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Digitoxin (CID 441207) - Compound BioActivity Data
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BioActivity Outcomes:
Active(135)
 
 
Inactive(413)
 
 
Inconclusive(120)
 
 
Unspecified(175)
 
 
Top Targets:
7TM GPCR Srsx(32)
 
 
 
 
NR LBD PPAR(27)
 
 
 
7TM GPCR Srx(27)
 
 
 
 
NR LBD ER(18)
 
 
 
 
 
NR LBD AR(17)
 
 
 
 
BioAssay Types:
Confirmatory(350)
 
 
 
 
 
Screening(184)
 
 
 
 
Literature(93)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(343)
 
 
 
 
 
IC50(186)
 
 
 
 
 
EC50(7)
 
 
 
Kd(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 704    Data Row: 843   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556970]
Ki 0.0001Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digoxin as radioligand [AID127356, Type: Literature]
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2
[SID103556970]
Ki 0.0002Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digitoxin as radioligand [AID127355, Type: Literature]
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3
[SID103556970]
Kd 0.0006Kinetic parameter against Monoclonal antibody mAB-1B3 [AID127353, Type: other]
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4
[SID103556970]
IC50 0.0032Cytotoxicity against human TK10 cells after 48 hrs by SRB assay [AID399010, Type: Literature]
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5
[SID170464713]
Potency-Replicate_1 0.006qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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6
[SID103556970]
IC50 0.0064Cytotoxicity against human K562 cells by XTT assay [AID399014, Type: Literature]
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7
[SID144212586]
Potency-Replicate_1 0.0078qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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8
[SID103556970]
IC50 0.008Inhibition of [3H]- ouabain binding to digitalis receptor [AID56911, Type: Literature]
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9
[SID103556970]
IC50 0.008Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomes [AID56912, Type: Literature]Sodium/potassium-transporting ATPase subunit alpha-1 [gi:1703466]
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10
[SID144212586]
Potency-Replicate_1 0.0088qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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11
[SID103556970]
IC50 0.0102Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID399011, Type: Literature]
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12
[SID103556970]
GI50 0.0107Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay [AID553404, Type: Literature]
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13
[SID144212586]
Potency-Replicate_1 0.0109qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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14
[SID144212586]
Potency-Replicate_1 0.0123qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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15
[SID144212586]
Potency-Replicate_1 0.0139qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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16
[SID144212586]
Ratio Potency (uM) 0.0154511qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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17
[SID144212586]
Potency-Replicate_1 0.0156qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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18
[SID11533060]
Potency 0.0164Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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19
[SID144212586]
Potency-Replicate_1 0.0196qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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20
[SID144212586]
Potency-Replicate_1 0.0196qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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21
[SID103556970]
IC50 0.02Antiproliferative activity against human MCF7 cells assessed as cell viability treated for 48 hrs followed by compound washout measured after 72 hrs by fluorometric CellTiter-Blue reagent assay [AID593490, Type: Literature]
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22
[SID144212586]
Potency-Replicate_1 0.022qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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23
[SID144212586]
Ratio Potency (uM) 0.0247039qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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24
[SID144212586]
Potency-Replicate_1 0.0308qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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25
[SID144212586]
Potency-Replicate_1 0.0311qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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26
[SID170464713]
Potency-Replicate_1 0.0335qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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27
[SID103556970]
IC50 0.0335Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay [AID399012, Type: Literature]
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28
[SID144205212]
Potency-Replicate_1 0.0338qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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29
[SID144205212]
Ratio Potency (uM) 0.0459192qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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30
[SID144205212]
Potency-Replicate_1 0.0473qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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31
[SID144205212]
Potency-Replicate_1 0.0531qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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32
[SID26754429]
Potency 0.0562qHTS assay for cell viability of HEK293 cells [AID743288, Type: confirmatory]
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33
[SID11533060]
Potency 0.058qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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34
[SID11533060]
Potency 0.0651A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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35
[SID170464713]
Potency-Replicate_1 0.0841qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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36
[SID170464713]
Potency-Replicate_1 0.0849qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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37
[SID144212586]
Potency-Replicate_1 0.0877qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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38
[SID144205212]
Potency 0.0891qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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39
[SID11533060]
Potency 0.0891qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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40
[SID144205212]
Potency-Replicate_1 0.0952qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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41
[SID144212586]
Potency-Replicate_1 0.0975qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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42
[SID144212586]
Potency-Replicate_1 0.0983qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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43
[SID103556970]
IC50 0.1Cytotoxicity against human colon cancer cells after 72 hrs by FMCA method [AID471518, Type: Literature]
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44
[SID170464713]
Potency-Replicate_1 0.1059qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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45
[SID170464713]
Potency-Replicate_1 0.1188qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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46
[SID144205212]
Potency-Replicate_1 0.1188qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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47
[SID144212586]
Potency-Replicate_1 0.1238qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID11533060]
Potency 0.1458qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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49
[SID11533060]
Potency 0.1458qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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50
[SID144212586]
Ratio Potency (uM) 0.154511qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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