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Digitoxin (CID 441207) - Compound BioActivity Data
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BioActivity Outcomes:
Active(133)
 
 
Inactive(416)
 
 
Inconclusive(120)
 
 
Unspecified(213)
 
 
Top Targets:
7TM GPCR Srsx(32)
 
 
 
 
NR LBD PPAR(27)
 
 
 
7TM GPCR Srx(26)
 
 
 
 
NR LBD ER(18)
 
 
 
 
 
NR LBD AR(17)
 
 
 
 
 
BioAssay Types:
Confirmatory(467)
 
 
 
 
 
Screening(184)
 
 
 
 
Literature(106)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(344)
 
 
 
 
 
IC50(186)
 
 
 
 
 
EC50(7)
 
 
 
Kd(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 743    Data Row: 882   Total Pages: 45   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556970]
Ki 0.0001Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digoxin as radioligand [AID127356, Type: Literature]
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2
[SID103556970]
Ki 0.0002Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digitoxin as radioligand [AID127355, Type: Literature]
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3
[SID103556970]
Kd 0.0006Kinetic parameter against Monoclonal antibody mAB-1B3 [AID127353, Type: Literature]
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4
[SID103556970]
IC50 0.0032Cytotoxicity against human TK10 cells after 48 hrs by SRB assay [AID399010, Type: Literature]
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5
[SID170464713]
Potency-Replicate_1 0.006qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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6
[SID103556970]
IC50 0.0064Cytotoxicity against human K562 cells by XTT assay [AID399014, Type: Literature]
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7
[SID144212586]
Potency-Replicate_1 0.0078qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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8
[SID103556970]
IC50 0.008Inhibition of [3H]- ouabain binding to digitalis receptor [AID56911, Type: Literature]
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9
[SID103556970]
IC50 0.008Inhibition of [3H]ouabain binding to Digitalis receptor in dog heart microsomes [AID56912, Type: Literature]Sodium/potassium-transporting ATPase subunit alpha-1 [gi:1703466]
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10
[SID144212586]
Potency-Replicate_1 0.0088qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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11
[SID103556970]
IC50 0.0102Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID399011, Type: Literature]
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12
[SID103556970]
GI50 0.0107Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay [AID553404, Type: Literature]
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13
[SID144212586]
Potency-Replicate_1 0.0109qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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14
[SID144212586]
Potency-Replicate_1 0.0123qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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15
[SID144212586]
Potency-Replicate_1 0.0139qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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16
[SID144212586]
Ratio Potency (uM) 0.0154511qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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17
[SID144212586]
Potency-Replicate_1 0.0156qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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18
[SID11533060]
Potency 0.0164Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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19
[SID144212586]
Potency-Replicate_1 0.0196qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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20
[SID144212586]
Potency-Replicate_1 0.0196qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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