Bookmark and Share
Bradykinin (CID 439201) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(11)
 
 
Inactive(30)
 
 
Unspecified(37)
 
 
Top Targets:
Bromo ALL-1(2)
 
 
Menin(2)
 
 
NR LBD TR(2)
 
 
RIP(2)
 
 
HELICc(2)
 
 
BioAssay Types:
Literature(48)
 
 
 
Confirmatory(25)
 
 
Screening(5)
 
 
BioActivity Types:
Potency(25)
 
 
Ki(5)
 
 
 
IC50(5)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 74    Data Row: 78   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103279772]
IC50 1e-05Inhibitory activity against high affinity binding site of Bradykinin receptor in guinea pig ileum was reported. [AID42977, Type: Literature]
View
2
[SID103279772]
IC50 1e-05Inhibitory activity against high affinity binding site of Bradykinin receptor in rat uterus membrane was reported. [AID42985, Type: Literature]
View
3
[SID103279772]
EC50 4.9e-05Antagonist activity at human recombinant bradykinin 2 receptor expressed in CHO cells assessed as inhibition of bradykinin-induced intracellular calcium mobilization [AID375520, Type: Literature]B2 bradykinin receptor [gi:2506481]
View
4
[SID103279772]
Ki 6.5e-05Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement. [AID43290, Type: Literature]
View
5
[SID103279772]
Ki 0.00011Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykinin [AID43292, Type: Literature]B2 bradykinin receptor [gi:2506481]
View
6
[SID103279772]
Ki 0.00046Binding affinity against rat Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand [AID43305, Type: Literature]
View
7
[SID103279772]
Ki 0.00065Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand [AID43286, Type: Literature]
View
8
[SID103279772]
IC50 0.001Inhibitory activity against low affinity binding site of Bradykinin receptor in rat uterus membrane was reported. [AID42988, Type: Literature]
View
9
[SID103279772]
ED50 0.00165In vitro 50 % Maximal response in jugular vein expressing B2 receptor [AID167729, Type: Literature]
View
10
[SID103279772]
IC50 0.00175Inhibitory activity against low affinity binding site of Bradykinin receptor in guinea pig ileum [AID42978, Type: Literature]
View
11
[SID103279772]
IC50 0.0018Displacement of [3H]Bradykinin from human recombinant bradykinin B2 receptor expressed in CHEM1 cells after 60 mins [AID751692, Type: Literature]B2 bradykinin receptor [gi:2506481]
View
12
[SID103279772]
Ki 0.01Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin. [AID42993, Type: Literature]B1 bradykinin receptor [gi:85681914]
View
13
[SID103279772]
Displacement of [3H]Bradykinin from human recombinant bradykinin B2 receptor expressed in CHEM1 cells at 10 uM after 60 mins relative to control [AID751757, Type: Literature]B2 bradykinin receptor [gi:2506481]
View
14
[SID103279772]
Antagonist activity at human recombinant bradykinin 2 receptor expressed in CHO cells assessed as inhibition of bradykinin-induced intracellular calcium mobilization at up to 10 uM [AID375527, Type: Literature]B2 bradykinin receptor [gi:2506481]
View
15
[SID103279772]
Binding affinity towards bradykinin receptor using [3H]BK as radioligand in guinea pig ileum [AID42982, Type: Literature]
View
16
[SID103279772]
Binding affinity towards Bradykinin receptor B2 in human S34 clone cells [AID43145, Type: Literature]
View
17
[SID103279772]
Average max percent decrease in RVR (renal vascular resistance) was determined. [AID16165, Type: Literature]
View
18
[SID103279772]
In vitro stability was measured in human plasma tissue preparation [AID24166, Type: Literature]
View
19
[SID103279772]
In vitro stability was measured in porcine kidney tissue preparation [AID24342, Type: Literature]
View
20
[SID103279772]
In vitro stability was measured in porcine lung tissue preparation [AID24343, Type: Literature]
View