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MLS002630940 (CID 44216841) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(333)
 
 
Inconclusive(21)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(12)
 
 
Troponin(6)
 
 
 
APOBEC C(5)
 
 
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(262)
 
 
 
Confirmatory(110)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(95)
 
 
 
 
 
EC50(8)
 
 
IC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 345    Data Row: 381   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87349212]
Potency 2.9093A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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2
[SID87349212]
Potency 5.1735qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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3
[SID87349212]
Potency 10.3225qHTS for inhibitors of Vif-A3G interactions: Cherry picks [AID651812, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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4
[SID87349212]
Potency 11.2202qHTS for Inhibitors of Vif-A3F Interactions: qHTS [AID602313, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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5
[SID87349212]
Potency 16.3601qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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6
[SID87349212]
Potency 17.7111qHTS for small molecules that induce genotoxicity in ELG1 expressing cells: Confirmatory Assay for Cherry-picked Compounds [AID720565, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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7
[SID87349212]
Potency 18.3564A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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8
[SID87349212]
Potency 20.5878qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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9
[SID87349212]
Potency 20.5962qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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10
[SID87349212]
Luminescence-based cell-based high throughput confirmation assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID743050, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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11
[SID87349212]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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12
[SID87349212]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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13
[SID87349212]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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14
[SID87349212]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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15
[SID87349212]
Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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16
[SID87349212]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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17
[SID87349212]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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18
[SID87349212]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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19
[SID87349212]
Counterscreen for inhibitors of TLR9-MyD88 binding: luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to TLR9-MyD88 CHO cells [AID588336, Type: screening]
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20
[SID87349212]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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21
[SID87349212]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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22
[SID87349212]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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23
[SID87349212]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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24
[SID87349212]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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25
[SID87349212]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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26
[SID87349212]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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27
[SID87349212]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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28
[SID87349212]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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29
[SID87349212]
Potency 22.3872qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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30
[SID87349212]
Potency 22.3872qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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31
[SID87349212]
Potency 23.1093qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling: Hit Validation in Primary Screen [AID651558, Type: confirmatory]
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32
[SID87349212]
Potency 23.9341qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling: Hit Validation in Renilla Reporter Assay [AID651568, Type: confirmatory]
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33
[SID87349212]
Potency 28.1838qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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34
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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35
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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36
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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37
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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38
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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39
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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40
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
41
[SID85231412]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2041, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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42
[SID87349212]
Potency 31.6228qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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43
[SID87349212]
Potency 56.2341HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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44
[SID87349212]
Potency 56.2341qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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45
[SID87349212]
uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493012, Type: screening]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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46
[SID87349212]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
View
47
[SID87349212]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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48
[SID87349212]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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49
[SID87349212]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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50
[SID87349212]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon) [AID602123, Type: screening]DNA-binding ATP-dependent protease La [Escherichia coli str. K-12 substr. MG1655] [gi:16128424]
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