taxifolin (CID 439533) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(20)
 
 
Inactive(488)
 
 
Inconclusive(15)
 
 
Unspecified(53)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(8)
 
 
NR LBD PPAR(6)
 
 
alkPPc(6)
 
 
 
BioAssay Types:
Screening(362)
 
 
 
 
Confirmatory(133)
 
 
 
 
 
Literature(48)
 
 
 
 
 
BioActivity Types:
Potency(108)
 
 
 
 
 
IC50(31)
 
 
 
 
 
EC50(9)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 570    Data Row: 576   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463005]
Potency 0.5623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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2
[SID26719897]
Potency 3.1623qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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3
[SID26719897]
Potency 3.1623qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID49681666]
IC50 5.9A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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5
[SID26719897]
Potency 10qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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6
[SID26719897]
Potency 10qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID26719897]
Potency 19.9526qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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8
[SID103168531]
IC50 24.2Antioxidant activity assessed as superoxide radical anion scavenging activity [AID380203, Type: Literature]
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9
[SID49681666]
IC50 31.96Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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10
[SID103168531]
IC50 35Inhibition of human Beta-secretase 1 [AID44249, Type: Literature]Beta-secretase 1 [gi:296434407]
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11
[SID103168531]
IC50 40.1Inhibition of reduced carboxymethylated kappa-casein fibril formation measured every 5 mins after 1000 mins by thioflavin T staining-based binding assay [AID456187, Type: Literature]
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12
[SID103168531]
EC50 45Anti-HIV activity in cell culture assay expressed as EC50 values. [AID81248, Type: other]
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13
[SID103168531]
IC50 45Anti-HIV activity in cell culture assay expressed as IC50 values. [AID81601, Type: other]
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14
[SID56463005]
Potency 79.4328qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID56463005]
Potency 79.4328qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID49681666]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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17
[SID49681666]
 uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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18
[SID26719897]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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19
[SID26719897]
 QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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20
[SID49681666]
 Single concentration confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID434971, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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21
[SID103168531]
 Antioxidant activity assessed as DPPH radical scavenging activity after 20 min [AID293297, Type: Literature]
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22
[SID103168531]
 Antioxidant activity assessed as inhibition of superoxide production by xanthine/xanthine oxidase method [AID293298, Type: Literature]
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23
[SID49681666]
 Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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24
[SID103168531]
EC50 10Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay [AID477845, Type: Literature]
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25
[SID103168531]
EC50 10Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay [AID477846, Type: Literature]
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26
[SID103168531]
EC50 10Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay [AID477847, Type: Literature]
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27
[SID103168531]
EC50 10Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay [AID477848, Type: Literature]
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28
[SID103168531]
EC50 10Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay [AID477849, Type: Literature]
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29
[SID103168531]
EC50 10Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay [AID477850, Type: Literature]
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30
[SID103168531]
EC50 10Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method [AID477851, Type: Literature]
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31
[SID103168531]
IC50 100Inhibitory activity against protein kinase C (PKC) [AID165132, Type: other]
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32
[SID103168531]
IC50 500In vitro inhibitory concentration against PC-3 cell line in MTT assay was determined after 3 days incubation [AID248692, Type: Literature]
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33
[SID103168531]
IC50 500In vitro inhibitory concentration against SKOV3 cell line in MTT assay was determined after 3 days incubation [AID248706, Type: Literature]
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34
[SID103168531]
IC50 500In vitro inhibitory concentration against U373MG cell line in MTT assay was determined after 3 days incubation [AID248718, Type: Literature]
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35
[SID103168531]
IC50 850.3Modulation of classical complement pathway system assessed as hemoglobin release by spectrophotometry [AID380219, Type: Literature]
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36
[SID103168531]
 Inhibition against HIV replication in cell culture at 20 ug/mL [AID81794, Type: other]
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37
[SID103168531]
 Inhibitory activity derived from Anastatica hierochuntica on D-Gal-induced cytotoxicity in primary cultured mouse hepatocytes at a concentration of 0 uM [AID140148, Type: Literature]
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38
[SID103168531]
 Inhibitory activity derived from Anastatica hierochuntica on D-Gal-induced cytotoxicity in primary cultured mouse hepatocytes at a concentration of 10 uM [AID140149, Type: Literature]
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39
[SID103168531]
 Inhibitory activity derived from Anastatica hierochuntica on D-Gal-induced cytotoxicity in primary cultured mouse hepatocytes at a concentration of 3 uM [AID140150, Type: Literature]
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40
[SID103168531]
 Inhibitory activity derived from Anastatica hierochuntica on D-Gal-induced cytotoxicity in primary cultured mouse hepatocytes at a concentration of 30 uM [AID140151, Type: Literature]
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41
[SID103168531]
 Inhibition of beta amyloid (1 to 42) fibril formation at 50 ug/mL by thioflavin T staining-based binding assay [AID456190, Type: Literature]
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42
[SID103168531]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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43
[SID103168531]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 10 uM after 72 hrs [AID462334, Type: Literature]
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44
[SID103168531]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 3 uM after 72 hrs [AID462335, Type: Literature]
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45
[SID103168531]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 1 uM after 72 hrs [AID462336, Type: Literature]
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46
[SID103168531]
 Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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47
[SID103168531]
 Cytotoxicity against human MT4 cells by MTT assay [AID380205, Type: Literature]
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48
[SID103168531]
 Selectivity index, ratio of CC50 for human MT4 cells to IC50 for HIV infected in human MT4 cells [AID380206, Type: Literature]
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49
[SID103168531]
 Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID380207, Type: Literature]
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50
[SID103168531]
 Antimicrobial activity against Candida albicans [AID380212, Type: Literature]
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