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BioActivity Data for Compound STK646915 (CID 4419942)

BioActivity Outcomes:
Active(14)
 
 
Inactive(529)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(34)
 
 
TRP 2(20)
 
 
 
UBCc(5)
 
 
 
CAP ED(5)
 
 
Esterase lipa..(5)
 
 
BioAssay Types:
Screening(388)
 
 
 
 
Confirmatory(162)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(115)
 
 
 
Toxicity(7)
 
 
Cell-based(116)
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
Potency(121)
 
 
 
 
 
IC50(32)
 
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 511    Data Row: 564   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49817428]
IC50_Mean 0.927Dose response confirmation of HCS identification of small molecules that inhibit hepatic lipid droplet formation. [AID463191, Type: confirmatory]
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2
[SID49817428]
Potency 2.5018Confirmation Concentration-Response Assay for lipid storage modulators [AID1569, Type: confirmatory]
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3
[SID49817428]
Potency 3.5481qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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4
[SID49817428]
Potency 3.5481qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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5
[SID49817428]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID49817428]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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7
[SID49817428]
Absorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA) [AID602163, Type: screening]MSRA protein [Bos taurus] [gi:73586699]
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8
[SID49817428]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]Ubiquitin-like modifier activating enzyme 2 [Homo sapiens] [gi:13111961]
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9
[SID49817428]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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10
[SID49817428]
Single concentration confirmation of HCS identification of small molecules that inhibit hepatic lipid droplet formation [AID463183, Type: screening]
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11
[SID49817428]
Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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12
[SID49817428]
High Throughput Imaging Assay for Hepatic Lipid Droplet Formation [AID1656, Type: screening]
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13
[SID49817428]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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14
[SID49817428]
IC50 AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation [AID2018, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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15
[SID49817428]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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16
[SID49817428]
Potency 13.0918qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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17
[SID49817428]
Potency 28.1838qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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18
[SID49817428]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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19
[SID49817428]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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20
[SID49817428]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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