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naringenin (CID 439246) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(46)
 
 
Inactive(861)
 
 
Inconclusive(50)
 
 
Unspecified(182)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
7TM GPCR Srsx(20)
 
 
p450(19)
 
 
 
 
Bcl-2 like(12)
 
 
NR LBD PPAR(12)
 
 
 
BioAssay Types:
Screening(498)
 
 
 
 
Confirmatory(327)
 
 
 
 
 
Literature(218)
 
 
 
 
 
BioActivity Types:
Potency(233)
 
 
 
 
 
IC50(84)
 
 
 
 
 
EC50(21)
 
 
 
 
Ki(5)
 
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 993    Data Row: 1139   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168452]
IC50 0.0029Inhibition of human placental microsome CYP19 [AID479369, Type: Literature]Aromatase [gi:117293]
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2
[SID103168452]
IC50 0.23Inhibition of human aromatase using dibenzylfluorescein as substrate preincubated for 30 mins measured after 2 hrs by fluorimetry [AID642091, Type: Literature]Aromatase [gi:117293]
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3
[SID103168452]
IC50 0.23Inhibition of human aromatase activity after 30 mins by fluorescence analysis [AID719271, Type: Literature]Aromatase [gi:117293]
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4
[SID103168452]
IC50 0.23Inhibition of aromatase after 10 mins preincubation by plate reader relative to control [AID630248, Type: Literature]
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5
[SID103168452]
Kd 0.95499Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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6
[SID103168452]
I50 1.8Inhibition of rat liver mitochondrial ATPase assessed per mg of protein [AID338025, Type: Literature]
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7
[SID103168452]
Ki 2.4Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay [AID427748, Type: Literature]
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8
[SID103168452]
IC50 3.656Inhibition of human CYP1B1 by EROD assay [AID502475, Type: Literature]Cytochrome P450 1B1 [gi:48429256]
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9
[SID103168452]
IC50 4.96Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406995, Type: Literature]Estradiol 17-beta-dehydrogenase 1 [gi:313104233]
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10
[SID11112355]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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11
[SID11113265]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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12
[SID103168452]
IC50 13.473Displacement of [3H]E2 from human recombinant ERbeta LBD by SPA [AID274384, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103168452]
EC50 13.48Antioxidant activity assessed as ABTS radical scavenging activity [AID528045, Type: Literature]
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14
[SID103168452]
IC50 14.4Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiol [AID406997, Type: Literature]Estradiol 17-beta-dehydrogenase 2 [gi:544152]
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15
[SID103168452]
IC50 15.167Inhibition of human CYP1A1 by EROD assay [AID502474, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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16
[SID103168452]
IC50 17Inhibition of aromatase from human placental microsomes [AID357965, Type: Literature]Aromatase [gi:117293]
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17
[SID103168452]
IC50 21.48Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrate [AID347259, Type: Literature]Carbonyl reductase [NADPH] 1 [gi:118519]
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18
[SID103168452]
IC50 22.01Inhibition of human recombinant calmodulin assessed as inhibition of calmodulin-sensitive cAMP phosphodiesterase activation after 15 mins by spectrophotometric analysis [AID550024, Type: Literature]Calmodulin [gi:49037474]
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19
[SID103168452]
IC50 26.339Inhibition of human CYP1A2 by EROD assay [AID502473, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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20
[SID103168452]
Kd 28.5Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-Glycoprotein [AID150738, Type: Literature]
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21
[SID103168452]
IC50 28.87Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry [AID639825, Type: Literature]Aldose reductase [gi:113596]
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22
[SID103168452]
Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S assay [AID311281, Type: Literature]Mu-type opioid receptor [gi:2851402]
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23
[SID11112355]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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24
[SID103168452]
Cytotoxicity against human drug-resistant LoVo/DX cells after 72 hrs by SRB assay [AID696745, Type: Literature]
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25
[SID103168452]
Cytotoxicity against human drug-sensitive LoVo cells after 72 hrs by SRB assay [AID696746, Type: Literature]
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26
[SID48421898]
DSSTox (NCTRER) National Center for Toxicological Research Estrogen Receptor Binding Database [AID1204, Type: screening]
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27
[SID22405473]
Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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28
[SID103168452]
Antiproliferative activity against human HL60 cells at 30 uM after 48 hrs by MTS assay [AID381804, Type: Literature]
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29
[SID103168452]
Potentiation of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining [AID402474, Type: Literature]
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30
[SID103168452]
Potentiation of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay [AID402476, Type: Literature]
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31
[SID103168452]
Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469799, Type: Literature]
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32
[SID103168452]
Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol after 96 hrs by alamar blue assay [AID469800, Type: Literature]
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33
[SID103168452]
Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol after 96 hrs by alamar blue assay [AID469801, Type: Literature]
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34
[SID103168452]
Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay [AID469802, Type: Literature]
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35
[SID103168452]
Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay [AID469803, Type: Literature]
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36
[SID103168452]
Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay [AID469804, Type: Literature]
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37
[SID103168452]
Estrogenic activity in luciferase transfected human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay [AID469805, Type: Literature]
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38
[SID103168452]
Estrogenic activity in luciferase transfected human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by luciferase reporter gene assay [AID469806, Type: Literature]
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39
[SID22405473]
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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40
[SID11113265]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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41
[SID11112355]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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42
[SID11112355]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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43
[SID103168452]
Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S assay [AID311280, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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44
[SID103168452]
Inhibition of FabG at 100 uM [AID265765, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
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45
[SID22405473]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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46
[SID103168452]
Antagonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTPgammaS assay [AID311282, Type: Literature]Delta-type opioid receptor [gi:311033488]
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47
[SID103168452]
EC50 1Cytotoxicity against human Col2 cells [AID399940, Type: Literature]
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48
[SID103168452]
ED50 1Cytotoxicity against HUVEC [AID399941, Type: Literature]
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49
[SID103168452]
ED50 1Cytotoxicity against human KB cells [AID399942, Type: Literature]
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50
[SID103168452]
ED50 1Cytotoxicity against human LNCAP cells [AID399943, Type: Literature]
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