MLS002402727 (CID 44142732) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(345)
 
 
Inconclusive(6)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(8)
 
 
 
Peptidase C48(4)
 
 
alkPPc(4)
 
 
Pyr redox dim(3)
 
 
BioAssay Types:
Screening(256)
 
 
 
Confirmatory(88)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(78)
 
 
 
 
IC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 355    Data Row: 355   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85146876]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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2
[SID85146876]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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3
[SID85146876]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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4
[SID85146876]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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5
[SID85146876]
 Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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6
[SID124793496]
 A screen for small molecule inhibitors of the human deubiquitinating enzyme, UCH37 [AID588478, Type: other]ubiquitin C-terminal hydrolase UCH37 [Homo sapiens] [gi:4877999]
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7
[SID85146876]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID85146876]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID85146876]
Potency 0.5623qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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10
[SID85146876]
Potency 0.5623qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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11
[SID85146876]
Potency 35.4813qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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12
[SID85146876]
Potency qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID485294, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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13
[SID85146876]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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14
[SID85146876]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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15
[SID85146876]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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16
[SID85146876]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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17
[SID85146876]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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18
[SID85146876]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID85146876]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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20
[SID85146876]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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21
[SID85146876]
 C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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22
[SID85146876]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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23
[SID85146876]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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24
[SID85146876]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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25
[SID85146876]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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26
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
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27
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
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28
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
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29
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Single Point, Cherry Pick 1 [AID540358, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
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30
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Counterscreen, Cherry Pick 1 [AID588765, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
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31
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Counterscreen, Cherry Pick 1 [AID588765, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
32
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Counterscreen, Cherry Pick 1 [AID588765, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
33
[SID85146876]
 HTS for Beta-2AR agonists via FAP method, Counterscreen, Cherry Pick 1 [AID588765, Type: other]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
34
[SID85146876]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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35
[SID85146876]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
36
[SID85146876]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
37
[SID85146876]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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38
[SID85146876]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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39
[SID85146876]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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40
[SID85146876]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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41
[SID85146876]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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42
[SID85146876]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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43
[SID85146876]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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44
[SID85146876]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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45
[SID85146876]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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46
[SID85146876]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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47
[SID85146876]
 uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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48
[SID85146876]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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49
[SID85146876]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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50
[SID85146876]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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