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UNII-DE4G8X55F5 (CID 44129648) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(3)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
 
BioAssay Types:
Literature(21)
 
 
 
 
BioActivity Types:
Ki(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 21    Data Row: 21   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136928384]
Ki 0.000597Binding affinity to human cloned KOR in presence of Na+/GDP [AID727333, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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2
[SID136928384]
Ki 0.000949Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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3
[SID136928384]
Ki 0.0164Binding affinity to human cloned MOR in presence of Na+/GDP [AID727334, Type: Literature]Mu-type opioid receptor [gi:2851402]
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4
[SID136928384]
Ki 0.0227Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID136928384]
Ki 0.122Binding affinity to human cloned DOR in presence of Na+/GDP [AID727332, Type: Literature]Delta-type opioid receptor [gi:311033488]
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6
[SID136928384]
Ki 0.166Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
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7
[SID136928384]
Antagonist activity at human cloned DOR assessed as inhibition of DPDPE-stimulated [35S]GTPgammaS binding after 4 hrs by scintillation counting analysis [AID727335, Type: Literature]Delta-type opioid receptor [gi:311033488]
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8
[SID136928384]
Antagonist activity at human opioid kappa receptor expressed in CHO cells assessed as inhibition of U69593-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631364, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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9
[SID136928384]
Antagonist activity at human cloned KOR assessed as inhibition of U69593-stimulated [35S]GTPgammaS binding after 4 hrs by scintillation counting analysis [AID727336, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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10
[SID136928384]
Antagonist activity at human opioid delta receptor expressed in HEK293 cells assessed as inhibition of DPDPE-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631347, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
11
[SID136928384]
Antagonist activity at human opioid mu receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTP-gamma-S binding after 4 hrs by scintillation counting [AID631365, Type: Literature]Mu-type opioid receptor [gi:2851402]
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12
[SID136928384]
Antagonist activity at human cloned MOR assessed as inhibition of DAMGO-stimulated [35S]GTPgammaS binding after 4 hrs by scintillation counting analysis [AID727338, Type: Literature]Mu-type opioid receptor [gi:2851402]
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13
[SID136928384]
Selectivity ratio of Kb for human opioid mu receptor expressed in CHO cells to Kb for human opioid kappa receptor expressed in CHO cells [AID631348, Type: Literature]
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14
[SID136928384]
Selectivity ratio of Ki for human opioid mu receptor expressed in CHO cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631362, Type: Literature]
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15
[SID136928384]
Selectivity ratio of Ki for human opioid delta receptor expressed in HEK293 cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631363, Type: Literature]
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16
[SID136928384]
Selectivity ratio of Kb for human opioid delta receptor expressed in HEK293 cells to Kb for human opioid kappa receptor expressed in CHO cells [AID631391, Type: Literature]
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17
[SID136928384]
In vivo receptor occupancy at MOR in po dosed Harlan Sprague-Dawley rat brain after 5.5 hrs by LC/MS/MS analysis [AID727330, Type: Literature]
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18
[SID136928384]
In vivo receptor occupancy at DOR in po dosed Harlan Sprague-Dawley rat brain after 5.5 hrs by LC/MS/MS analysis [AID727331, Type: Literature]
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19
[SID136928384]
Agonist activity at human opioid mu receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631393, Type: Literature]Mu-type opioid receptor [gi:2851402]
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20
[SID136928384]
Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding at 10 uM [AID631392, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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