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MLS002320359 (CID 44201857) - Compound BioActivity Data
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BioActivity Outcomes:
Active(29)
 
 
Inactive(374)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(30)
 
 
 
 
ABCC CFTR1(4)
 
 
 
CAP ED(4)
 
 
RasGEF(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(300)
 
 
 
 
Confirmatory(102)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(92)
 
 
 
 
 
IC50(7)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 375    Data Row: 417   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85200735]
Potency 1.299qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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2
[SID85200735]
Potency 2.807qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1 [AID624249, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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3
[SID85200735]
Potency 5.6007HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation [AID624248, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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4
[SID85200735]
Potency 5.6234qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor, partial [Homo sapiens] [gi:1724069]
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5
[SID85200735]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID85200735]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID85200735]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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8
[SID85200735]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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9
[SID85200735]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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10
[SID85200735]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID493034, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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11
[SID85200735]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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12
[SID85200735]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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13
[SID85200735]
Fluorescence-based cell-based high throughput confirmation assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID492963, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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14
[SID85200735]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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15
[SID85200735]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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16
[SID85200735]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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17
[SID85200735]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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18
[SID85200735]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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19
[SID85200735]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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20
[SID85200735]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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