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BioActivity Data for Compound Cortodoxone (CID 440707)

BioActivity Outcomes:
Active(13)
 
 
Inactive(1194)
 
 
Inconclusive(61)
 
 
Unspecified(36)
 
 
Top Targets:
7tm 4(57)
 
 
 
Tryp SPc(15)
 
 
NR LBD PPAR(14)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(623)
 
 
 
 
Confirmatory(503)
 
 
 
 
 
Literature(123)
 
 
 
 
 
Summary(30)
 
 
 
 
BioAssay Categories:
In vitro(3)
 
 
 
In vivo(2)
 
 
Biochemical(163)
 
 
 
 
Toxicity(19)
 
 
 
ADME(2)
 
 
Cell-based(160)
 
 
 
Organism-base..(14)
 
 
BioActivity Types:
Potency(446)
 
 
 
 
 
IC50(48)
 
 
 
EC50(11)
 
 
AC50(6)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1059    Data Row: 1304   Total Pages: 66   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204418]
Potency-Replicate_1 0.0038qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID144204418]
Ratio Potency (uM) 0.00393847qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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3
[SID103556911]
Kd 0.03631Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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4
[SID144204418]
Potency-Replicate_1 0.3378qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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5
[SID144204418]
Potency-Replicate_1 4.2163qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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6
[SID103556911]
IC50 10Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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7
[SID103556911]
IC50 10Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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8
[SID144204418]
Ratio Potency (uM) 10.4357qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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9
[SID144204418]
Potency-Replicate_1 11.9856qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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10
[SID855521]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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11
[SID855521]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
12
[SID144204418]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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13
[SID855521]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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14
[SID50103892]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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15
[SID103556911]
TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing LLC-PK1 cells [AID679242, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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16
[SID50103892]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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17
[SID103556911]
Inhibition of mouse constitutive androstane receptor (mCAR) activity at 10 uM was determined as percent remaining activity [AID50906, Type: Literature]
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18
[SID103556911]
Diffusion constant for permeability of stratum corneum [AID23943, Type: Literature]
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19
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 24 hr [AID74373, Type: Literature]
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20
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 4 hr [AID74374, Type: Literature]
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