Bookmark and Share
Paroxetine (CID 43815) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(95)
 
 
Inactive(134)
 
 
Inconclusive(76)
 
 
Unspecified(412)
 
 
Top Targets:
7tm 4(38)
 
 
 
 
 
p450(19)
 
 
 
 
SLC6sbd SERT(16)
 
 
 
NR LBD ER(9)
 
 
 
 
MFS(9)
 
 
 
 
BioAssay Types:
Confirmatory(287)
 
 
 
 
 
Literature(198)
 
 
 
 
 
Summary(24)
 
 
 
Screening(16)
 
 
BioActivity Types:
Potency(182)
 
 
 
 
IC50(154)
 
 
 
 
 
Ki(28)
 
 
 
Kd(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 692    Data Row: 717   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234151]
Ki 4e-05Binding inhibition towards human serotonin transporter [AID254322, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
2
[SID104234151]
Ki 7.7e-05Evaluated for affinity at 5-HT uptake site using [3H]paroxetine as radioligand in radioligand binding assay [AID205020, Type: confirmatory]
View
3
[SID104234151]
IC50 8e-05DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
View
4
[SID104234151]
Ki 9e-05Displacement of [3H]paroxetine from SERT receptor in human platelet membrane [AID302140, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
5
[SID104234151]
Kd 0.00013Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERT [AID204080, Type: Literature]
View
6
[SID104234151]
Kd 0.00015The potency of the [3H]paroxetine for 5-HT transporters [AID204516, Type: Literature]
View
7
[SID104234151]
IC50 0.0002Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells after 1 hr by scintillation counting analysis [AID739022, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
8
[SID104234151]
IC50 0.00028Inhibition of [3H]paroxetine (0.2 nM) binding to 5-HT transporter [AID205038, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
View
9
[SID104234151]
Ki 0.00031Displacement of [3H]-paroxetine from SERT in rabbit cortical membrane [AID587249, Type: Literature]
View
10
[SID104234151]
Ki 0.00038Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID361596, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
11
[SID104234151]
Ki 0.00038Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
12
[SID104234151]
Ki 0.00042Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
13
[SID104234151]
Ki 0.00042Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID361595, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
14
[SID104234151]
Ki 0.00044Tested in vitro for serotonin(5-HT) neuronal uptake inhibition [AID134217, Type: Literature]
View
15
[SID104234151]
Ki 0.00053Displacement of [3H]citalopram from rat cortical serotonin transporter (SERT) [AID204695, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
View
16
[SID104234151]
Ki 0.00053Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex [AID204703, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
View
17
[SID104234151]
Ki 0.0007Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar rats [AID204534, Type: Literature]
View
18
[SID104234151]
Ki 0.00073Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomes [AID186981, Type: Literature]
View
19
[SID104234151]
IC50 0.002Inhibition of serotonin uptake at human SERT expressed in JAR cells [AID387488, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
View
20
[SID104234151]
IC50 0.00643Inhibition of uptake of [3H]5-HT in synaptosomes from rat cortex [AID196387, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
View