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BioActivity Data for Compound Pentostatin (CID 439693)

BioActivity Outcomes:
Active(14)
 
 
Inactive(71)
 
 
Inconclusive(2)
 
 
Unspecified(49)
 
 
Top Targets:
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
7tm 4(2)
 
 
BioAssay Types:
Literature(60)
 
 
 
 
Confirmatory(57)
 
 
 
Summary(15)
 
 
 
Screening(2)
 
 
BioAssay Categories:
In vitro(1)
 
 
In vivo(1)
 
 
Biochemical(12)
 
 
 
 
Toxicity(27)
 
 
 
 
ADME(22)
 
 
Cell-based(2)
 
 
BioActivity Types:
Potency(67)
 
 
 
Ki(8)
 
 
AC50(3)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 136   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103589743]
Ki 1e-07Inhibition of adenosine deaminase [AID717435, Type: Literature]
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2
[SID103589743]
Ki 1e-06Compound was tested for the inhibition of adenosine deaminase from calf intestine; Range of 0.01-0.001 nM [AID33670, Type: Literature]
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3
[SID103589743]
Ki 1e-06Binding affinity towards calf spleen adenosine deaminase was determined [AID33661, Type: Literature]
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4
[SID103589743]
Ki 2.5e-06The compound was tested in vitro for inhibition of human erythrocytic adenosine deaminase. [AID33969, Type: Literature]
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5
[SID103589743]
Ki 2.5e-06Binding affinity (Ki) at calf intestinal adenosine deaminase. [AID33656, Type: Literature]
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6
[SID103589743]
Ki 1e-05Binding affinity against Adenosine deaminase from calf intestinal mucosa was determined [AID33660, Type: Literature]
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7
[SID103589743]
Ki 3.3e-05Inhibition constant against human adenosine deaminase was determined [AID33849, Type: Literature]
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8
[SID103589743]
Ki 0.0001Compound was evaluated for the inhibition of adenosine deaminase [AID33846, Type: Literature]
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9
[SID103589743]
IC50 0.25Compound was evaluated for the cytotoxicity against L1210 cells in presence of coformycin [AID98361, Type: Literature]
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10
[SID103589743]
IC50 1.9Compound was evaluated for the cytotoxicity against L1210 cells in absence of coformycin [AID98360, Type: Literature]
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11
[SID103589743]
Adenosine deaminase inhibitor [AID742835, Type: other]Adenosine deaminase [gi:113339]
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12
[SID144206967]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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13
[SID144206967]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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14
[SID48416395]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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15
[SID103589743]
Pharmacokinetic property (AUC) was determined after ip administration of 32 mg/kg in mice [AID8593, Type: Literature]
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16
[SID103589743]
Pharmacokinetic property (C(max)) was determined after ip administration of 32 mg/kg in mice [AID9760, Type: Literature]
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17
[SID103589743]
Binding affinity against calf intestine adenosine deaminase enzyme; 10E-11 to 10e-12 M [AID33658, Type: Literature]
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18
[SID103589743]
Relative enzyme affinity for adenosine deaminase was determined; No data [AID33829, Type: Literature]
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19
[SID103589743]
Proposed mechanism(s) of liver damage. [column 'MEC' in source] [AID1079949, Type: Literature]
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20
[SID103589743]
Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] [AID1079948, Type: Literature]
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