CHEMBL562164 (CID 44129622) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inconclusive(1)
 
 
Unspecified(3)
 
 
Top Targets:
M1 LTA4H(2)
 
 
BioAssay Types:
Literature(4)
 
 
 
BioActivity Types:
IC50(3)
 
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 4    Data Row: 4   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103684039]
IC50 966Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupole mass spectrometry [AID420375, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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2
[SID103684039]
IC50 1491Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE [AID420374, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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3
[SID103684039]
 Solubility in methanol [AID420373, Type: Literature]
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4
[SID103684039]
IC50 Inhibition of ionomycin-stimulated LTB4 production in human whole blood treated 15 mins prior to ionomycin challenge measured after 30 mins of stimulation by enzyme-linked immunosorbent assay [AID420376, Type: Literature]
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