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MLS002320020 (CID 44201587) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(363)
 
 
Inconclusive(12)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
 
7TM GPCR Srsx(12)
 
 
 
 
CAP ED(4)
 
 
Troponin(4)
 
 
ABCC CFTR1(4)
 
 
BioAssay Types:
Screening(281)
 
 
 
 
Confirmatory(100)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(87)
 
 
 
 
 
IC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 353    Data Row: 390   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85200465]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID85200465]
Potency 20.5878qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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3
[SID85200465]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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4
[SID85200465]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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5
[SID85200465]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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6
[SID85200465]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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7
[SID85200465]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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8
[SID85200465]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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9
[SID85200465]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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10
[SID85200465]
Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]5-hydroxytryptamine receptor 5A [Homo sapiens] [gi:13236497]
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11
[SID85200465]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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12
[SID85200465]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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13
[SID85200465]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID85200465]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_8, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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15
[SID85200465]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_10, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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16
[SID85200465]
Potency 4.4668qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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17
[SID85200465]
IC50_CXCR6_Mean 14.5Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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18
[SID85200465]
Potency 79.4328qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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19
[SID85200465]
C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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20
[SID85200465]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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21
[SID85200465]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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22
[SID85200465]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
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23
[SID85200465]
Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A) [AID623877, Type: screening]anoctamin-1 isoform 1 [Mus musculus] [gi:334278898]
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24
[SID85200465]
Potency qHTS for Inhibitors of KCHN2 3.1: Wildtype qHTS [AID720551, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:342840031]
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25
[SID85200465]
Potency qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS [AID720553, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:342840031]
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26
[SID85200465]
Potency qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction [AID624246, Type: confirmatory]transcriptional regulator ERG isoform 3 [Homo sapiens] [gi:343478176]
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27
[SID85200465]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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28
[SID85200465]
Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity [AID602481, Type: screening]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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29
[SID85200465]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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30
[SID85200465]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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31
[SID85200465]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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32
[SID85200465]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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33
[SID85200465]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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34
[SID85200465]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) [AID492972, Type: screening]platelet-activating factor acetylhydrolase IB subunit gamma [Homo sapiens] [gi:225543099]
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35
[SID85200465]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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36
[SID85200465]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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37
[SID85200465]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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38
[SID85200465]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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39
[SID85200465]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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40
[SID85200465]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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41
[SID85200465]
Potency qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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42
[SID85200465]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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43
[SID85200465]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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44
[SID85200465]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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45
[SID85200465]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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46
[SID85200465]
Potency HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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47
[SID85200465]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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48
[SID85200465]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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49
[SID85200465]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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50
[SID85200465]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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