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BioActivity Data for Compound Digitoxin (CID 441207)

BioActivity Outcomes:
Active(155)
 
 
Inactive(429)
 
 
Inconclusive(131)
 
 
Unspecified(217)
 
 
Top Targets:
7tm 4(57)
 
 
 
 
NR LBD PPAR(27)
 
 
 
NR LBD ER(18)
 
 
 
 
 
NR LBD AR(17)
 
 
 
 
 
NR LBD TR(12)
 
 
 
BioAssay Types:
Confirmatory(489)
 
 
 
 
 
Screening(192)
 
 
 
 
Literature(122)
 
 
 
 
 
Summary(52)
 
 
 
 
BioAssay Categories:
In vitro(137)
 
 
 
In vivo(43)
 
 
Biochemical(178)
 
 
 
 
Toxicity(88)
 
 
 
 
 
ADME(22)
 
 
 
 
Cell-based(176)
 
 
 
 
 
BioActivity Types:
Potency(360)
 
 
 
 
 
IC50(192)
 
 
 
 
 
EC50(8)
 
 
 
AC50(6)
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 784    Data Row: 932   Total Pages: 47   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556970]
Ki 0.0001Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digoxin as radioligand [AID127356, Type: Literature]
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2
[SID103556970]
Ki 0.0002Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digitoxin as radioligand [AID127355, Type: Literature]
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3
[SID103556970]
Kd 0.0006Kinetic parameter against Monoclonal antibody mAB-1B3 [AID127353, Type: Literature]
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4
[SID103556970]
IC50 0.0032Cytotoxicity against human TK10 cells after 48 hrs by SRB assay [AID399010, Type: Literature]
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5
[SID170464713]
Potency-Replicate_1 0.006qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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6
[SID103556970]
IC50 0.0064Cytotoxicity against human K562 cells by XTT assay [AID399014, Type: Literature]
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7
[SID144212586]
Potency-Replicate_1 0.0078qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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8
[SID103556970]
IC50 0.008Inhibition of [3H]- ouabain binding to digitalis receptor [AID56911, Type: Literature]
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9
[SID103556970]
IC50 0.008Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomes [AID56912, Type: Literature]Sodium/potassium-transporting ATPase subunit alpha-1 [gi:1703466]
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10
[SID144212586]
Potency-Replicate_1 0.0088qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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11
[SID103556970]
IC50 0.0102Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID399011, Type: Literature]
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12
[SID103556970]
GI50 0.0107Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay [AID553404, Type: Literature]
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13
[SID144212586]
Potency-Replicate_1 0.0109qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
View
14
[SID170464713]
IC50 0.011VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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15
[SID144212586]
Potency-Replicate_1 0.0123qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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16
[SID144212586]
Potency-Replicate_1 0.0139qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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17
[SID144212586]
Ratio Potency (uM) 0.0154511qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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18
[SID144212586]
Potency-Replicate_1 0.0156qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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19
[SID11533060]
Potency 0.0164Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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20
[SID144212586]
Potency-Replicate_1 0.0196qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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