Captopril (CID 44093) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(85)
 
 
Inactive(1131)
 
 
Inconclusive(71)
 
 
Unspecified(1745)
 
 
Top Targets:
7TM GPCR Srx(36)
 
 
 
 
7TM GPCR Srsx(21)
 
 
 
Tryp SPc(15)
 
 
 
alkPPc(14)
 
 
p450(13)
 
 
 
BioAssay Types:
Screening(564)
 
 
 
 
Confirmatory(487)
 
 
 
 
 
Literature(372)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(395)
 
 
 
 
 
IC50(234)
 
 
 
 
 
Ki(12)
 
 
 
EC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2771    Data Row: 3032   Total Pages: 61   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103581295]
IC50 2.7e-08In vitro inhibitory activity against Angiotensin I converting enzyme [AID37667, Type: Literature]Angiotensin-converting enzyme [gi:2822103]
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2
[SID103581295]
IC50 0.00012Inhibition of human recombinant ACE by fluorimetry [AID433785, Type: Literature]Angiotensin-converting enzyme [gi:113045]
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3
[SID103581295]
IC50 0.00063Inhibition of human ACE [AID340316, Type: Literature]Angiotensin-converting enzyme [gi:113045]
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4
[SID103581295]
Ki 0.0017Inhibitory activity against rabbit lung angiotensin-1 converting enzyme [AID37801, Type: Literature]
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5
[SID103581295]
Ki 0.0017Antihypertensive activity against human renin [AID198995, Type: Literature]Renin [gi:132326]
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6
[SID103581295]
Ki 0.002Inbition of Angiotensin I converting enzyme (ACE) [AID38253, Type: Literature]
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7
[SID103581295]
IC50 0.0023In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base. (reported from ref. 1b) [AID38438, Type: other]
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8
[SID103581295]
IC50 0.003In vitro inhibitory activity against rat serum angiotensin I converting enzyme using hippuryl-glycyl-glycine as substrate [AID39615, Type: Literature]
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9
[SID103581295]
IC50 0.0036In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base [AID38437, Type: other]
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10
[SID103581295]
IC50 0.005Inhibition of ACE by fluorometric assay [AID338980, Type: other]
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11
[SID103581295]
IC50 0.0077Inhibition of ACE [AID319059, Type: Literature]
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12
[SID103581295]
IC50 0.009Inhibition of guinea pig serum Angiotensin I converting enzyme [AID39752, Type: Literature]
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13
[SID103581295]
IC50 0.009Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50% [AID39754, Type: Literature]
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14
[SID103581295]
IC50 0.01In vitro inhibitory concentration against angiotensin-converting enzyme [AID38458, Type: other]
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15
[SID103581295]
IC50 0.01Evaluation of in vitro inhibitory activity against Angiotensin I converting enzyme [AID37656, Type: Literature]
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16
[SID103581295]
IC50 0.011In vitro inhibitory activity against Angiotensin I converting enzyme [AID38092, Type: Literature]
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17
[SID103581295]
IC50 0.012Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. [AID38089, Type: Literature]
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18
[SID103581295]
IC50 0.012Concentration required for 50% inhibition of Angiotensin I converting enzyme [AID39755, Type: Literature]
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19
[SID103581295]
IC50 0.0129Compound tested in vitro for inhibition of Angiotensin I converting enzyme [AID38853, Type: Literature]
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20
[SID103581295]
IC50 0.013Compound was tested for its inhibitory activity against Angiotensin I converting enzyme [AID37652, Type: Literature]
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21
[SID103581295]
IC50 0.013Inhibition of guinea pig angiotensin I converting enzyme [AID39758, Type: Literature]
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22
[SID103581295]
IC50 0.015In vitro inhibitory activity against Angiotensin I converting enzyme [AID38860, Type: Literature]
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23
[SID103581295]
IC50 0.015In vitro inhibition of Angiotensin I converting enzyme [AID37659, Type: Literature]
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24
[SID103581295]
IC50 0.015In vitro inhibition of angiotensin I converting enzyme (ACE) [AID37660, Type: Literature]
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25
[SID103581295]
IC50 0.015Ability to inhibit Angiotensin I converting enzyme was determined [AID37928, Type: Literature]
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26
[SID103581295]
IC50 0.015Inhibition of Angiotensin I converting enzyme in rat [AID38091, Type: Literature]Angiotensin-converting enzyme [gi:1351843]
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27
[SID103581295]
IC50 0.017In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 [AID37669, Type: Literature]
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28
[SID103581295]
IC50 0.017In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung [AID37640, Type: Literature]
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29
[SID103581295]
IC50 0.018In vitro inhibition of Angiotensin I converting enzyme in rabbit lung [AID37931, Type: Literature]
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30
[SID103581295]
IC50 0.02Inhibition of Angiotensin I converting enzyme [AID38850, Type: Literature]
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31
[SID103581295]
IC50 0.02In vitro inhibitory activity against Angiotensin I converting enzyme [AID38852, Type: Literature]
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32
[SID103581295]
IC50 0.02Inhibitory concentration against angiotensin converting enzyme (ACE) [AID38441, Type: other]
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33
[SID103581295]
IC50 0.02In vitro inhibitory activity against Angiotensin I converting enzyme in rabbit lung, using hippuryl-histidyl-leucine as substrate [AID37647, Type: Literature]
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34
[SID103581295]
IC50 0.022In vitro 50% inhibition of Angiotensin I converting enzyme [AID37657, Type: Literature]
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35
[SID103581295]
IC50 0.02291Inhibitory activity against angiotensin converting enzyme (ACE) [AID39018, Type: Literature]
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36
[SID103581295]
IC50 0.023Inhibitory activity against angiotensin I converting enzyme (ACE) [AID39767, Type: Literature]
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37
[SID103581295]
IC50 0.023Inhibition of ACE [AID362193, Type: Literature]
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38
[SID103581295]
IC50 0.023In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate [AID37646, Type: Literature]
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39
[SID103581295]
IC50 0.023In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrate [AID37662, Type: other]
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40
[SID103581295]
IC50 0.023In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme [AID37668, Type: Literature]
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41
[SID103581295]
IC50 0.023In vitro inhibition against angiotensin converting enzyme (ACE) [AID38457, Type: other]
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42
[SID103581295]
IC50 0.023In vitro inhibitory activity against angiotensin I converting enzyme of rats. [AID37962, Type: Literature]
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43
[SID103581295]
IC50 0.023In vivo inhibitory activity against Angiotensin I converting enzyme was evaluated in renal hypertensive rats [AID37963, Type: Literature]
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44
[SID103581295]
IC50 0.023Inhibitory concentration against angiotensin I converting enzyme [AID254756, Type: Literature]Angiotensin-converting enzyme [gi:113045]
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45
[SID103581295]
IC50 0.025In vitro inhibition of Angiotensin I converting enzyme in Hog plasma [AID39761, Type: Literature]
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46
[SID103581295]
IC50 0.03Compound was tested for inhibitory activity against Angiotensin I converting enzyme [AID38854, Type: other]
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47
[SID103581295]
Ki 0.048Inhibitory activity against thrombin [AID211913, Type: Literature]
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48
[SID103581295]
IC50 0.07Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes [AID99743, Type: other]Leukotriene A-4 hydrolase [gi:126353]
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49
[SID103581295]
Ki 0.0715Enzyme kinetic inhibition constant against tripeptide, Hip-His-Leu as substrate [AID228126, Type: Literature]
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50
[SID103581295]
IC50 0.07943Inhibition of angiotensin I converting enzyme in silico [AID38849, Type: Literature]
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