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MLS002699036 (CID 44143698) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(205)
 
 
Inconclusive(8)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
7TM GPCR Srx(7)
 
 
RasGEF(4)
 
 
Rac1 like(3)
 
 
 
Toxin trans(3)
 
 
BioAssay Types:
Screening(150)
 
 
 
 
Confirmatory(45)
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(34)
 
 
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 196    Data Row: 220   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85148304]
EC50_MICROM 1.462Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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2
[SID85148304]
EC50_MICROM 1.589Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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3
[SID99495653]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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4
[SID99495653]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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5
[SID85148304]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_4, Type: other]
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6
[SID99495653]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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7
[SID99495653]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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8
[SID99495653]
Potency 10qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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9
[SID99495653]
Potency 15.8489qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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10
[SID99495653]
Potency 22.3872qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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11
[SID85148304]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2041, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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12
[SID85148304]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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13
[SID85148304]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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14
[SID85148304]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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15
[SID85148304]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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16
[SID85148304]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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17
[SID99495653]
S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4, partial [Homo sapiens] [gi:47496637]
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18
[SID99495653]
uHTS identification of small molecule activators of alpha dystroglycan glycosylation [AID624168, Type: screening]LARGE [Homo sapiens] [gi:47678551]
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19
[SID99495653]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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20
[SID99495653]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624126, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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