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Tosylphenylalanyl Chloromethyl Ketone (CID 439647) - Compound BioActivity Data
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BioActivity Outcomes:
Active(130)
 
 
Inactive(848)
 
 
Inconclusive(91)
 
 
Unspecified(15)
 
 
Top Targets:
7TM GPCR Srx(30)
 
 
 
7TM GPCR Srsx(19)
 
 
 
Bcl-2 like(12)
 
 
 
Tryp SPc(11)
 
 
 
 
ANK(10)
 
 
 
 
BioAssay Types:
Screening(518)
 
 
 
 
Confirmatory(473)
 
 
 
 
 
Literature(57)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(378)
 
 
 
 
 
IC50(66)
 
 
 
 
 
EC50(9)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 881    Data Row: 1084   Total Pages: 55   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26753659]
Potency 0.3981qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID26753659]
Potency 0.4467Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1): Followup Confirmation and Counterscreen [AID493210, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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3
[SID50107082]
Potency 0.4467Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1): Followup Confirmation and Counterscreen [AID493210, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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4
[SID56423152]
IC50_Mean 0.64Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. [AID504672, Type: confirmatory]TPA: protein transporter TIM10 [Saccharomyces cerevisiae S288c] [gi:285809906]
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5
[SID11533046]
EC50_uM 0.712Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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6
[SID50107082]
Potency 0.7943qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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7
[SID11533046]
Potency 1qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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8
[SID56423152]
AC50_uM 1.47Luminescence Whole-Organism Dose Retest to Confirm Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID463204, Type: confirmatory]
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9
[SID11533046]
EC50_uM 1.863Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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10
[SID56423152]
IC50 1.868Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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11
[SID56423152]
IC50 1.868Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]perilipin-1 [Homo sapiens] [gi:223718203]
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12
[SID56423152]
IC50 1.901Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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13
[SID56423152]
IC50 1.901Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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14
[SID11533046]
AC50_uM 2.032Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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15
[SID56423152]
IC50_Mean 2.18Dose Response confirmation of uHTS small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID493002, Type: confirmatory]TPA: protein transporter TIM23 [Saccharomyces cerevisiae S288c] [gi:285814664]
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16
[SID56423152]
Potency 2.3109A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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17
[SID56423152]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID26753659]
Potency 2.8184Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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19
[SID11111883]
Potency 3.1623qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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20
[SID50107082]
Potency 3.1623qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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