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AC1NA0PL (CID 4369759) - Compound BioActivity Data
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BioActivity Outcomes:
Active(51)
 
 
Inactive(638)
 
 
Inconclusive(20)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srsx(22)
 
 
 
7TM GPCR Srx(22)
 
 
 
Bcl-2 like(11)
 
 
RGS RGS4(9)
 
 
 
 
ABCC CFTR1(8)
 
 
 
 
BioAssay Types:
Screening(471)
 
 
 
 
 
Confirmatory(219)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(153)
 
 
 
 
 
IC50(52)
 
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 641    Data Row: 715   Total Pages: 36   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22405172]
IC50_Mean 1.07Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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2
[SID22405172]
IC50_Mean 1.5Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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3
[SID22405172]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID22405172]
Potency 8.9125qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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5
[SID22405172]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID22405172]
Potency 10VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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7
[SID22405172]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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8
[SID22405172]
Potency 10qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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9
[SID22405172]
Potency 10qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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10
[SID22405172]
Potency 10.3225qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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11
[SID22405172]
Potency 12.5893qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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12
[SID22405172]
Potency 12.9953qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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13
[SID22405172]
Potency 12.9953qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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14
[SID22405172]
Potency 17.7828qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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15
[SID22405172]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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16
[SID22405172]
Potency 25.1189qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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17
[SID22405172]
Potency 28.1838qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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18
[SID99494288]
IC50 34Biochemical assay for compounds that inhibit RGS4 stimulation of Galpha1 nucleotide hydrolysis under receptor-independent steady-state conditions [AID588552, Type: confirmatory]regulator of G-protein signaling 4 [Rattus norvegicus] [gi:8394183]
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19
[SID99494288]
IC50 34Biochemical assay for compounds that inhibit RGS4 stimulation of Galpha1 nucleotide hydrolysis under receptor-independent steady-state conditions [AID588552, Type: confirmatory] [geneid:29480]
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20
[SID22405172]
Potency 79.4328Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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