Bookmark and Share

BioActivity Data for Compound MLS002473875 (CID 44202487)

BioActivity Outcomes:
Active(23)
 
 
Inactive(436)
 
 
Inconclusive(16)
 
 
Unspecified(3)
 
 
Top Targets:
7tm 4(27)
 
 
 
ABCC CFTR1(5)
 
 
Troponin(4)
 
 
MH2 SMAD 2 3(4)
 
 
 
 
ZnMc TACE lik..(4)
 
 
 
BioAssay Types:
Screening(342)
 
 
 
 
Confirmatory(112)
 
 
 
 
 
Literature(16)
 
 
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(120)
 
 
 
Toxicity(10)
 
 
 
ADME(2)
 
 
Cell-based(131)
 
 
 
 
Organism-base..(16)
 
 
 
BioActivity Types:
Potency(91)
 
 
 
 
 
IC50(15)
 
 
 
AC50(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 404    Data Row: 478   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134216488]
AC50_uM 0.000469Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID652275, Type: confirmatory]
View
2
[SID134216488]
AC50_uM 0.00152Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity [AID651845, Type: confirmatory]
View
3
[SID194147978]
IC50 0.002Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in mouse NIH/3T3 cells assessed as multimode parasite growth inhibition after 4 days by beta-galactosidase reporter gene assay [AID1065124, Type: Literature]
View
4
[SID134216488]
IC50_uM 0.0215Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_DryPowder_Activity [AID651890, Type: confirmatory]
View
5
[SID194147978]
IC50 0.031Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Tulahuen infected in rat L6 cells assessed as parasite growth inhibition after 96 hrs by beta-galactosidase reporter gene assay [AID1065122, Type: Literature]
View
6
[SID85201403]
AbsAC40_uM 2.42Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_Dose_CherryPick_Activity [AID652053, Type: confirmatory]
View
7
[SID85201403]
Potency 14.1254qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
8
[SID85201403]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
9
[SID85201403]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
10
[SID85201403]
Potency 23.1093qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
11
[SID85201403]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
View
12
[SID85201403]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
View
13
[SID85201403]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
View
14
[SID85201403]
TRFRET-based biochemical high throughput confirmation assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID602124, Type: screening]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
View
15
[SID85201403]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
View
16
[SID85201403]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ras and Rab interactor 1 [Homo sapiens] [gi:68989256]
View
17
[SID85201403]
TRFRET-based biochemical high throughput confirmation assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID602124, Type: screening]ras and Rab interactor 1 [Homo sapiens] [gi:68989256]
View
18
[SID85799652]
Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651903, Type: screening]
View
19
[SID85201403]
Counterscreen for IDE inhibitors: Luminescence-based cell-based high throughput assay to identify cytotoxic compounds using HEK cells [AID449730, Type: screening]
View
20
[SID194147978]
Solubility of the compound in phosphate buffer saline [AID1065123, Type: Literature]
View