, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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37
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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38
[SID85231413]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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