Arbutin (CID 440936) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(250)
 
 
Inconclusive(4)
 
 
Unspecified(86)
 
 
Top Targets:
Tyrosinase(31)
 
 
 
 
 
7TM GPCR Srx(9)
 
 
7TM GPCR Srsx(5)
 
 
Nuc rec co-ac..(3)
 
 
BRLZ(3)
 
 
BioAssay Types:
Screening(179)
 
 
 
Literature(96)
 
 
 
 
 
Confirmatory(60)
 
 
 
 
BioActivity Types:
Potency(54)
 
 
 
 
IC50(37)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 342    Data Row: 346   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103534069]
IC50 2.2Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation [AID422532, Type: Literature]
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2
[SID103534069]
IC50 30.26Inhibition of tyrosinase in mouse Melan-a cells by ELISA [AID457084, Type: Literature]Tyrosinase [gi:152060989]
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3
[SID103534069]
IC50 30.26Inhibition of tyrosinase in Melan-a cells [AID309189, Type: Literature]Tyrosinase [gi:401235]
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4
[SID103534069]
 Inhibition of tyrosinase in alpha-MSH-stimulated mouse B16F10 cells assessed as inhibition of L-DOPA oxidation at 40 to 120 uM after 72 hrs by spectrophotometry [AID634633, Type: Literature]Tyrosinase [gi:152060989]
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5
[SID93576640]
 Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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6
[SID103534069]
 Antimelanogenic activity in mouse B16F10 cells assessed as inhibition of alpha-MSH-induced melanin formation at 40 to 120 uM after 72 hrs by spectrophotometry [AID634634, Type: Literature]
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7
[SID103534069]
IC50 98.05Inhibition of melanin formation in mouse Melan-a cells after 5 days by ELISA [AID457085, Type: Literature]
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8
[SID103534069]
IC50 99Inhibition of alpha-MSH-induced melanin synthesis in mouse B16 cells grown in a 5% CO2-95% air atmosphere after 3 days [AID592647, Type: Literature]
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9
[SID103534069]
IC50 103Inhibition of melanin synthesis in NHEM cells assessed as [14C]thiouracil incorporation after 72 hrs by liquid scintillation counting [AID421667, Type: Literature]
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10
[SID103534069]
IC50 116Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells after 72 hrs [AID450471, Type: Literature]
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11
[SID103534069]
IC50 118.05Inhibition of melanin formation in Melan-a cells after 5 days [AID309190, Type: Literature]
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12
[SID103534069]
IC50 120Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 3 days [AID590443, Type: Literature]
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13
[SID103534069]
IC50 174Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs [AID462338, Type: Literature]
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14
[SID103534069]
IC50 180Antimelanogenic activity in mouse B16 cells assessed as inhibition of alpha-MSH-induced melanogenesis [AID494971, Type: Literature]
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15
[SID103534069]
IC50 180Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs [AID460789, Type: Literature]
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16
[SID103534069]
IC50 180Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs [AID457968, Type: Literature]
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17
[SID103534069]
IC50 180Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 3 days [AID598529, Type: Literature]
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18
[SID103534069]
IC50 180Antimelanogenic activity at alpha-MSH-stimulated mouse melanoma B16 cells after 3 days by spectrophotometry [AID639982, Type: Literature]
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19
[SID103534069]
IC50 201.2Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry [AID590195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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20
[SID103534069]
IC50 210Inhibition of mushroom tyrosinase after 30 mins [AID510195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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21
[SID103534069]
IC50 230Inhibition of tyrosinase [AID377689, Type: Literature]
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22
[SID103534069]
IC50 1000Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability after 68 hrs by WST8 assay [AID450477, Type: Literature]
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23
[SID103534069]
IC50 1000Inhibition of mushroom tyrosinase [AID450483, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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24
[SID103534069]
IC50 1500Cytotoxicity againt Melan-a cells by MTT assay [AID309191, Type: Literature]
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25
[SID103534069]
IC50 1550Inhibition of tyrosinase activity in alpha-MSH-stimulated mouse B16 cells using L-tyrosine as substrate [AID592651, Type: Literature]Tyrosinase [gi:152060989]
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26
[SID103534069]
ID50 6200Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA [AID332456, Type: other]Polyphenol oxidase 2 [gi:6686057]
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27
[SID103534069]
IC50 7300Inhibition of mushroom tyrosinase [AID444073, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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28
[SID103534069]
IC50 7300Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation [AID411681, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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29
[SID103534069]
IC50 10400Inhibition of mushroom tyrosinase [AID327624, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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30
[SID103534069]
IC50 10400Inhibition of mushroom tyrosinase [AID372668, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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31
[SID103534069]
IC50 10400Inhibition of diphenolase activity of mushroom tyrosinase preincubated with compound for 10 mins before addition of L-DOPA as substrate by spectrophotometric analysis [AID589733, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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32
[SID103534069]
IC50 17000Inhibition of tyrosinase [AID497310, Type: Literature]
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33
[SID103534069]
IC50 24000Inhibition of mushroom tyrosinase [AID336442, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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34
[SID103534069]
IC50 24000Inhibition of mushroom tyrosinase by spectrophotometry [AID400520, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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35
[SID103534069]
IC50 32000Inhibitory activity against mushroom tyrosinase [AID215967, Type: Literature]
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36
[SID103534069]
 Inhibition of alpha-MSH-induced melanin production in mouse B16 cells at 10 uM after 72 hrs [AID460788, Type: Literature]
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37
[SID103534069]
 Inhibition of melanin production in mouse B16 cells at 100 uM after 48 hrs by spectrophotometry relative to control [AID424782, Type: Literature]
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38
[SID103534069]
 Inhibition of tyrosinase at 5 uM [AID396462, Type: Literature]
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39
[SID103534069]
 Inhibition of melanogenesis in human dermal fibroblasts at 5 uM [AID396463, Type: Literature]
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40
[SID103534069]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 300 uM after 72 hrs [AID462331, Type: Literature]
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41
[SID103534069]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 100 uM after 72 hrs [AID462332, Type: Literature]
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42
[SID103534069]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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43
[SID103534069]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 10 uM after 72 hrs [AID462334, Type: Literature]
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44
[SID103534069]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 1000 uM after 72 hrs [AID462337, Type: Literature]
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45
[SID103534069]
 Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 300 uM after 72 hrs [AID450489, Type: Literature]
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46
[SID103534069]
 Inhibition of melanogenesis in theophyline-stimulated mouse B16-4A5 cells at 1000 uM after 72 hrs [AID450490, Type: Literature]
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47
[SID103534069]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 300 uM after 68 hrs by WST8 assay [AID450491, Type: Literature]
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48
[SID103534069]
 Inhibition of theophyline-stimulated mouse B16-4A5 cell proliferation assessed as cell viability at 1000 uM after 68 hrs by WST8 assay [AID450492, Type: Literature]
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49
[SID103534069]
 Inhibition of melanin production in mouse B16F10 cells at 500 uM after 2 days [AID548091, Type: Literature]
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50
[SID103534069]
 Cytotoxicity against mouse B16F10 cells assessed as cell viability after 24 hrs by MTT assay [AID548093, Type: Literature]
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