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Digitoxigenin (CID 4369270) - Compound BioActivity Data
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BioActivity Outcomes:
Active(176)
 
 
Inactive(436)
 
 
Inconclusive(20)
 
 
Unspecified(34)
 
 
Top Targets:
7tm 4(35)
 
 
 
CAP ED(5)
 
 
Esterase lipa..(5)
 
 
Bcl-2 like(5)
 
 
 
Alpha TIF(5)
 
 
BioAssay Types:
Screening(351)
 
 
 
 
Confirmatory(202)
 
 
 
 
 
Literature(93)
 
 
 
 
 
BioActivity Types:
Potency(105)
 
 
 
 
 
IC50(49)
 
 
 
 
 
AC50(7)
 
 
 
 
EC50(6)
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 620    Data Row: 666   Total Pages: 34   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46392445]
Kd 0.002Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Anticalin Diga16 In Complex With Digitoxigenin [gi:33357297]
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2
[SID46392445]
Kd 0.002Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Anticalin Diga16 In Complex With Digitoxigenin [gi:33357297]
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3
[SID103521343]
IC50 0.008Inhibition of [3H]- ouabain binding to digitalis receptor [AID56911, Type: Literature]
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4
[SID103521343]
IC50 0.02Inhibition of [3H]ouabain binding to Na/K ATP-ase in dog heart muscle [AID49025, Type: Literature]
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5
[SID56463036]
IC50 0.05A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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6
[SID103521343]
EC50 0.057In vitro increase in contractile force of the guine pig atrium. [AID73714, Type: Literature]
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7
[SID103521343]
IC50 0.063Binding affinity towards Na+,K+ -ATPase isolated from dog kidney. [AID146843, Type: Literature]
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8
[SID103521343]
IC50 0.06350% displacement of the specific [3H]ouabain binding from the dog kidney Na+/K+ ATPase [AID146853, Type: Literature]
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9
[SID103521343]
IC50 0.0631Displacement of [3H]ouabain binding from Na+,K+ -ATPase receptor isolated from dog kidney [AID146839, Type: confirmatory]
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10
[SID103521343]
IC50 0.0765Cytotoxicity against human TK10 cells after 48 hrs by SRB assay [AID399010, Type: Literature]
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11
[SID103521343]
IC50 0.08Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPase [AID146857, Type: Literature]
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12
[SID103521343]
IC50 0.117Inhibitory activity against Hog kidney Na+, K+ -Dependent ATPase [AID146842, Type: Literature]
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13
[SID103521343]
IC50 0.12Inhibition of hog kidney Na+, K+-dependent ATPase [AID146845, Type: Literature]
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14
[SID103521343]
IC50 0.15Cytotoxicity against human Hs578Bst cells after 72 hrs by CellTiter-Glo assay [AID657872, Type: Literature]
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15
[SID56463036]
IC50_Mean 0.16Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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16
[SID103521343]
IC50 0.1944Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID399011, Type: Literature]
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17
[SID56463036]
Potency 0.206Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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18
[SID56463036]
AC50_uM 0.2339Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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19
[SID56463036]
Potency 0.2593qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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20
[SID56463036]
Potency 0.2593Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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