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MLS002474477 (CID 44202702) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(449)
 
 
Inconclusive(6)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(27)
 
 
ZnMc TACE lik..(8)
 
 
 
alkPPc(6)
 
 
 
ABCC CFTR1(5)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(345)
 
 
 
 
Confirmatory(98)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(86)
 
 
 
 
IC50(9)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 390    Data Row: 461   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85201618]
IC50 7.721Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 [AID743259, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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2
[SID85201618]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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3
[SID85201618]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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4
[SID85201618]
uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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5
[SID85201618]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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6
[SID85201618]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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7
[SID85201618]
IC50 69.493QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17 [AID743260, Type: confirmatory]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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8
[SID85201618]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE) [AID1053197, Type: screening]Sialate O-acetylesterase [gi:74734243]
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9
[SID85201618]
PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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10
[SID85791995]
PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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11
[SID85201618]
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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12
[SID85201618]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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13
[SID85201618]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM10. [AID743208, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
View
14
[SID85201618]
Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput screening assay to identify inhibitors of ADAM10 [AID743256, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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15
[SID85201618]
AC50_uM Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity [AID624273, Type: confirmatory]FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) [Mycobacterium tuberculosis H37Rv] [gi:1781172]
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16
[SID85201618]
Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1, partial [Homo sapiens] [gi:2358024]
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17
[SID85201618]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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18
[SID85201618]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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19
[SID85201618]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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20
[SID85201618]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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