Inositol 1,4,5-Trisphosphate (CID 439456) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(33)
 
 
Top Targets:
RYDR ITPR(8)
 
 
ENTH epsin(1)
 
 
PH PLC delta(1)
 
 
PH beta spect..(1)
 
 
BioAssay Types:
Literature(28)
 
 
BioActivity Types:
Kd(13)
 
 
EC50(12)
 
 
IC50(4)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 31    Data Row: 33   Total Pages: 1   
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OutcomeTypeValue [μM]
1
[SID103181737]
EC50 8e-05Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes with respect to compound 2 [AID175673, Type: Literature]
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2
[SID103181737]
Kd 0.00021Displacement of [3H]IP3 from rat recombinant IP3R1 binding core residue (224-604) expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495146, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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3
[SID103181737]
Kd 0.00027Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) V33K mutant expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495141, Type: Literature]
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4
[SID103181737]
Kd 0.00045Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) K127E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495149, Type: Literature]
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5
[SID103181737]
Kd 0.00046Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) R36E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495148, Type: Literature]
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6
[SID103181737]
Kd 0.00098Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) D34K mutant expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495147, Type: Literature]
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7
[SID103181737]
Kd 0.00232Displacement of [3H]IP3 from rat recombinant N-terminal IP3R1 (1-604) expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495145, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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8
[SID103181737]
Kd 0.00264Displacement of [3H]IP3 from rat recombinant IP3R1 N-terminal residue (1-604) K52E mutant expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495150, Type: Literature]
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9
[SID103181737]
Kd 0.00456Binding affinity towards rat liver membrane, measured using equilibrium competition binding with [3H]Inositol(1,4,5)P3 [AID92903, Type: Literature]
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10
[SID103181737]
Kd 0.01Binding affinity on adrenal cortex microsomes [AID32952, Type: other]
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11
[SID103181737]
IC50 0.01Binding affinity against Ins(1,4,5)P3 receptor prepared from purified rat brain cerebellum [AID143589, Type: other]
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12
[SID103181737]
Kd 0.0125Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assay [AID495143, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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13
[SID103181737]
EC50 0.02Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular stores [AID495142, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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14
[SID103181737]
EC50 0.0223Agonist activity at rat recombinant IP3R1 V33K mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores [AID495151, Type: Literature]
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15
[SID103181737]
EC50 0.023Agonist activity at rat IP3R1 expressed in chicken DT40 cells assessed as induction of Ca2+ release [AID661327, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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16
[SID103181737]
EC50 0.0248Agonistic potency at rat IP3 type 1 receptor expressed in chicken DT40 cells [AID261530, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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17
[SID103181737]
EC50 0.0248Activity at rat IP3 type 1 receptor expressed in DT40 cell assessed as calcium ion mobilization [AID270919, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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18
[SID103181737]
EC50 0.0266Agonist activity at rat recombinant IP3R1 D34K mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores [AID495152, Type: Literature]
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19
[SID103181737]
EC50 0.0408Agonist activity at rat recombinant IP3R1 R36E mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores [AID495153, Type: Literature]
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20
[SID103181737]
Kd 0.054Chemical stability in presence of alkaline phosphatase [AID322908, Type: Literature]
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21
[SID103181737]
EC50 0.085Agonist activity at rat recombinant IP3R1 K52E mutant expressed in chicken DT40 cells assessed as calcium release from intracellular stores [AID495154, Type: Literature]
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22
[SID103181737]
EC50 0.09Concentration causing maximal effect on [Ca2+] release from the intracellular stores of permealized hepatocytes [AID195054, Type: other]
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23
[SID103181737]
EC50 0.185Effective concentration causing half-maximal [Ca2+] release in rat hepatocytes [AID175672, Type: Literature]
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24
[SID103181737]
Kd 0.195Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4 [AID92897, Type: Literature]
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25
[SID103181737]
IC50 0.2Binding affinity against Ins(1,4,5)P3 receptor prepared from purified guinea pig hepatocytes [AID143587, Type: other]
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26
[SID103181737]
Kd 0.26Dissociation constant using IP3-binding domain (IBD) of human Type 1 inositol 1,4,5-trisphosphate receptor [AID215783, Type: Literature]
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27
[SID103181737]
IC50 0.3Binding affinity against Ins(1,4,5)P3 receptor in swiss 3T3 cells [AID143588, Type: other]
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28
[SID103181737]
EC50 0.329Effect on [Ca2+] efflux in rat hepatocytes [AID227792, Type: Literature]
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29
[SID103181737]
IC50 14Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. [AID92774, Type: Literature]
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30
[SID103181737]
 Activity at rat IP3 type 1 receptor expressed in DT40 cell assessed by calcium ion mobilization relative to adenophostin A [AID270921, Type: Literature]Inositol 1,4,5-trisphosphate receptor type 1 [gi:17380349]
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31
[SID46391586]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of The Binding Site For Inositol Phosphates In A Ph Domain [gi:157830462]
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32
[SID46392067]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Epsin Enth Bound To Ins(1,4,5)p3 [gi:24987290]
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33
[SID46392501]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of The Pleckstrin Homology Domain From Phospholipase C Delta In Complex With Inos [gi:157831925]
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