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AGN-PC-071JH2 (CID 44143697) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(13)
 
 
Inconclusive(3)
 
 
Top Targets:
Rac1 like(3)
 
 
 
ABC ATPase(2)
 
 
Rab2(1)
 
 
Rab7(1)
 
 
RhoGAP-p50rho..(1)
 
 
BioAssay Types:
Confirmatory(8)
 
 
 
BioActivity Types:
EC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 17   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85148303]
EC50_MICROM 2.992Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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2
[SID85148303]
EC50_MICROM 2.818Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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3
[SID85148303]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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4
[SID85148303]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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5
[SID85148303]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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6
[SID85148303]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2041, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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7
[SID85148303]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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8
[SID85148303]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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9
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_1, Type: other]
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10
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_2, Type: other]
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11
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_3, Type: other]
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12
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_4, Type: other]
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13
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_5, Type: other]
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14
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_6, Type: other]
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15
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393, Type: other]rho GTPase-activating protein 1 [Homo sapiens] [gi:4757766]
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16
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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17
[SID85148303]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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