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Digitoxigenin (CID 4369270) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(174)
 
 
Inactive(429)
 
 
Inconclusive(20)
 
 
Unspecified(34)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
7TM GPCR Srsx(15)
 
 
 
Alpha TIF(5)
 
 
Bcl-2 like(5)
 
 
 
B zip1(5)
 
 
 
BioAssay Types:
Screening(350)
 
 
 
 
Confirmatory(201)
 
 
 
 
 
Literature(81)
 
 
 
 
 
BioActivity Types:
Potency(105)
 
 
 
 
 
IC50(49)
 
 
 
 
 
AC50(7)
 
 
 
 
EC50(6)
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 618    Data Row: 657   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103521343]
IC50 0.008Inhibition of [3H]- ouabain binding to digitalis receptor [AID56911, Type: Literature]
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2
[SID103521343]
IC50 0.02Inhibition of [3H]ouabain binding to Na/K ATP-ase in dog heart muscle [AID49025, Type: Literature]
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3
[SID56463036]
IC50 0.05A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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4
[SID103521343]
EC50 0.057In vitro increase in contractile force of the guine pig atrium. [AID73714, Type: Literature]
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5
[SID103521343]
IC50 0.063Binding affinity towards Na+,K+ -ATPase isolated from dog kidney. [AID146843, Type: Literature]
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6
[SID103521343]
IC50 0.06350% displacement of the specific [3H]ouabain binding from the dog kidney Na+/K+ ATPase [AID146853, Type: Literature]
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7
[SID103521343]
IC50 0.0631Displacement of [3H]ouabain binding from Na+,K+ -ATPase receptor isolated from dog kidney [AID146839, Type: other]
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8
[SID103521343]
IC50 0.0765Cytotoxicity against human TK10 cells after 48 hrs by SRB assay [AID399010, Type: Literature]
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9
[SID103521343]
IC50 0.08Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPase [AID146857, Type: Literature]
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10
[SID103521343]
IC50 0.117Inhibitory activity against Hog kidney Na+, K+ -Dependent ATPase [AID146842, Type: Literature]
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11
[SID103521343]
IC50 0.12Inhibition of hog kidney Na+, K+-dependent ATPase [AID146845, Type: Literature]
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12
[SID103521343]
IC50 0.15Cytotoxicity against human Hs578Bst cells after 72 hrs by CellTiter-Glo assay [AID657872, Type: Literature]
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13
[SID56463036]
IC50_Mean 0.16Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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14
[SID103521343]
IC50 0.1944Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID399011, Type: Literature]
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15
[SID56463036]
Potency 0.206Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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16
[SID56463036]
AC50_uM 0.2339Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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17
[SID56463036]
Potency 0.2593qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID56463036]
Potency 0.2593Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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19
[SID103521343]
IC50 0.3488Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay [AID399012, Type: Literature]
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20
[SID56463036]
AbsAC35_uM 0.395Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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21
[SID56463036]
AC50_uM 0.4673Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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22
[SID103521343]
IC50 0.5Inhibitory activity against Na+/K+ ATPase was determined [AID146861, Type: Literature]
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23
[SID103521343]
IC50 0.5In vitro inhibitory concentration against dog kidney Na+,K+-ATPase [AID146844, Type: Literature]Sodium/potassium-transporting ATPase subunit alpha-1 [gi:1703466]
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24
[SID103521343]
IC50 0.5Inhibition of Na+/K+ ATPase from dog kidney [AID146848, Type: Literature]Sodium/potassium-transporting ATPase subunit alpha-1 [gi:1703466]
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25
[SID56463036]
Potency 0.5012qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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26
[SID56463036]
Potency 0.5174qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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27
[SID103521343]
EC50 0.57Concentration of compound producing 50% of the maximal increase in force of contraction in electrically driven guinea pig left atrium [AID222114, Type: Literature]
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28
[SID103521343]
EC50 0.57Concentration producing 50% of the maximal increase in the force of contraction in isolated guinea pig left atrium [AID79700, Type: Literature]
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29
[SID103521343]
EC50 0.6In vitro inotropic activity was determined by the affects of contractile force on guinea pig left atrium. [AID79701, Type: Literature]
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30
[SID103521343]
IC50 0.6Antiproliferative activity against human MCF7 cells assessed as cell viability treated for 48 hrs followed by compound washout measured after 72 hrs by fluorometric CellTiter-Blue reagent assay [AID593490, Type: Literature]
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31
[SID56463036]
AbsAC35_uM 0.62Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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32
[SID103521343]
IC50 0.62Inhibition of induction of ICAM1 expression in human A549 cells in presence of IL1-alpha after 1 hr [AID292166, Type: Literature]
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33
[SID56463036]
AbsAC35_uM 0.629HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
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34
[SID56463036]
IC50_Mean 0.67Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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35
[SID103521343]
Ki 0.88Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digitoxin as radioligand [AID127355, Type: Literature]
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36
[SID103521343]
Ki 1Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digoxin as radioligand [AID127356, Type: Literature]
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37
[SID103521343]
IC50 1.022Cytotoxicity against human Hs578T cells after 72 hrs by CellTiter-Glo assay [AID657871, Type: Literature]
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38
[SID56463036]
Potency 1.122qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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39
[SID56463036]
AC50_uM 1.38HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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40
[SID56463036]
CC50 1.45Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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41
[SID103521343]
IC50 1.5Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay [AID356599, Type: Literature]
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42
[SID56463036]
Potency 1.9953qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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43
[SID103521343]
IC50 2.53Cytotoxicity against human T47D cells after 72 hrs by CellTiter-Glo assay [AID657869, Type: Literature]
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44
[SID56463036]
AbsAC35_uM 2.6HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720589, Type: confirmatory]
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45
[SID56463036]
IC50_Mean 3.53Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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46
[SID103521343]
IC50 4.42Cytotoxicity against human SK-BR-3 cells after 72 hrs by CellTiter-Glo assay [AID657870, Type: Literature]
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47
[SID56463036]
AbsAC40_uM 5.74Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_Dose_CherryPick_Activity [AID652053, Type: confirmatory]
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48
[SID103521343]
IC50 8.95Cytotoxicity against human BC cells by SRB assay [AID378432, Type: Literature]
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49
[SID103521343]
IC50 9.1Cytotoxicity against human MCF7 cells after 72 hrs by CellTiter-Glo assay [AID657868, Type: Literature]
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50
[SID103521343]
IC50 9.61Cytotoxicity against human KB cells by SRB assay [AID378431, Type: Literature]
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