CHEMBL1213202 (CID 44123621) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Unspecified(2)
 
 
Top Targets:
RYDR ITPR(6)
 
 
 
BioAssay Types:
Literature(6)
 
 
 
BioActivity Types:
Kd(3)
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104239371]
Kd 0.00052Displacement of [3H]IP3 from rat recombinant IP3R1 binding core residue (224-604) expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495146, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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2
[SID104239371]
Kd 0.0135Displacement of [3H]IP3 from rat recombinant N-terminal IP3R1 (1-604) expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495145, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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3
[SID104239371]
EC50 0.042Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular stores [AID495142, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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4
[SID104239371]
Kd 0.0436Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495143, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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5
[SID104239371]
 Agonist activity to rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular stores at maximum effective concentration [AID495157, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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6
[SID104239371]
 Ratio of EC50 to Kd for full-length rat recombinant DT40-IP3R1 expressed in chicken DT40 cells [AID495144, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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