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Bradykinin (CID 439201) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(30)
 
 
Unspecified(32)
 
 
Top Targets:
Bromo ALL-1(2)
 
 
Menin(2)
 
 
NR LBD TR(2)
 
 
RIP(2)
 
 
HELICc(2)
 
 
BioAssay Types:
Literature(40)
 
 
 
Confirmatory(25)
 
 
Screening(5)
 
 
BioActivity Types:
Potency(25)
 
 
Ki(5)
 
 
 
IC50(4)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 67    Data Row: 71   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103279772]
IC50 1e-05Inhibitory activity against high affinity binding site of Bradykinin receptor in guinea pig ileum was reported. [AID42977, Type: Literature]
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2
[SID103279772]
IC50 1e-05Inhibitory activity against high affinity binding site of Bradykinin receptor in rat uterus membrane was reported. [AID42985, Type: Literature]
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3
[SID103279772]
EC50 4.9e-05Antagonist activity at human recombinant bradykinin 2 receptor expressed in CHO cells assessed as inhibition of bradykinin-induced intracellular calcium mobilization [AID375520, Type: Literature]B2 bradykinin receptor [gi:2506481]
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4
[SID103279772]
Ki 6.5e-05Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement. [AID43290, Type: Literature]
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5
[SID103279772]
Ki 0.00011Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin [AID43292, Type: Literature]B2 bradykinin receptor [gi:2506481]
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6
[SID103279772]
Ki 0.00046Binding affinity against rat Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand [AID43305, Type: Literature]
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7
[SID103279772]
Ki 0.00065Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand [AID43286, Type: Literature]
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8
[SID103279772]
IC50 0.001Inhibitory activity against low affinity binding site site of Bradykinin receptor in rat uterus membrane was reported. [AID42988, Type: Literature]
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9
[SID103279772]
IC50 0.00175Inhibitory activity against low affinity binding site of Bradykinin receptor in guinea pig ileum [AID42978, Type: Literature]
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10
[SID103279772]
Ki 0.01Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin. [AID42993, Type: Literature]B1 bradykinin receptor [gi:85681914]
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11
[SID103279772]
Antagonist activity at human recombinant bradykinin 2 receptor expressed in CHO cells assessed as inhibition of bradykinin-induced intracellular calcium mobilization at up to 10 uM [AID375527, Type: Literature]B2 bradykinin receptor [gi:2506481]
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12
[SID103279772]
Binding affinity towards bradykinin receptor using [3H]BK as radioligand in guinea pig ileum [AID42982, Type: Literature]
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13
[SID103279772]
Binding affinity towards Bradykinin receptor B2 in human S34 clone cells [AID43145, Type: Literature]
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14
[SID103279772]
Compound was evaluated for renal vasodilator activity and represented as ED15 (intravenous administration) [AID59130, Type: Literature]
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15
[SID103279772]
Agonistic activity against selectivity for smooth muscle contraction in guinea pig ileum. [AID73863, Type: Literature]
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16
[SID103279772]
Antagonistic activity was evaluated in Guinea pig ileum assay. [AID73988, Type: Literature]
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17
[SID103279772]
Antagonistic activity was evaluated in Guinea pig lung strip assay. [AID73989, Type: Literature]
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18
[SID103279772]
Compound was evaluated for muscle stimulating potency in isolated guinea pig ilea [AID76465, Type: Literature]
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19
[SID103279772]
Compound was tested for antagonist activity for contraction of guinea pig ileum; the negative logarithm of ED50 (pD2) was estimated. [AID79670, Type: Literature]
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20
[SID103279772]
Ability of Compound (Agonist) to contract isolated human umbilical vein in presence of inhibitor. [AID89831, Type: Literature]
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21
[SID103279772]
Ability to inhibit contraction of human umbilical vein (HUV) induced by [des-Arg10]-Kallidin; Not determined [AID92418, Type: other]
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22
[SID103279772]
Inhibition of contraction of human umbilical vein (HUV) induced by different concentrations of bradykinin was determined [AID92423, Type: Literature]
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23
[SID103279772]
Ability of Compound (Agonist) to contract isolated human umbilical vein in absence of inhibitor. [AID92586, Type: Literature]
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24
[SID103279772]
Agonistic activity on human umbilical vein(HUV) in absence of inhibitors [AID92588, Type: Literature]
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25
[SID103279772]
Agonistic activity on human umbilical vein(HUV) in presence of inhibitors [AID92692, Type: Literature]
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26
[SID103279772]
ChEMBL 89883 [AID92693, Type: Literature]
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27
[SID103279772]
Agonistic activity against selectivity for smooth muscle contraction in rat uterus. [AID168238, Type: Literature]
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28
[SID103279772]
Agonistic activity was evaluated in Estrus Rat Uterus Assay [AID168242, Type: Literature]
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29
[SID103279772]
% Change in renal vascular resistance in rats when administered at dose 15 ug/kg intravenously [AID171718, Type: Literature]
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30
[SID103279772]
% Change in renal vascular resistance in rats when administered at dose 3 ug/kg intravenously [AID171719, Type: Literature]
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31
[SID103279772]
Agonistic activity on rat uterus(RUT) in absence of inhibitors [AID197172, Type: Literature]
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32
[SID103279772]
Agonistic activity on rat uterus(RUT) in presence of inhibitors [AID197173, Type: Literature]
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33
[SID103279772]
Compound was tested for antagonist activity for contraction of rat uterus , the negative logarithm of ED50 (pD2) was estimated. [AID197180, Type: Literature]
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34
[SID103279772]
Selectivity for rat uterus is expressed as the ratio RUT/GPI [AID232231, Type: Literature]
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35
[SID103279772]
Ratio of ED20 of MABP (mean arterial blood pressure) to the ED15 of RVR ( renal vascular resistance). [AID232387, Type: Literature]
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36
[SID103279772]
Ratio of ED30 of iliac vascular resistant (IVR) to the ED15 of RVR(renal vascular resistance) [AID232390, Type: Literature]
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37
[SID103279772]
Average max percent decrease in RVR (renal vascular resistance) was determined. [AID16165, Type: Literature]
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38
[SID103279772]
In vitro stability was measured in human plasma tissue preparation [AID24166, Type: Literature]
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39
[SID103279772]
In vitro stability was measured in porcine kidney tissue preparation [AID24342, Type: Literature]
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40
[SID103279772]
In vitro stability was measured in porcine lung tissue preparation [AID24343, Type: Literature]
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41
[SID103279772]
In vitro stability was measured in rat kidney tissue preparation [AID24344, Type: Literature]
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42
[SID50112435]
Potency 35.4813qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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43
[SID50112435]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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44
[SID50112435]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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45
[SID50112435]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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46
[SID50112435]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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47
[SID50112435]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID50112435]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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49
[SID50112435]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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50
[SID50112435]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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