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taxifolin (CID 439533) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(577)
 
 
Inconclusive(17)
 
 
Unspecified(55)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(17)
 
 
Bcl-2 like(11)
 
 
G-alpha(7)
 
 
 
alkPPc(6)
 
 
 
BioAssay Types:
Screening(427)
 
 
 
 
Confirmatory(154)
 
 
 
 
 
Literature(60)
 
 
 
 
 
BioActivity Types:
Potency(128)
 
 
 
 
 
IC50(32)
 
 
 
 
 
EC50(9)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 610    Data Row: 670   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463005]
Potency 0.5623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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2
[SID26719897]
Potency 3.1623qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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3
[SID49681666]
IC50 5.9A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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4
[SID26719897]
Potency 10qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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5
[SID26719897]
Potency 19.9526qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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6
[SID103168531]
IC50 24.2Antioxidant activity assessed as superoxide radical anion scavenging activity [AID380203, Type: Literature]
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7
[SID49681666]
IC50 31.96Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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8
[SID103168531]
IC50 35Inhibition of human Beta-secretase 1 [AID44249, Type: Literature]Beta-secretase 1 [gi:296434407]
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9
[SID103168531]
IC50 40.1Inhibition of reduced carboxymethylated kappa-casein fibril formation measured every 5 mins after 1000 mins by thioflavin T staining-based binding assay [AID456187, Type: Literature]
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10
[SID103168531]
EC50 45Anti-HIV activity in cell culture assay expressed as EC50 values. [AID81248, Type: other]
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11
[SID103168531]
IC50 45Anti-HIV activity in cell culture assay expressed as IC50 values. [AID81601, Type: other]
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12
[SID56463005]
Potency 79.4328qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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13
[SID49681666]
Single concentration confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID434971, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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14
[SID49681666]
uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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15
[SID26719897]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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16
[SID49681666]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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17
[SID103168531]
Antioxidant activity assessed as DPPH radical scavenging activity after 20 min [AID293297, Type: Literature]
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18
[SID103168531]
IC50 Antioxidant activity assessed as inhibition of superoxide production by xanthine/xanthine oxidase method [AID293298, Type: Literature]
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19
[SID56463005]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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20
[SID56463005]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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21
[SID49681666]
Counterscreen for PME1 inhibitors: fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of lysophospholipase 2 (LYPLA2). [AID2177, Type: screening]lysophospholipase II [Homo sapiens] [gi:4581413]
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22
[SID103168531]
EC50 10Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay [AID477845, Type: Literature]
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23
[SID103168531]
EC50 10Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay [AID477846, Type: Literature]
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24
[SID103168531]
EC50 10Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay [AID477847, Type: Literature]
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25
[SID103168531]
EC50 10Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay [AID477848, Type: Literature]
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26
[SID103168531]
EC50 10Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay [AID477849, Type: Literature]
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27
[SID103168531]
EC50 10Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay [AID477850, Type: Literature]
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28
[SID103168531]
EC50 10Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method [AID477851, Type: Literature]
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29
[SID103168531]
IC50 100Inhibitory activity against protein kinase C (PKC) [AID165132, Type: other]
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30
[SID103168531]
IC50 500In vitro inhibitory concentration against PC-3 cell line in MTT assay was determined after 3 days incubation [AID248692, Type: Literature]
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31
[SID103168531]
IC50 500In vitro inhibitory concentration against SKOV3 cell line in MTT assay was determined after 3 days incubation [AID248706, Type: Literature]
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32
[SID103168531]
IC50 500In vitro inhibitory concentration against U373MG cell line in MTT assay was determined after 3 days incubation [AID248718, Type: Literature]
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33
[SID103168531]
IC50 850.3Modulation of classical complement pathway system assessed as hemoglobin release by spectrophotometry [AID380219, Type: Literature]
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34
[SID103168531]
Inhibition of HIV-1 replication in H9 (human lymphoma) cells. [AID78762, Type: other]
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35
[SID103168531]
Inhibition of uninfected H9 lymphocytic cell growth [AID78929, Type: other]
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36
[SID103168531]
Cytotoxicity against human MT4 cells by MTT assay [AID380205, Type: Literature]
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37
[SID103168531]
Selectivity index, ratio of CC50 for human MT4 cells to IC50 for HIV infected in human MT4 cells [AID380206, Type: Literature]
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38
[SID103168531]
Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID380207, Type: Literature]
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39
[SID103168531]
Antimicrobial activity against Candida albicans [AID380212, Type: Literature]
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40
[SID103168531]
Antimicrobial activity against Staphylococcus aureus [AID380213, Type: Literature]
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41
[SID103168531]
Antimicrobial activity against Mycobacterium fortuitum [AID380214, Type: Literature]
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42
[SID103168531]
Antimicrobial activity against Enterobacter cloacae [AID380215, Type: Literature]
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43
[SID103168531]
Antimicrobial activity against Salmonella paratyphi [AID380216, Type: Literature]
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44
[SID103168531]
Antimicrobial activity against Pseudomonas aeruginosa [AID380217, Type: Literature]
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45
[SID103168531]
Antimicrobial activity against Escherichia coli [AID380218, Type: Literature]
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46
[SID103168531]
Compound was tested for O2- scavanging activity using NBT method at a concentration of 20 ug/mL. [AID182177, Type: Literature]
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47
[SID103168531]
Compound was tested for antioxidative activity using TBA method at a concentration of 200 ug/mL. [AID182346, Type: Literature]
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48
[SID103168531]
Therapeutic index - IC50/EC50. [AID235579, Type: other]
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49
[SID103168531]
Therapeutic index was determined [AID235740, Type: other]
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50
[SID103168531]
Antioxidant activity in BALB/c mouse BM cells assessed as inhibition of ROS production [AID293299, Type: Literature]
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