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miglitol (CID 441314) - Compound BioActivity Data
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BioActivity Outcomes:
Active(37)
 
 
Inactive(435)
 
 
Inconclusive(7)
 
 
Unspecified(48)
 
 
Top Targets:
GH31 MGAM SI..(20)
 
 
 
NR LBD PPAR(14)
 
 
 
7TM GPCR Srx(12)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(227)
 
 
 
 
Confirmatory(180)
 
 
 
 
Literature(79)
 
 
 
 
Summary(24)
 
 
BioActivity Types:
Potency(145)
 
 
 
 
IC50(61)
 
 
 
 
EC50(9)
 
 
Ki(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 491    Data Row: 527   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103582154]
IC50 0.11Inhibition of rat intestinal brush border membrane sucrase [AID342797, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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2
[SID103582154]
Ki 0.13Inhibition of mouse his-tagged ctSI expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620763, Type: Literature]
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3
[SID103582154]
Ki 0.148Inhibition of human ntSI expressed in Drosophila S2 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620764, Type: Literature]
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4
[SID103582154]
Ki 0.211Inhibition of mouse his-tagged ctMGAM-N2 expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620760, Type: Literature]
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5
[SID103582154]
Ki 0.23Inhibition of mouse his-tagged ctMGAM-N20 expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620761, Type: Literature]
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6
[SID103582154]
IC50 0.35Inhibition of human lysosomal alpha-glucosidase [AID342799, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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7
[SID103582154]
IC50 0.39Inhibition of rabbit muscle amylo-1,6-glucosidase [AID342805, Type: Literature]Glycogen debranching enzyme [gi:544379]
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8
[SID103582154]
Ki 0.46Competitive inhibition of rat intestinal maltase by Lineweaver-Burk plot analysis [AID710939, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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9
[SID103582154]
IC50 0.5Inhibition of sucrase by HPLC [AID466667, Type: Literature]
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10
[SID103582154]
IC50 0.59Inhibition of Wistar rat small intestine maltase after 30 mins [AID550393, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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11
[SID103582154]
IC50 1Inhibition of Wistar rat small intestine sucrase after 30 mins [AID550397, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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12
[SID103582154]
Ki 1Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay [AID536212, Type: Literature]Maltase-glucoamylase, intestinal [gi:215274260]
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13
[SID103582154]
IC50 1Inhibition of maltase in human Caco-2 cell model system after 2 hrs [AID342811, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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14
[SID103582154]
Ki 1Inhibition of human ntMGAM expressed in Drosophila S2 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620762, Type: Literature]
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15
[SID103582154]
IC50 1Inhibition of rat intestinal sucrase using sucrose as substrate [AID711102, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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16
[SID103582154]
IC50 1.2Inhibition of rat intestinal brush border membrane isomaltase [AID342795, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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17
[SID103582154]
IC50 1.3Inhibition of rat intestinal maltase using moltose as substrate [AID711104, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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18
[SID103582154]
IC50 1.3Inhibition of rat intestinal brush border membrane maltase [AID342793, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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19
[SID103582154]
IC50 1.3Inhibition of rat N-terminal maltase-glucoamylase catalytic domain [AID710938, Type: Literature]
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20
[SID103582154]
IC50 2Inhibition of lysosomal alpha-glucosidase by HPLC [AID466672, Type: Literature]
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21
[SID26719889]
Potency 2.2387qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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22
[SID26719889]
Potency 2.2387qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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23
[SID26719889]
Potency 3.5481qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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24
[SID103582154]
IC50 6Inhibition of maltase by HPLC [AID466668, Type: Literature]
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25
[SID103582154]
IC50 39Inhibition of rat intestinal isomaltase using isomoltose as substrate [AID711103, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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26
[SID103582154]
IC50 39Inhibition of Wistar rat small intestine isomaltase after 30 mins [AID550395, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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27
[SID103582154]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in blood insulin at 100 mg/kg/day for 4 weeks [AID466853, Type: Literature]
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28
[SID103582154]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as insulin resistance at 100 mg/kg/day for 4 weeks by HOMA-IR analysis [AID466855, Type: Literature]
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29
[SID103582154]
Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in HbA1c at 100 mg/kg/day for 4 weeks [AID466856, Type: Literature]
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30
[SID48416282]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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31
[SID49681630]
Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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32
[SID103582154]
Lysosomal alpha-glucosidase inhibitor [AID742963, Type: other]Lysosomal alpha-glucosidase [gi:317373572]
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33
[SID103582154]
Inhibition of alpha-glucosidase in human HepG2 cells assessed as increase in expression of immature high mannose type N-linked oligosachcharides at 500 uM after 48 hrs by MALDI-TOF MS analysis relative to untreated control [AID710949, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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34
[SID103582154]
Antihyperglycemic activity in overnight fasted ddY mouse assessed as decrease in blood glucose level at 3 to 5 mg/kg administered via stomach tube measured at 15 to 30 mins by maltose loading test relative to control [AID710946, Type: Literature]
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35
[SID103582154]
Maltase-glucoamylase inhibitor [AID742954, Type: other]Maltase-glucoamylase, intestinal [gi:215274260]
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36
[SID49681630]
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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37
[SID49681630]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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38
[SID103582154]
IC50 50Inhibition of lactase by HPLC [AID466669, Type: Literature]
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39
[SID103582154]
IC50 84Inhibition of human lysosomal beta-glucosidase [AID342801, Type: Literature]Glucosylceramidase [gi:55584151]
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40
[SID103582154]
IC50 200Inhibition of GBA1 by HPLC [AID466670, Type: Literature]
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41
[SID103582154]
IC50 700Inhibition of pig kidney trehalase assessed as p-nitrophenol release by spectrophotometrically [AID338569, Type: Literature]
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42
[SID103582154]
IC50 1000Inhibition of GCS by cell-based assay [AID466666, Type: Literature]
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43
[SID103582154]
IC50 9900Inhibition of baker's yeast alpha-glucosidase by 4-nitrophenolate-based assay [AID441055, Type: Literature]Oligo-1,6-glucosidase IMA1 [gi:1708944]
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44
[SID103582154]
Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release at 1000 uM by spectrophotometrically [AID338564, Type: Literature]Alpha-glucosidase MAL62 [gi:126716]
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45
[SID103582154]
Selectivity ratio of Ki for human ntMGAM to Ki for mouse ctMGAM-N2 [AID620765, Type: Literature]
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46
[SID103582154]
Selectivity ratio of Ki for human ntMGAM to Ki for mouse ctMGAM-N20 [AID620768, Type: Literature]
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47
[SID103582154]
Selectivity ratio of Ki for human ntMGAM to Ki for mouse ctSI [AID620771, Type: Literature]
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48
[SID103582154]
Selectivity ratio of Ki for human ntMGAM to Ki for human ntSI [AID620826, Type: Literature]
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49
[SID103582154]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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50
[SID103582154]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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