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BioActivity Data for Compound Strychnine (CID 441071)

BioActivity Outcomes:
Active(6)
 
 
Inactive(103)
 
 
Inconclusive(9)
 
 
Unspecified(166)
 
 
Top Targets:
7tm 4(32)
 
 
 
NR LBD ER(11)
 
 
 
 
p450(10)
 
 
 
NR LBD AR(10)
 
 
 
NR LBD GR(7)
 
 
 
 
BioAssay Types:
Confirmatory(197)
 
 
 
 
 
Literature(40)
 
 
 
 
Summary(15)
 
 
Screening(2)
 
 
BioAssay Categories:
In vitro(134)
 
 
 
Biochemical(155)
 
 
 
Toxicity(22)
 
 
 
 
ADME(5)
 
 
 
Cell-based(92)
 
 
 
BioActivity Types:
IC50(127)
 
 
 
Potency(94)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 276    Data Row: 284   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103515892]
IC50 0.0083DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: confirmatory]
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2
[SID103515892]
IC50 0.014Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord [AID270051, Type: Literature]
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3
[SID103515892]
IC50 0.014Displacement of [3H]strychnine from glycine receptor in rat spinal cord synaptosomal membranes [AID286349, Type: Literature]
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4
[SID103515892]
IC50 0.016Inhibition of rat glycine receptor [AID566259, Type: Literature]
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5
[SID103515892]
IC50 21Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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6
[SID48416559]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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7
[SID103515892]
IC50 20GRAC: human Glycine receptor subunit alpha-1 selective antagonist [AID540530, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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8
[SID103515892]
IC50 40Cytotoxicity against human SW480 cells after 48 hrs by MTT assay [AID697151, Type: Literature]
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9
[SID103515892]
IC50 40Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay [AID697152, Type: Literature]
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10
[SID103515892]
IC50 40Cytotoxicity against human A549 cells after 48 hrs by MTT assay [AID697153, Type: Literature]
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11
[SID103515892]
IC50 40Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay [AID697154, Type: Literature]
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12
[SID103515892]
IC50 40Cytotoxicity against human HL60 cells after 48 hrs by MTT assay [AID697155, Type: Literature]
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13
[SID103515892]
IC50 190Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes [AID241212, Type: Literature]
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14
[SID103515892]
DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) [AID625214, Type: other]Calcitonin receptor [gi:550544247]
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15
[SID103515892]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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16
[SID103515892]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: confirmatory]Melanocortin receptor 3 [gi:395398606]
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17
[SID103515892]
IC50 DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) [AID625167, Type: confirmatory]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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18
[SID103515892]
IC50 DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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19
[SID103515892]
DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) [AID625179, Type: other]Protein kinase C alpha type [gi:317373571]
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20
[SID103515892]
IC50 DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: confirmatory]Kappa-type opioid receptor [gi:116242691]
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