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MLS002701836 (CID 434381) - Compound BioActivity Data
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BioActivity Outcomes:
Active(124)
 
 
Inactive(275)
 
 
Inconclusive(14)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(11)
 
 
Alpha TIF(6)
 
 
 
ABCC CFTR1(4)
 
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(228)
 
 
 
 
Confirmatory(173)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(74)
 
 
 
 
 
AC50(13)
 
 
 
 
IC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 383    Data Row: 414   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92763860]
Potency 0.2909qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID92763860]
AC50_uM 0.325HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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3
[SID92763860]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID92763860]
AbsAC35_uM 0.429Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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5
[SID92763860]
Potency 0.5623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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6
[SID92763860]
AC50_uM 0.738CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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7
[SID92763860]
AbsAC35_uM 0.837Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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8
[SID92763860]
Potency 1qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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9
[SID92763860]
Potency 1qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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10
[SID92763860]
Potency 1.1582qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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11
[SID92763860]
Potency 2.0596Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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12
[SID92763860]
AC50_uM 2.22Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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13
[SID92763860]
AC50_uM 2.38HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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14
[SID92763860]
AC50_uM 3.78Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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15
[SID92763860]
AC50_uM 3.82Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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16
[SID92763860]
Max_Activity_Conc_uM 26Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_CherryPick_Activity [AID720570, Type: confirmatory]
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17
[SID92763860]
AC50_uM 53.86Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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18
[SID92763860]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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19
[SID575919]
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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20
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line [AID1, Type: confirmatory]
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21
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line [AID3, Type: confirmatory]
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22
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line [AID5, Type: confirmatory]
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23
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
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24
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line [AID9, Type: confirmatory]
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25
[SID92763860]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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26
[SID92763860]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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27
[SID92763860]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
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28
[SID92763860]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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29
[SID92763860]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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30
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line [AID13, Type: confirmatory]
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31
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line [AID15, Type: confirmatory]
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32
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the LXFL 529 Non-Small Cell Lung cell line [AID17, Type: confirmatory]
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33
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line [AID19, Type: confirmatory]
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34
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line [AID21, Type: confirmatory]
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35
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line [AID23, Type: confirmatory]
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36
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line [AID25, Type: confirmatory]
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37
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the M19-MEL Melanoma cell line [AID27, Type: confirmatory]
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38
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line [AID29, Type: confirmatory]
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39
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line [AID31, Type: confirmatory]
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40
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line [AID33, Type: confirmatory]
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41
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line [AID35, Type: confirmatory]
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42
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line [AID37, Type: confirmatory]
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43
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line [AID39, Type: confirmatory]
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44
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line [AID41, Type: confirmatory]
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45
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line [AID43, Type: confirmatory]
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46
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line [AID45, Type: confirmatory]
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47
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line [AID47, Type: confirmatory]
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48
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line [AID49, Type: confirmatory]
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49
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the XF 498 Central Nervous System cell line [AID51, Type: confirmatory]
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50
[SID575919]
NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line [AID53, Type: confirmatory]
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