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Cortodoxone (CID 440707) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(1141)
 
 
Inconclusive(66)
 
 
Unspecified(36)
 
 
Top Targets:
7TM GPCR Srx(32)
 
 
 
7TM GPCR Srsx(24)
 
 
Tryp SPc(15)
 
 
NR LBD PPAR(14)
 
 
 
alkPPc(14)
 
 
BioAssay Types:
Screening(612)
 
 
 
 
Confirmatory(482)
 
 
 
 
 
Literature(111)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(427)
 
 
 
 
 
IC50(46)
 
 
 
EC50(11)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1026    Data Row: 1256   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204418]
Potency-Replicate_1 0.0038qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID144204418]
Ratio Potency (uM) 0.00393847qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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3
[SID103556911]
Kd 0.03631Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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4
[SID144204418]
Potency-Replicate_1 0.3378qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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5
[SID144204418]
Potency-Replicate_1 4.2163qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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6
[SID103556911]
IC50 10Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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7
[SID103556911]
IC50 10Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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8
[SID144204418]
Ratio Potency (uM) 10.4357qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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9
[SID855521]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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10
[SID855521]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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11
[SID144204418]
Potency-Replicate_1 26.6032qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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12
[SID144204418]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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13
[SID855521]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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14
[SID50103892]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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15
[SID103556911]
TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing LLC-PK1 cells [AID679242, Type: other]Multidrug resistance protein 1 [gi:238054374]
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16
[SID103556911]
Diffusion constant for permeability of stratum corneum [AID23943, Type: Literature]
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17
[SID103556911]
Relative binding affinity for androgen receptor of prostate of rat at 2 hr [AID39320, Type: Literature]
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18
[SID103556911]
Inhibition of mouse constitutive androstane receptor (mCAR) activity at 10 uM was determined as percent remaining activity [AID50906, Type: Literature]
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19
[SID103556911]
In silico binding affinity to human corticosteriod binding globulin [AID51048, Type: Literature]
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20
[SID103556911]
Binding affinity against corticosteroid-binding globulin [AID51049, Type: Literature]
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21
[SID103556911]
In silico binding affinity to corticosteroid binding globulin (CBG) [AID51052, Type: Literature]
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22
[SID103556911]
Binding affinity for corticosteroid binding globulin is expressed as log(1/k) [AID51054, Type: Literature]
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23
[SID103556911]
Binding affinity to human CBG receptor (corticosteroid-binding globulins) [AID51055, Type: Literature]
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24
[SID103556911]
Binding affinity towards corticosteroid-binding globulin (CBG) [AID51058, Type: Literature]
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25
[SID103556911]
Binding affinity to corticosteroid binding globulin [AID51059, Type: Literature]
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26
[SID103556911]
In silico steroid binding affinity to transport protein corticosteroid binding globulin [AID51062, Type: Literature]
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27
[SID103556911]
Binding affinity to the corticosteroid-binding globulin (CBG) receptor. [AID53796, Type: Literature]
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28
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 24 hr [AID74373, Type: Literature]
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29
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from hepatoma tissue cells at 4 hr [AID74374, Type: Literature]
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30
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from liver at 24 hr [AID74375, Type: Literature]
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31
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from liver at 4 hr [AID74376, Type: Literature]
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32
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 24 hr [AID74377, Type: Literature]
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33
[SID103556911]
Relative binding affinity to glucocorticoid receptor on cytosol from thymus at 4 hr [AID74378, Type: Literature]
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34
[SID103556911]
Relative binding affinity for mineralocorticoid receptor of rat kidney at 24 hr [AID126435, Type: Literature]
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35
[SID103556911]
Relative binding affinity for progestin receptor of uterus of rabbit at 24 hr [AID162613, Type: Literature]
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36
[SID103556911]
Binding affinity against testosterone-binding globulin (TeBG) [AID212737, Type: Literature]
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37
[SID103556911]
Binding affinity towards testosterone binding globulin is expressed as log(1/k). [AID212919, Type: Literature]
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38
[SID103556911]
Binding affinity against transport protein testosterone binding globulin. [AID212920, Type: Literature]
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39
[SID103556911]
Binding affinity towards human testosterone binding globulin. [AID212931, Type: Literature]
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40
[SID103556911]
Glucocorticoid induced Tyrosine Aminotransferase activity relative to Dexamethasone [AID213396, Type: Literature]
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41
[SID103556911]
Binding affinity towards human corticosteroid binding globulin. [AID220020, Type: Literature]
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42
[SID103556911]
Binding affinity towards human testosterone binding globulin. [AID228061, Type: Literature]
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43
[SID103556911]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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44
[SID103556911]
Permeability coefficient in human skin [AID311367, Type: Literature]
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45
[SID50103892]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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46
[SID56320663]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID855521]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_CIT2 [AID1870, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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48
[SID103556911]
Inhibition of human 17beta-HSD7 expressed in HEK293 cells assessed as inhibition of reduction of [14C]estrone into [14C]estradiol at 0.3 uM after 7 hrs [AID468984, Type: Literature]3-keto-steroid reductase [gi:8134404]
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49
[SID103556911]
Inhibition of human 17beta-HSD7 expressed in HEK293 cells assessed as inhibition of reduction of [14C]estrone into [14C]estradiol at 3 uM after 7 hrs [AID468985, Type: Literature]3-keto-steroid reductase [gi:8134404]
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50
[SID56320663]
Potency 0.0046A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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