MLS002473527 (CID 44202189) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(290)
 
 
Inconclusive(18)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
7TM GPCR Srsx(6)
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
Peptidase S9(3)
 
 
 
BioAssay Types:
Screening(235)
 
 
 
Confirmatory(84)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(68)
 
 
 
 
 
IC50(7)
 
 
AC50(3)
 
 
 
EC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 328    Data Row: 328   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85201104]
EC50 1.981Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504698, Type: confirmatory]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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2
[SID85201104]
AbsAC40_uM 3.348MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_Dose_CherryPick_Activity [AID540258, Type: confirmatory]
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3
[SID85201104]
EC50 9.149Counterscreen for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF): Fluorescence-based biochemical high throughput dose response assay to identify fluorescence artifacts [AID504697, Type: confirmatory]
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4
[SID85201104]
Potency 9.2A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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5
[SID85201104]
 Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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6
[SID85201104]
 Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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7
[SID85201104]
 Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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8
[SID85201104]
 Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID540251, Type: screening]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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9
[SID85201104]
 Counterscreen for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and receptor-interacting serine-threonine kinase 2 (RIPK2): Fluorescence-based cell-based high throughput assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID624371, Type: screening]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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10
[SID85201104]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the prolyl oligopeptidase-like enzyme (PREPL) [AID2751, Type: screening]Prolyl endopeptidase-like [Homo sapiens] [gi:153217451]
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11
[SID85201104]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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12
[SID85201104]
 Fluorescence-based cell-based high throughput confirmation assay for inhibitors of TLR9-MyD88 binding [AID540250, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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13
[SID85201104]
 Fluorescence-based cell-based high throughput confirmation assay for inhibitors of TLR9-MyD88 binding [AID540250, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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14
[SID85201104]
 Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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15
[SID85201104]
 Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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16
[SID85201104]
 DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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17
[SID85201104]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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18
[SID85201104]
 Fluorescence-based cell-based high throughput confirmation assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624370, Type: screening]RIPK2 gene product [Homo sapiens] [gi:4506537]
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19
[SID85201104]
 Fluorescence-based cell-based high throughput confirmation assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624370, Type: screening]RIPK2 gene product [Homo sapiens] [gi:4506537]
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20
[SID85201104]
 Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]RIPK2 gene product [Homo sapiens] [gi:4506537]
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21
[SID85201104]
 Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]RIPK2 gene product [Homo sapiens] [gi:4506537]
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22
[SID85201104]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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23
[SID85201104]
AbsAC40_uM Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_Dose_CherryPick_Activity [AID651717, Type: confirmatory]
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24
[SID85201104]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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25
[SID85201104]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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26
[SID85201104]
Potency 2.8184qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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27
[SID85201104]
Potency 10Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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28
[SID85201104]
Potency 10Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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29
[SID85201104]
Potency 22.3872qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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30
[SID85201104]
Potency 70.7946HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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31
[SID85201104]
 uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COPS5 gene product [Homo sapiens] [gi:38027923]
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32
[SID85201104]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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33
[SID85201104]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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34
[SID85201104]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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35
[SID85201104]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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36
[SID85201104]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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37
[SID85201104]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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38
[SID85201104]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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39
[SID85201104]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]Il2 gene product [Mus musculus] [gi:7110653]
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40
[SID85201104]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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41
[SID85201104]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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42
[SID85201104]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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43
[SID85201104]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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44
[SID85201104]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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45
[SID85201104]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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46
[SID85201104]
 qHTS Assay for Inhibitors of the Six1/Eya2 Interaction [AID651725, Type: screening]six1 [Homo sapiens] [gi:1246761]
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47
[SID85201104]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, i [gi:119579215]
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48
[SID85201104]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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49
[SID85201104]
 uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]CXCR6 gene product [Homo sapiens] [gi:5730106]
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50
[SID85201104]
 Turbidometric Biochemical Primary HTS to identify inhibitors of ERp5 Measured in Biochemical System Using Plate Reader - 7002-01_Inhibitor_SinglePoint_HTS_Activity [AID651711, Type: screening]Protein disulfide-isomerase A6 [gi:2501205]
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