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AGN-PC-071JKY (CID 44143841) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(323)
 
 
Inconclusive(5)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(25)
 
 
Bcl-2 like(5)
 
 
 
RasGEF(4)
 
 
alkPPc(4)
 
 
CAP ED(4)
 
 
BioAssay Types:
Screening(231)
 
 
 
Confirmatory(107)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(87)
 
 
 
 
 
IC50(7)
 
 
EC50(6)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 313    Data Row: 353   Total Pages: 18   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85148499]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID85148499]
EC50_Mean 4.51Dose response confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489024, Type: confirmatory]
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3
[SID85148499]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID85148499]
EC50_Mean 7.24Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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5
[SID85148499]
EC50_Mean 11.2Dose response counterscreen of small molecule activators of the apoptotic arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489040, Type: confirmatory]
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6
[SID85148499]
Potency 11.2202qHTS for Inhibitors of Vif-A3F Interactions: qHTS [AID602313, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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7
[SID85148499]
Potency 12.5893qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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8
[SID85148499]
EC50_uM 75.81Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis [AID2765, Type: confirmatory]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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9
[SID85148499]
EC50_uM 75.81Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis [AID2765, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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10
[SID85148499]
AC50_uM 168.9Luminescence Cell-Based Secondary Screen to Identify Inhibitors of A1(alternate construct) [AID449757, Type: confirmatory]Bcl-2-like protein 11 [gi:18202042]
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11
[SID85148499]
AC50_uM 168.9Luminescence Cell-Based Secondary Screen to Identify Inhibitors of A1(alternate construct) [AID449757, Type: confirmatory]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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12
[SID85148499]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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13
[SID85148499]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]Chain A, Human Bcl2-A1 In Complex With Bim-Bh3 Peptide [gi:167013344]
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14
[SID85148499]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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15
[SID85148499]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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16
[SID85148499]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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17
[SID85148499]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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18
[SID85148499]
Single concentration confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463112, Type: screening]
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19
[SID85148499]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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20
[SID85148499]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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