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AGN-PC-071IET (CID 44142269) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(405)
 
 
Inconclusive(17)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(34)
 
 
 
RasGEF(4)
 
 
alkPPc(4)
 
 
Esterase lipa..(4)
 
 
ABCC CFTR1(4)
 
 
BioAssay Types:
Screening(307)
 
 
 
 
Confirmatory(114)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(100)
 
 
 
 
 
IC50(10)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 397    Data Row: 437   Total Pages: 22   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85146387]
AbsAC40_uM 0.184MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_Dose_CherryPick_Activity_Set6 [AID720513, Type: confirmatory]
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2
[SID85146387]
IC50 0.913Fluorescence-based biochemical high throughput dose response assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID652135, Type: confirmatory]fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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3
[SID85146387]
IC50 1.359Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluorescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) dose response assay to identify assay artifacts [AID652145, Type: confirmatory]
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4
[SID85146387]
Potency 4.6535Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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5
[SID85146387]
Potency 16.3535qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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6
[SID85146387]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID85146387]
Potency 19.9526qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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8
[SID85146387]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID85146387]
Potency 44.6684qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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10
[SID85146387]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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11
[SID85146387]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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12
[SID85146387]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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13
[SID85146387]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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14
[SID85146387]
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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15
[SID85146387]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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16
[SID85146387]
Potency 31.6228qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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17
[SID85146387]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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18
[SID85146387]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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19
[SID85146387]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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20
[SID85146387]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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