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Strychnine (CID 441071) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(103)
 
 
Inconclusive(9)
 
 
Unspecified(164)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(17)
 
 
 
NR LBD ER(11)
 
 
 
 
NR LBD AR(10)
 
 
 
p450(10)
 
 
 
BioAssay Types:
Confirmatory(197)
 
 
 
 
 
Literature(38)
 
 
 
 
Summary(15)
 
 
Screening(2)
 
 
BioActivity Types:
IC50(127)
 
 
 
Potency(94)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 274    Data Row: 282   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103515892]
IC50 0.0083DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: confirmatory]
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2
[SID103515892]
IC50 0.014Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord [AID270051, Type: Literature]
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3
[SID103515892]
IC50 0.014Displacement of [3H]strychnine from glycine receptor in rat spinal cord synaptosomal membranes [AID286349, Type: Literature]
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4
[SID103515892]
IC50 0.016Inhibition of rat glycine receptor [AID566259, Type: Literature]
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5
[SID103515892]
IC50 21Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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6
[SID48416559]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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7
[SID103515892]
IC50 20GRAC: human Glycine receptor subunit alpha-1 selective antagonist [AID540530, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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8
[SID103515892]
IC50 40Cytotoxicity against human SW480 cells after 48 hrs by MTT assay [AID697151, Type: Literature]
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9
[SID103515892]
IC50 40Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay [AID697152, Type: Literature]
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10
[SID103515892]
IC50 40Cytotoxicity against human A549 cells after 48 hrs by MTT assay [AID697153, Type: Literature]
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11
[SID103515892]
IC50 40Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay [AID697154, Type: Literature]
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12
[SID103515892]
IC50 40Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID697155, Type: Literature]
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13
[SID103515892]
IC50 190Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes [AID241212, Type: Literature]
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14
[SID103515892]
Anticonvulsant activity in po dosed mouse assessed as inhibition of MES-induced tonic seizures [AID496866, Type: Literature]
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15
[SID103515892]
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM [AID205268, Type: Literature]
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16
[SID103515892]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: confirmatory]Mitogen-activated protein kinase 14 [gi:2499600]
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17
[SID103515892]
IC50 DRUGMATRIX: Bradykinin B2 radioligand binding (ligand: [3H] Bradykinin) [AID625213, Type: confirmatory]B2 bradykinin receptor [gi:2506481]
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18
[SID103515892]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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19
[SID103515892]
IC50 DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) [AID625173, Type: confirmatory]Angiotensin-converting enzyme [gi:2822103]
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20
[SID103515892]
IC50 DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: confirmatory]Mu-type opioid receptor [gi:2851402]
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