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naringenin (CID 439246) - Compound BioActivity Data
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BioActivity Outcomes:
Active(57)
 
 
Inactive(884)
 
 
Inconclusive(50)
 
 
Unspecified(202)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
p450(21)
 
 
 
 
7TM GPCR Srsx(20)
 
 
NR LBD PPAR(12)
 
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(499)
 
 
 
 
Confirmatory(328)
 
 
 
 
 
Literature(280)
 
 
 
 
 
BioActivity Types:
Potency(233)
 
 
 
 
 
IC50(92)
 
 
 
 
 
EC50(21)
 
 
 
 
Kd(8)
 
 
Ki(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1035    Data Row: 1193   Total Pages: 60   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168452]
IC50 0.0029Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Aromatase [gi:117293]
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2
[SID103168452]
IC50 0.23Inhibition of human aromatase using dibenzylfluorescein as substrate preincubated for 30 mins measured after 2 hrs by fluorimetry [AID642091, Type: Literature]Aromatase [gi:117293]
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3
[SID103168452]
IC50 0.23Inhibition of human aromatase activity after 30 mins by fluorescence analysis [AID719271, Type: Literature]Aromatase [gi:117293]
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4
[SID103168452]
IC50 0.23Inhibition of aromatase after 10 mins preincubation by plate reader relative to control [AID630248, Type: Literature]
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5
[SID103168452]
Kd 0.95499Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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6
[SID103168452]
IC50 1.2Inhibition of aromatase (unknown origin) using dibenzylfluorscein as substrate incubated with NADP+ for 10 mins prior to substrate addition measured after 30 mins by fluorescence assay [AID772978, Type: Literature]Aromatase [gi:117293]
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7
[SID103168452]
I50 1.8Inhibition of rat liver mitochondrial ATPase assessed per mg of protein [AID338025, Type: Literature]
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8
[SID170484818]
Kd 2.29Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Wild Type Ttr Binding Naringenin (Ttrwt:nar) [gi:422919339]
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9
[SID170484818]
Kd 2.29Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of The Wild Type Ttr Binding Naringenin (Ttrwt:nar) [gi:422919339]
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10
[SID170484818]
Kd 2.29Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain B, Crystal Structure Of The Wild Type Ttr Binding Naringenin (Ttrwt:nar) [gi:422919340]
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11
[SID170484818]
Kd 2.29Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain B, Crystal Structure Of The Wild Type Ttr Binding Naringenin (Ttrwt:nar) [gi:422919340]
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12
[SID103168452]
Ki 2.4Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay [AID427748, Type: Literature]
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13
[SID103168452]
IC50 3.3Inhibition of aromatase (unknown origin) using dibenzylfluorescein as substrate after 30 mins by fluorescence assay [AID774132, Type: Literature]Aromatase [gi:117293]
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14
[SID103168452]
IC50 3.656Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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15
[SID103168452]
IC50 4.96Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406995, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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16
[SID11112355]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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17
[SID11113265]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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18
[SID103168452]
IC50 13.473Displacement of [3H]E2 from human recombinant ERbeta LBD by SPA [AID274384, Type: Literature]Estrogen receptor beta [gi:6166154]
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19
[SID103168452]
EC50 13.48Antioxidant activity assessed as ABTS radical scavenging activity [AID528045, Type: Literature]
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20
[SID103168452]
IC50 14.4Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406997, Type: Literature]Estradiol 17-beta-dehydrogenase 2 [gi:544152]
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