Saquinavir (CID 441243) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(297)
 
 
Inactive(439)
 
 
Inconclusive(21)
 
 
Unspecified(448)
 
 
Top Targets:
7TM GPCR Srx(29)
 
 
 
 
ABC MTABC3 MD..(22)
 
 
7TM GPCR Srsx(16)
 
 
 
p450(13)
 
 
 
SAP like(6)
 
 
 
BioAssay Types:
Literature(579)
 
 
 
 
 
Screening(315)
 
 
 
Confirmatory(130)
 
 
 
 
 
BioActivity Types:
IC50(243)
 
 
 
 
EC50(117)
 
 
 
 
 
Potency(95)
 
 
 
 
 
Ki(42)
 
 
 
Kd(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1203    Data Row: 1205   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179606]
Ki 4e-05Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assay [AID343014, Type: Literature]
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2
[SID103179606]
Ki 4e-05Inhibition of HIV protease [AID160300, Type: Literature]Pol polyprotein [gi:75593047]
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3
[SID103179606]
Ki 6.2e-05Dissociation constant obtained by inhibition of Wild-type protease [AID219260, Type: Literature]
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4
[SID103179606]
Ki 8e-05Inhibition of HIV1 protease [AID374591, Type: Literature]
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5
[SID103179606]
Ki 0.00012Compound was tested for its inhibitory potency against human immunodeficiency virus -1 (HIV-1 protease); In house preparation [AID82624, Type: Literature]
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6
[SID103179606]
Ki 0.00012Binding activity against HIV-1 Protease [AID163470, Type: Literature]
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7
[SID103179606]
Ki 0.00012The compound was tested for binding activity against HIV-1 protease [AID163472, Type: Literature]
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8
[SID103179606]
Ki 0.000138Inhibition of HIV1 protease [AID321660, Type: Literature]
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9
[SID103179606]
Ki 0.00019Inhibitory activity against HIV-1 protease [AID160477, Type: Literature]
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10
[SID103179606]
IC50 0.0002In vitro inhibition HIV-1 IIIB protease. [AID82291, Type: other]
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11
[SID103179606]
EC50 0.0002Antiviral activity against HIV2 ROD with protease V47A mutation infected in human CEM cells assessed as inhibition of virus production after 7 days by Lenti-RT activity assay [AID369953, Type: Literature]
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12
[SID103179606]
EC50 0.0002Antiviral activity against HIV2 ROD with protease G17N/V47A mutation infected in human CEM cells assessed as inhibition of virus production after 7 days by Lenti-RT activity assay [AID369954, Type: Literature]
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13
[SID103179606]
Ki 0.0002Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assay [AID443165, Type: Literature]
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14
[SID103179606]
Ki 0.00022Inhibition of HIV1 recombinant protease V32I/I47A mutant expressed in Escherichia coli by spectrophotometric assay [AID343018, Type: Literature]
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15
[SID103179606]
IC50 0.00023Tested for inhibitory concentration against HIV-1 protease [AID162380, Type: Literature]
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16
[SID103179606]
Ki 0.00023Inhibition constant for human immunodeficiency virus type 1 protease [AID238682, Type: Literature]
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17
[SID103179606]
Ki 0.00023Inhibition constant against HIV-1 Protease [AID160455, Type: Literature]Pol polyprotein [gi:75593047]
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18
[SID103179606]
IC50 0.00023Tested against S2-binding site of HIV-1 protease [AID162376, Type: Literature]Pol polyprotein [gi:75593047]
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19
[SID103179606]
Ki 0.00023Inhibitory concentration against HIV-1 protease [AID160481, Type: Literature]Pol polyprotein [gi:75593047]
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20
[SID103179606]
Ki 0.00025Affinity against HIV protease [AID162710, Type: Literature]Pol polyprotein [gi:75593047]
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21
[SID103179606]
Ki 0.00025Binding affinity to inhibit the purified wild-type HIV-1 Protease [AID160316, Type: Literature]Pol polyprotein [gi:75593047]
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22
[SID103179606]
Ki 0.00025Inhibitory activity against HIV-1 protease [AID163487, Type: Literature]Pol polyprotein [gi:75593047]
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23
[SID103179606]
Kd 0.00031Binding affinity for human immunodeficiency virus type 1 protease [AID238043, Type: Literature]
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24
[SID103179606]
Kd 0.000315Equilibrium constant for the interaction between inhibitor and HIV-1 Protease [AID162706, Type: Literature]Pol polyprotein [gi:75593047]
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25
[SID103179606]
IC50 0.00034In vitro inhibition of HIV protease, using a peptide hydrolysis assay [AID162043, Type: Literature]
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26
[SID103179606]
IC50 0.0004Inhibition of recombinant wild type HIV1 protease assessed as hydrolysis of fluorogenic substrate [AID458605, Type: Literature]
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27
[SID103179606]
IC50 0.0004Tested for inhibitory concentration against HIV-1 protease in experiment 2 [AID162381, Type: Literature]
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28
[SID103179606]
IC50 0.0004Inhibitory activity against HIV-1 Protease was determined [AID162203, Type: other]
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29
[SID103179606]
IC50 0.0004Binding activity against HIV-1 Protease [AID163468, Type: Literature]Pol polyprotein [gi:75593047]
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30
[SID103179606]
IC50 0.0004Binding activity against HIV-1 Protease [AID163469, Type: Literature]Pol polyprotein [gi:75593047]
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31
[SID103179606]
IC50 0.0004Inhibition of wild type HIV1 recombinant aspartic protease [AID320685, Type: Literature]Pol polyprotein [gi:75593047]
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32
[SID103179606]
Ki 0.00042Inhibition of wild type HIV1 protease by competitive binding [AID390727, Type: Literature]
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33
[SID103179606]
Ki 0.000452Inhibitory activity against P2 site in HIV protease. [AID163478, Type: other]
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34
[SID103179606]
IC50 0.0005Compound was evaluated for inhibitory activity against HIV-2 protease [AID160786, Type: Literature]
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35
[SID103179606]
IC50 0.0005Tested for inhibitory concentration against HIV-2 protease [AID160790, Type: Literature]Pol polyprotein [gi:82281241]
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36
[SID103179606]
Ki 0.00051Inhibition of HIV1 recombinant protease D30N/N88D mutant expressed in Escherichia coli by spectrophotometric assay [AID343015, Type: Literature]
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37
[SID103179606]
Kd 0.000577Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 7.4 [AID673196, Type: Literature]
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38
[SID103179606]
EC50 0.0006Inhibitory effects on HIV-1 induced syncytium formation in C8166 cells [AID44830, Type: Literature]
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39
[SID103179606]
Kd 0.000637Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 5.1 [AID673197, Type: Literature]
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40
[SID103179606]
IC50 0.001Inhibitory concentration required against HIV-1 protease [AID82775, Type: other]
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41
[SID103179606]
IC50 0.001In vitro inhibition of HIV-1 protease. [AID82765, Type: other]
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42
[SID103179606]
Ki 0.00103Inhibition of HIV1 Protease M2 variant by FRET based assay [AID297669, Type: Literature]
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43
[SID103179606]
Ki 0.0014Compound was evaluated for binding affinity against HIV protease [AID160294, Type: Literature]
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44
[SID103179606]
ED50 0.0015Concentration required for inhibitory activity against CEM cells in a whole cell assay [AID46359, Type: other]
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45
[SID103179606]
IC50 0.0017Inhibitory activity against human immunodeficiency virus protease (HIVP) using protease inhibition assay [AID82902, Type: other]
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46
[SID103179606]
EC50 0.0018Antiviral activity against wild type HIV1 NL4-3 in HEK293 cells after 48 hrs by replication-defective luciferase reporter gene-based phenotypic assay [AID374600, Type: Literature]
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47
[SID103179606]
IC50 0.0018Inhibitory activity against HIV-1 protease [AID162362, Type: other]Pol polyprotein [gi:75593047]
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48
[SID103179606]
IC50 0.0019Antiviral activity against HIV2 EHO isolate in human MT2 cells [AID269307, Type: Literature]
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49
[SID103179606]
EC50 0.0019Antiviral activity against wild type HIV1 [AID321685, Type: Literature]
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50
[SID103179606]
IC50 0.002Antiviral activity in HIV-infected CEM cells using whole cell assay [AID46386, Type: other]
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