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MLS002471402 (CID 44143049) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(377)
 
 
Inconclusive(16)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(12)
 
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(286)
 
 
 
 
Confirmatory(100)
 
 
 
 
 
Literature(15)
 
 
 
BioActivity Types:
Potency(86)
 
 
 
 
 
IC50(8)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 364    Data Row: 405   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85147258]
Potency 10qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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2
[SID85147258]
AC50_uM 11.98Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition Measured in Cell-Based System Using Plate Reader - 7011-01_Antagonist_Dose_CherryPick_Activity_Set2 [AID743343, Type: confirmatory]
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3
[SID85147258]
AC50_uM 17.91LGR2:Counterscreen with MC4R Measured in Cell-Based System Using Plate Reader - 7011-02_Antagonist_Dose_CherryPick_Activity [AID743444, Type: confirmatory]MSH [Drosophila melanogaster] [gi:1098680]
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4
[SID85147258]
Potency 19.9526HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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5
[SID85147258]
AC50_uM 44.32A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Antagonist_Dose_CherryPick_Activity [AID743412, Type: confirmatory]
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6
[SID85147258]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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7
[SID85147258]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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8
[SID123083503]
IC50 100Inhibition of CDK5/P25 GST-fusion protein assessed as substrate histone H1 phosphorylation by scintillation counting [AID551569, Type: Literature]
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9
[SID85147258]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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10
[SID123083503]
Activation of EGF-induced MEK1/2 activity in HEK293 cells assessed as phosphorylated ERK1/2 level at 10 uM after 1 hr by Western blotting relative to control [AID536055, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400274]
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11
[SID123083503]
Activation of EGF-induced MEK1/2 activity in HEK293 cells assessed as phosphorylated ERK1/2 level at 10 uM after 1 hr by Western blotting relative to control [AID536055, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 2 [gi:547915]
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12
[SID123083503]
Activation of EGF-induced MEK5 activity in HEK293 cells assessed as phosphorylated ERK5 level at 10 uM after 1 hr by Western blotting relative to control [AID536057, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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13
[SID85147258]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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14
[SID85147258]
Potency 39.8107qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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15
[SID85147258]
Potency 39.8107qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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16
[SID85147258]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
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17
[SID85147258]
Fluorescence Polarization with CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-02_Inhibitor_SinglePoint_HTS_Activity [AID602252, Type: screening]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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18
[SID85147258]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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19
[SID85147258]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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20
[SID85147258]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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