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MLS002471441 (CID 44143082) - Compound BioActivity Data
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BioActivity Outcomes:
Active(62)
 
 
Inactive(290)
 
 
Inconclusive(34)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(25)
 
 
 
 
Peptidase C48(8)
 
 
 
WD40(6)
 
 
 
Troponin(6)
 
 
APOBEC C(5)
 
 
 
 
BioAssay Types:
Screening(254)
 
 
 
 
Confirmatory(117)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(13)
 
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 343    Data Row: 387   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85147291]
Potency 0.4449qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1 [AID624249, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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2
[SID85147291]
Potency 0.631qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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3
[SID85147291]
Potency 0.6513A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID85147291]
Potency 0.7051qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability [AID624251, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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5
[SID85147291]
Potency 0.8913qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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6
[SID85147291]
IC50_Mean 1.22Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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7
[SID85147291]
AC50_uM 1.517Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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8
[SID85147291]
IC50_Mean 2.22Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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9
[SID85147291]
IC50_Mean 2.22Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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10
[SID85147291]
Potency 2.3109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID85147291]
Potency 4.1078qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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12
[SID85147291]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID85147291]
AC50_uM 6.673Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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14
[SID85147291]
AC50_uM 7.362Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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15
[SID85147291]
Potency 7.9112HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation [AID624248, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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16
[SID85147291]
Potency 8.8766qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with Unstimulated Viability Assay [AID624252, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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17
[SID85147291]
Potency 12.5168qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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18
[SID85147291]
AC50_uM 13.69ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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19
[SID85147291]
Potency 14.0441qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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20
[SID85147291]
Potency 14.1254qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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