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MLS002472203 (CID 44144127) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(407)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
7TM GPCR Srsx(15)
 
 
ZnMc TACE lik..(6)
 
 
 
B zip1(4)
 
 
 
ABCC CFTR1(4)
 
 
BioAssay Types:
Screening(307)
 
 
 
Confirmatory(111)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 394    Data Row: 434   Total Pages: 22   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85148933]
IC50 7.724Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 [AID743259, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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2
[SID85148933]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID85148933]
Potency 11.2202qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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4
[SID85148933]
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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5
[SID85148933]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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6
[SID85148933]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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7
[SID85148933]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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8
[SID85148933]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID85148933]
IC50 69.513QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17 [AID743260, Type: confirmatory]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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10
[SID85148933]
HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 [AID540275, Type: screening]transient receptor potential cation channel subfamily V member 1 [Homo sapiens] [gi:74315350]
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11
[SID85148933]
HTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1 [AID540277, Type: screening]transient receptor potential cation channel subfamily V member 1 [Homo sapiens] [gi:74315350]
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12
[SID85148933]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE) [AID1053197, Type: screening]Sialate O-acetylesterase [gi:74734243]
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13
[SID85148933]
Single concentration validation of small molecule antagonists of the EBI2 receptor via a luminescent beta-galactosidase assay [AID652176, Type: screening]Beta-galactosidase [gi:75404427]
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14
[SID85148933]
PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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15
[SID85148933]
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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16
[SID85148933]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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17
[SID85148933]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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18
[SID85148933]
uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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19
[SID85148933]
Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_Activity [AID588549, Type: screening]FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) [Mycobacterium tuberculosis H37Rv] [gi:1781172]
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20
[SID85148933]
Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1, partial [Homo sapiens] [gi:2358024]
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