MLS002471441 (CID 44143082) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(55)
 
 
Inactive(247)
 
 
Inconclusive(26)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
Peptidase C48(8)
 
 
 
WD40(6)
 
 
 
APOBEC C(5)
 
 
 
 
7TM GPCR Srsx(4)
 
 
BioAssay Types:
Screening(222)
 
 
 
 
Confirmatory(97)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(78)
 
 
 
 
 
IC50(12)
 
 
 
 
AC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 329    Data Row: 329   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85147291]
Potency 0.4449qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1 [AID624249, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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2
[SID85147291]
Potency 0.631qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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3
[SID85147291]
Potency 0.6513A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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4
[SID85147291]
Potency 0.7051qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability [AID624251, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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5
[SID85147291]
Potency 0.8913qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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6
[SID85147291]
IC50 1.22Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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7
[SID85147291]
AC50 1.517Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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8
[SID85147291]
IC50 2.22Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
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9
[SID85147291]
IC50 2.22Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
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10
[SID85147291]
IC50 2.22Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
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11
[SID85147291]
IC50 2.22Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]CASP3 gene product [Homo sapiens] [gi:14790119]
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12
[SID85147291]
Potency 2.3109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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13
[SID85147291]
Potency 4.1078qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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14
[SID85147291]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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15
[SID85147291]
AC50 6.673Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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16
[SID85147291]
AC50 7.362Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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17
[SID85147291]
Potency 7.9112HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation [AID624248, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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18
[SID85147291]
Potency 8.8766qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with Unstimulated Viability Assay [AID624252, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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19
[SID85147291]
Potency 12.5168qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]APOBEC3F gene product [Homo sapiens] [gi:22907044]
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20
[SID85147291]
AC50 13.69ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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21
[SID85147291]
Potency 14.0441qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]APOBEC3F gene product [Homo sapiens] [gi:22907044]
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22
[SID85147291]
Potency 15.7578qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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23
[SID85147291]
Potency 15.785qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with 5FU Viability [AID624250, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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24
[SID85147291]
Potency 23.1093Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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25
[SID85147291]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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26
[SID85147291]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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27
[SID85147291]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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28
[SID85147291]
IC50 61.948Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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29
[SID85147291]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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30
[SID85147291]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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31
[SID85147291]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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32
[SID85147291]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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33
[SID85147291]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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34
[SID85147291]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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35
[SID85147291]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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36
[SID85147291]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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37
[SID85147291]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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38
[SID85147291]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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39
[SID85147291]
 Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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40
[SID85147291]
 uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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41
[SID85147291]
 Single concentration confirmation of uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID504614, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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42
[SID85147291]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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43
[SID85147291]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]NR5A2 gene product [Homo sapiens] [gi:4504343]
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44
[SID85147291]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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45
[SID85147291]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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46
[SID85147291]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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47
[SID85147291]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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48
[SID85147291]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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49
[SID85147291]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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50
[SID85147291]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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